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Flashcards in Intro to inflammation Deck (15)
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1

Is inflammation part of the innate or delayed immune response?

Innate

2

What are some of the beneficial effects of inflammation?

Delivery of immune cells and proteins
Dilution of toxins
Eliminate substance & allow tissue repair
or
Stimulate further response
Entry of drugs
Excessive inflammation - Arthritis, syphyillis, lyme

3

During inflammation, what can vascular changes such as vasodilation result in?

Erythema
Warmth
Oedema

4

During inflammation, what can vascular changes such as increased permeability result in?

Inc exudate (fluid and proteins)
Inc emigration of inflamm cells

5

What immune cells will do phagocytosis in inflammatioin?

Neutrophils

6

What are the causes of chronic inflammation?

Persisting infection
Persisting foreign bodies
Inadequate response
Prolonged toxin exposure
Persisting trauma
Auto-immune

7

What are some of the microscopic features of chronic inflammation?

New leukocytes (lymphocytes and macrophages)
Tissue destruction
Attempts at healing
Involves adaptive immunity

8

When can leukocytosis occur? (inc in leukocytes)

In acute and chronic inflammation

9

What are some patterns of inflammation?

Granulomas
Ulcers
Serous & Fibrinous
Suppurative - pus forming (purulent exudate)

10

What is granulomatous inflammation and what can cause it? Does it occur in chronic or acute iflamm or both?

Granulomas = collections of macrophages
Mycobacteria, especially tuberculosis
Foreign material
Sarcoidosis
Chronic and acute

11

What are ulcers, give examples? Does it occur in chronic or acute iflamm or both?

Break in epithelial surface
Acute or chronic
Aphthous ulcers
Peptic ulcers
Ulcerative colitis

12

In serous and fibrinous inflam, which is acute and which is chronic? e.g.blister

Serous - acute
Fibrinous - chronic

13

What immune cells are present in purulent exudate (supprative)?

neutrophils

14

What are the macro and microscopic features of crohn's disease?

Macro:
Can affect anywhere
Bowel thickened, ulcers & fissures
Cobblestoning
Fistulae
Abscesses
Micro:
Transmural inflammation
Patchy, skip lesions
Chronic inflammatory cells predominate
Granulomas

15

What are the macro and microscopic features of ulcerative colitis?

Macro:
Colon only
Inflammation & ulceration
Pseudopolyps
Micro:
Superficial inflammation
Chronic inflammatory cell infiltrate
Crypt abscesses and cryptitis
Continuous inflammation