Intro to Antihypertensive Agents V Flashcards Preview

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Flashcards in Intro to Antihypertensive Agents V Deck (50)
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31

beta2 bronchodilation

non-selective beta blockers
-relative contraindication

32

diabetes

don't want non-selective beta blocker

33

beta-blockers

no longer first line treatment for HTN

-except when with heart failure, recent MI, or reduced left ventr. function

34

labetalol

selective alpha 1 blocker
non-selective beta 1 and 2 blocker

partial agoninst at beta 2

-IV for severe HTN
-acceptable for HTN during pregnancy

35

carvedilol

non-selective beta-blocker and alpha-1 blocker

also antioxidant

36

nebivolol

beta1 selective blocker
-also decreases TPR and BP
-via increased nitric oxide formation

37

phenylephrine

alpha agonist
alpha 1 > alpha 2

38

beta blockers with vasodilator activity

non-selective - carteolol, carvedilol, labetalol

beta-1 selective - betaxolol, nebivolol

ex/ nebivolol - increases NO

39

esmolol

beta1 selective
-very rapid onset and short duration of action

IV for peri-op tachycardia and HTN, hypertensive emergencies, arrhythmias

also used in electroconvulsive therapy

aka brevibloc

40

prazosin

alpha-1 selective blocker
-no loss of alpha2 inhibition on NE release

admin of phenylephrine - no effect

41

phentolamine

non-selective alpha blocker
-decreased alpha 2 inhibitor
-therefore larger increase of NE release

42

men with HTN and BPH

alpha-1 selective blocker
-prazosin

43

clonidine receptor agonist

clonidine

44

clonidine

alpha 2 receptor agonist
-central acting

increased BP, then decreased BP**

sudden withdrawal - hypertensive crisis

45

dangerous effect on fetus

ACE (-)
-ends in pril

46

methyldopa

converted to methyl-NE
-stored in NE vesicles

central alpha2 agonist
-decreased sympathetic outflow
-decreased BP

-treat HTN in pregnancy***

aka aldomet

47

hypertensive emergency

involves organ damage

drugs given IV

48

renoprotective

ACE (-) or ARBs

49

no used unless specific indication

beta-blockers

50

african descent

ARB and ACE (-) worse