Flashcards in Intrinsic AKI Deck (15):
Definition of AKI
Abrupt reduction in kidney fxn: Increase in serum creatinie of >=.3mg/dl or >=50% or documented oliguria
what is the obligatory solute load?
define oliguria. anuria
what state must you be in to calculate GFR
When is a FE Urea better tahn FENa?
when on diuretics
What are the three main types of intrinsic ARF?
Tubular, Glomerular, interstitial
What are the two principle causes of tubular IRF?
What is the most common cause of ischemic ATN? What would the urnine lytes show? Urinalysis?
prerenal azotemia. Na>40, FENa>1%, Urine osms ~300. dark, granular casts
Normotensive ischemic AKI
someone with impaired autoregulation has chronic high BP so with regular BP they are underperfused
how does filtration fraction change with afferent artery dilation? what causes it? afferent constriction? cause?
prostaglandins, doesn't change much b/c it inreases GFR as well as RPF. No change, equal decrease in GFR and RPF. NSAIDS (decrease PGs)
How does Efferent art. dilation change FF? causes? Constriction? causes?
ACE-I, ARB. decreased FF....AT2, increases GFR
what are the main causes of toxic ATN? Definition? Mechanism?
Radiocontrast nephropathy. increase in cr > .5mg or 25%. Directly toxic and induces vasospasm (ischemia). Pigment Nephropathy=muscle (myoglobin) or hemolysis (hemoglobin) toxicity
Acute interstitial nephritis
result of medication. associated w/ fever, rash, eosinophilia plus hematuria
What gives you a pigmented granular cast?