Intro to inflammation Flashcards Preview

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Flashcards in Intro to inflammation Deck (15)
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1
Q

Is inflammation part of the innate or delayed immune response?

A

Innate

2
Q

What are some of the beneficial effects of inflammation?

A

Delivery of immune cells and proteins
Dilution of toxins
Eliminate substance & allow tissue repair
or
Stimulate further response
Entry of drugs
Excessive inflammation - Arthritis, syphyillis, lyme

3
Q

During inflammation, what can vascular changes such as vasodilation result in?

A

Erythema
Warmth
Oedema

4
Q

During inflammation, what can vascular changes such as increased permeability result in?

A
Inc exudate (fluid and proteins)
Inc emigration of inflamm cells
5
Q

What immune cells will do phagocytosis in inflammatioin?

A

Neutrophils

6
Q

What are the causes of chronic inflammation?

A
Persisting infection
Persisting foreign bodies
Inadequate response
Prolonged toxin exposure
Persisting trauma
Auto-immune
7
Q

What are some of the microscopic features of chronic inflammation?

A

New leukocytes (lymphocytes and macrophages)
Tissue destruction
Attempts at healing
Involves adaptive immunity

8
Q

When can leukocytosis occur? (inc in leukocytes)

A

In acute and chronic inflammation

9
Q

What are some patterns of inflammation?

A

Granulomas
Ulcers
Serous & Fibrinous
Suppurative - pus forming (purulent exudate)

10
Q

What is granulomatous inflammation and what can cause it? Does it occur in chronic or acute iflamm or both?

A
Granulomas = collections of macrophages
Mycobacteria, especially tuberculosis
Foreign material
Sarcoidosis
Chronic and acute
11
Q

What are ulcers, give examples? Does it occur in chronic or acute iflamm or both?

A
Break in epithelial surface 
Acute or chronic
Aphthous ulcers
Peptic ulcers 
Ulcerative colitis
12
Q

In serous and fibrinous inflam, which is acute and which is chronic? e.g.blister

A

Serous - acute

Fibrinous - chronic

13
Q

What immune cells are present in purulent exudate (supprative)?

A

neutrophils

14
Q

What are the macro and microscopic features of crohn’s disease?

A
Macro:
Can affect anywhere
Bowel thickened, ulcers & fissures 
Cobblestoning
Fistulae
Abscesses 
Micro:
Transmural inflammation
Patchy, skip lesions 
Chronic inflammatory cells predominate
Granulomas
15
Q

What are the macro and microscopic features of ulcerative colitis?

A
Macro:
Colon only
Inflammation & ulceration
Pseudopolyps 
Micro:
Superficial inflammation
Chronic inflammatory cell infiltrate
Crypt abscesses and cryptitis 
Continuous inflammation