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Flashcards in Nephrotic syndrome Deck (13):
1

Nephrin

forms interdigitations b/w interdigitations of podocyte foot processes

2

convection vs diffusion

convection: solvent drag takes particles across membrane (high-flow states). Diffusion= equilibration of gradients (low flow states)

3

how is protein reabsorbed?

intact and degraded in the PT

4

describe pathologic proteinuria

fixed amount. so it may be more concentrated when volume is lower

5

what are the four official signs of nephrotic syndrome? other unofficial signs?

3g/d proteinuria or urine prot:creat >2; hypoalbuminemia; edema; hypercholesterolemia; coagulopathy, endocrine, immune, etc

6

nephrosis vs nephritis: derangement, problem, EABV, edema, htn, cxr

low serum albumin, renal inflammation. peripheral edema, decreased GFR. decreased eabv, increased. significant, mild. sometimes htn, usually. normal heart, cardiomegaly/pulm edema

7

what are the two types of nephrotic patients?

pure nephrosis (albuminuria), nephrosis w/ nephritis (generalized proteinuria to such a degree they become hypoalbuminemic)

8

why is albumin filtered while larger macromolecule filtration decreases

podocyte effacement=less filtration surface, more tight fit, fewer large molecules. Albumin is increased due to loss in filter charge.

9

why do nephrotic pts have lipid problems

increased lipoprotein synthesis due to oncotic signal, hdl lost in urine, decreased LPL and LCAT. Albumin binds certain lipids to take them out of sol'n

10

hypercoagulability in nephrosis. Where? why/

Renal vein thrombosis. hemoconcentration, loss of protein s

11

What gene mutation is most likely in nephrotic syndrome

the one regulating nephrin: CD2AP

12

overfill theory: renin levels

low

13

how does nephrotic syndrome affect vit d?

you excrete vit d metabolites and so you get less GI Ca absorption so you increase PTH