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Flashcards in Intrinsic AKI Deck (15):
1

Definition of AKI

Abrupt reduction in kidney fxn: Increase in serum creatinie of >=.3mg/dl or >=50% or documented oliguria

2

what is the obligatory solute load?

.5 L/day.

3

define oliguria. anuria

oliguria<.1L/d

4

what state must you be in to calculate GFR

steady state

5

When is a FE Urea better tahn FENa?

when on diuretics

6

What are the three main types of intrinsic ARF?

Tubular, Glomerular, interstitial

7

What are the two principle causes of tubular IRF?

ischemic, toxic

8

What is the most common cause of ischemic ATN? What would the urnine lytes show? Urinalysis?

prerenal azotemia. Na>40, FENa>1%, Urine osms ~300. dark, granular casts

9

Normotensive ischemic AKI

someone with impaired autoregulation has chronic high BP so with regular BP they are underperfused

10

how does filtration fraction change with afferent artery dilation? what causes it? afferent constriction? cause?

prostaglandins, doesn't change much b/c it inreases GFR as well as RPF. No change, equal decrease in GFR and RPF. NSAIDS (decrease PGs)

11

How does Efferent art. dilation change FF? causes? Constriction? causes?

ACE-I, ARB. decreased FF....AT2, increases GFR

12

what are the main causes of toxic ATN? Definition? Mechanism?

Radiocontrast nephropathy. increase in cr > .5mg or 25%. Directly toxic and induces vasospasm (ischemia). Pigment Nephropathy=muscle (myoglobin) or hemolysis (hemoglobin) toxicity

13

Acute interstitial nephritis

result of medication. associated w/ fever, rash, eosinophilia plus hematuria

14

What gives you a pigmented granular cast?

ATN

15

Rhabdomyolysis

Muscle damage causes myoglobin release and toxic ATN