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Flashcards in Neoplasia Deck (33):
1

Aflatoxin carcinogen associated with

Hepatocellular carcinoma

2

Alcohol carcinogen associated with

  1. Squamous cell Carcinoma of Oropharynx and upper esophagus
  2. Pancreatic carcinoma
  3. Hepatocellular CA

3

Alkylating agents carcinogen associated with

Leukemia/Lymphoma

4

Arsenic carcinogen associated with

  1. Squamous cell carcinoma of skin
  2. Lung Ca
  3. Angiosarcoma of liver

5

Burkitt translocation

t(8;14)

c-MYC

6

c-MYC translocation [t(8;14)] leads to

Burkitt lymphoma

7

Carcinomas spread via

Lymphatics

8

Chromogranin is marker for

Neuroendocrine cells

9

CML translocation

t(9;22)

TK-ABL

10

Cyclin D1 translocaiton [t(11;14)] leads to

Mantell cell lymphoma

11

Desmin marker for

Muscle

12

EBV carcinogen associated with

Nasopharyngeal Ca

Burkitt lymphoma

CNS lymphoma in AIDs

13

ER marker for 

Breast epithelium

14

ERBB2[HER2/neu] amplification leads to

Subset of breast cancer

15

GFAP marker for

Neuroglia

16

HTLV-1 carcinogen associated with

Adult T-cell leukemia/lymphoma

17

Keratin is marker for

Epithelium

18

KIT point mutation leads to

Gastrointestinal stromal tumor

19

L-MYC amplification leads to

Small cell lung carcinoma

20

Mantle cell lymphoma translocation

t(11;14)

Cyclin D1

21

N-MYC amplification leads to

Neuroblastoma

22

Naphthylamine carcinogen associated with

Urethelial Carcinoma of bladder

23

Nitrosamines carcinogens associated with

Stomach Ca

24

Nitrosamines found in

Smoked foods

25

PDGFB overexpression leads to

Astrocytoma

26

RAS point mutation leads to

Carcinomas

Melanoma

Lymphoma

27

RET point mutation leads to

  1. MEN 2A
  2. MEN 2B
  3. Sporadic medullary carcinoma of thyroid

28

Carcinoma exceptions to hematogenous spread

RCC

Hepatocellular carcinoma

Follicular carcinoma

Choriocarcinoma

29

Sarcomas spread via

Hematogenous

30

Tyrosine kinase ABL translocation [t(9;22)] leads to

CML

31

Vimentin is marker for

Mesenchyme

32

Vinyl chloride carcinogen associated with

Angiosarcoma of liver

33

What is normal Kappa to Lambda light chain ratio

3:1