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Flashcards in more nephritis Deck (13):
1

Mesangial cells: two fxns and what receptors do they have

contraction, phagocytosis. AT2 receptors

2

what is the mechanism for nephritic edema?

you get low GFR, so low tubular flow results in Na retention

3

where do positively charged complexes deposit?

GBM

4

DPLGN: histo findings. Electron microscopy?

karyorrhexis, wire loop lesions. subendothelial deposits, paracrystalline structures (fingerprints)

5

Post-strep GN: nephritic or nephrotic? H/O? Special findings? Kidney surface appearance?

nephritic, strep infection. Hypercellular glomeruli and Hump like deposits (C3 and IgG). heavy influx of PMN's (present in urine) Flea bitten (petichea)

6

IgA nephropathy: H/O?

Gross heamuria (URI, GI problems). Transplants.

7

Membranoproliferative Glomerulonephritis type 1: characteristic

hypercellular glomeruli with lobules and mesangial interposition (second BM)

8

Goodpasture's Syndrome (GPS): cause, progression, characteristics. Antigen?

Anti GBM, Crescentic GN (linear GBM immunoflourescence), rapidly progressing. GP antigen in the NC1 domain of type 4 collagen

9

Wagener's granulomatosis: triad? ANCA?

nasopharyngeal granuloma(nose bridge, giant cells), microscopic vasculitis, necrotizing glomerulonephritis. C-ANCA (PR3) (must be panca -)

10

P-ANCA: reacts w/? seen in?

MPO, crescentic glomerulonephritis. Perinuclear, popcorn appearance

11

Benign HTN: approx bp, age, contributing conditions, etiology. Endothelial appearance of arteries and arterioles?

>160/90, 60y/o, diabetes, kidney isnt sensitive to bp. second arterial EL, hyalinosis of arterioles

12

Malignant HTN: onset, lab findings, lesions

rapid onset, younger pts, high renin levels. necrotizing and hyperplastic arteriolitis (onion skinning)

13

Secondary HTN: main causes

renal artery stenosis causes ischemic kidney which secretes MORE RENIN (JGA hyperplasia)