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Flashcards in Nephritis Deck (15):
1

what are the three layers of the GBM?

LRI-LD-LRE

2

What is fractional clearance?

for macromolecules. The clearance of a given substance divided by clearance of inulin. If it equals 1, freely filtered. If it equals 0, impermeable

3

How do you determine clearance?

=urine conc times volume divided by plasma conc. Gives you the GFR when substance measured is creatinine or inulin

4

SGP

sialoglycoprotein, charge selectivity. on foot processes and endothelial surface

5

HS-PGs

heparan sulfate proteoglycan, charge and size selectivity. kind of inside lamina rara e/i

6

collagen and laminins provide what type of selectivity?

size

7

removal of sgp's does what to foot processes?

detachment from GBM

8

what attaches foot processes to GBM?

alpha and beta integrins

9

selective proteinuria vs nonselective

selective is just albumin and is seen in minimal change dz. nonselective is albumin and globulins, seen in other nephrtiides

10

five characteristics of nephrotic syndrome

proteinuria>3g/day. serum albumin300mg/dl. lipiduria, edema

11

six characteristics of nephritic state

hematuria (rbc/wbc casts), proteinuria, azotemia, oliguria, HYPERTENSION, edema

12

characteristics of complexes with antigen excess

soluble, high diffusion, subepithelial deposit, complement not fixed

13

characteristics of complexes with antibody excess

insoluble, low diffusion, subendothelial/mesangial deposit, fixed complement

14

what are the three scenarios for immune complex deposition. What happens next?

1)complex formed in circulation then deposited (lupus). 2)Intrinsic component of capillary (goodpastures, Heymann). 3) foreign antigen implants and is then complexed (poststrep. glom). Then complement is activated and PMN/monocytes destroy GBM

15

what diseases activate the alternate pathway?

IgA nephritis, post-strep, lupus, MPGN 2