Intro to Antihypertensive Agents I Flashcards Preview

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Flashcards in Intro to Antihypertensive Agents I Deck (44)
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31

thiazide diuretics

blocks Na/Cl cotransporter in the distal convoluted tubule

32

Ca reabsorption

distal convoluted tubules
-has Ca channels
-regulated by PTH

-increased PTH/increased reabsorption

33

most important site of K secretion**

collecting tubule
-site where all diuretic induced K balance changes occur

**most diuretics - hypokalemia - bc more sodium to CT lumen > more Na pulled out at ENaC > causes more K secretion**

**also hypokalemia with metabolic alkalosis > lumen negative favors retention of H+ in lumen > urine pH goes down > body pH goes up**

more Na to CT - more K secretion

34

collecting tubule

-proton pump - increased urine acidity
-ENaC - 2-5% Na reabsorption

creates electrical gradient that facilitates K secretion down concentration gradient

35

aldosterone

increased ENaC and basolateral Na/K ATPase in collecting tubule

water retention - increase in blood volume and BP

36

ENaC

in collecting tubule
-increased Na reabsorption
-2-5% of total
-does create gradient to facilitate K secretion

37

ADH

aka vasopression
-released from pituitary
-increases aquaporin 2 on collecting tubules
-via V2 receptor

-increased water reabsorption

38

ADH level control

serum osmolality and volume status

39

diuretics

-carbonic anhydrase inhibitors
-loop diuretics
-thiazide diuretics
-potassium-sparing diuretics

40

diuretic use

increase rate of urine flow

edematous and nonedematous states

41

site of loop diuretics

Na/K/2Cl cotransporter in thick ascending limb

42

site of thiazide diuretics

Na/Cl cotransporter

43

site of potassium sparing diuretics

sodium channels

44

site of potassium sparing diuretics

mineralocorticoid receptors

and sodium channels