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Flashcards in TIN and cystic Deck (10):
1

Three types of drug induced TIN

Analgesic, hypersensitivity (acute), NSAID

2

Analgesic

chronic, necrosis of papilla (acellularity, concave)

3

hypersensitivity

Type1 hypersens, IgE mediated w/ eosinophilia and some in urine. Damage is reversible

4

ARPKD

fusiform cysts. In children. Usually die. Fibrocystin protein

5

Medullary sponge dz

gravel in urine.

6

Protein associated with medullary cystic dz complex

nephrocystin (cytoplasmic). Also problematic in ADPKD

7

Genes at fault in ADPKD and what they encode

PKD1,2,3. Transmembrane genes (polycystin 1 and 2)

8

ADPKD: presentation

abdomen discomfort, perhaps a blow, hematuria, cysts on liver or colon or aneurysms.

9

ADPKD: pathogenesis

abnormal cell-matrix interaction, cell proliferation, fluid secretion (cAMP)

10

Problem with polycystin 1

FAK protein is missing so you can't associate with integrins