Flashcards in TIN and cystic Deck (10):
Three types of drug induced TIN
Analgesic, hypersensitivity (acute), NSAID
chronic, necrosis of papilla (acellularity, concave)
Type1 hypersens, IgE mediated w/ eosinophilia and some in urine. Damage is reversible
fusiform cysts. In children. Usually die. Fibrocystin protein
Medullary sponge dz
gravel in urine.
Protein associated with medullary cystic dz complex
nephrocystin (cytoplasmic). Also problematic in ADPKD
Genes at fault in ADPKD and what they encode
PKD1,2,3. Transmembrane genes (polycystin 1 and 2)
abdomen discomfort, perhaps a blow, hematuria, cysts on liver or colon or aneurysms.
abnormal cell-matrix interaction, cell proliferation, fluid secretion (cAMP)