Neoplasia

Question 1

Aflatoxin carcinogen associated with

Answer 1

Hepatocellular carcinoma

Question 2

Alcohol carcinogen associated with

Answer 2

1. Squamous cell Carcinoma of Oropharynx and upper esophagus
2. Pancreatic carcinoma
3. Hepatocellular CA

Question 3

Alkylating agents carcinogen associated with

Answer 3

Leukemia/Lymphoma

Question 4

Arsenic carcinogen associated with

Answer 4

1. Squamous cell carcinoma of skin
2. Lung Ca
3. Angiosarcoma of liver

Question 5

Burkitt translocation

Answer 5

t(8;14)

c-MYC

Question 6

c-MYC translocation [t(8;14)] leads to

Answer 6

Burkitt lymphoma

Question 7

Carcinomas spread via

Answer 7

Lymphatics

Question 8

Chromogranin is marker for

Answer 8

Neuroendocrine cells

Question 9

CML translocation

Answer 9

t(9;22)

TK-ABL

Question 10

Cyclin D1 translocaiton [t(11;14)] leads to

Answer 10

Mantell cell lymphoma

Question 11

Desmin marker for

Answer 11

Muscle

Question 12

EBV carcinogen associated with

Answer 12

Nasopharyngeal Ca

Burkitt lymphoma

CNS lymphoma in AIDs

Question 13

ER marker for

Answer 13

Breast epithelium

Question 14

ERBB2[HER2/neu] amplification leads to

Answer 14

Subset of breast cancer

Question 15

GFAP marker for

Answer 15

Neuroglia

Question 16

HTLV-1 carcinogen associated with

Answer 16

Adult T-cell leukemia/lymphoma

Question 17

Keratin is marker for

Answer 17

Epithelium

Question 18

KIT point mutation leads to

Answer 18

Gastrointestinal stromal tumor

Question 19

L-MYC amplification leads to

Answer 19

Small cell lung carcinoma

Question 20

Mantle cell lymphoma translocation

Answer 20

t(11;14)

Cyclin D1

Question 21

N-MYC amplification leads to

Answer 21

Neuroblastoma

Question 22

Naphthylamine carcinogen associated with

Answer 22

Urethelial Carcinoma of bladder

Question 23

Nitrosamines carcinogens associated with

Answer 23

Stomach Ca

Question 24

Nitrosamines found in

Answer 24

Smoked foods

Question 25

PDGFB overexpression leads to

Answer 25

Astrocytoma

Question 26

RAS point mutation leads to

Answer 26

Carcinomas Melanoma Lymphoma

Question 27

RET point mutation leads to

Answer 27

1. MEN 2A 2. MEN 2B 3. Sporadic medullary carcinoma of thyroid

Question 28

Carcinoma exceptions to hematogenous spread

Answer 28

RCC Hepatocellular carcinoma Follicular carcinoma Choriocarcinoma

Question 29

Sarcomas spread via

Answer 29

Hematogenous

Question 30

Tyrosine kinase ABL translocation [**t(9;22)**] leads to

Answer 30

CML

Question 31

Vimentin is marker for

Answer 31

Mesenchyme

Question 32

Vinyl chloride carcinogen associated with

Answer 32

Angiosarcoma of liver

Question 33

What is normal Kappa to Lambda light chain ratio

Answer 33

3:1