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Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
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90

Renal-cell carcinoma, papillary type: Cytokeratins.

CK7 is expressed by 80% of tumors of type I and by 20% of tumors of type II.

91

Renal-cell carcinoma, papillary type: Additional immunohistochemical stains (3).

Positive: RCC antigen, CD10, PAX8.

92

Renal-cell carcinoma, papillary type: Mutations (3).

+7, +17, -Y.

No mutation of VHL.

93

Renal-cell carcinoma, chromophobe type: Syndrome.

Birt-Hogg-Dubé syndrome.

94

Renal-cell carcinoma, chromophobe type: Histopathology.

Thick cell membranes resembling walls of plant cells.

Koilocyte-like wrinkled nuclei with halo.

Thick-walled, hyalinized blood vessels.

95

Renal-cell carcinoma, chromophobe type: Histopathologic types.

Classic: Pale cytoplasm.

Eosinophilic: Intensely eosinophilic cytoplasm.

96

Renal-cell carcinoma, chromophobe type: Electron microscopy (2),

Classic: Many microvesicles.

Eosinophilic: Many mitochondria.

97

Renal-cell carcinoma, chromophobe type vs. oncocytoma: Stains (3).

Renal-cell carcinoma, chromophobe type . . .

− CK7, Hale's colloidal iron: Diffusely positive.
− S100A1: Not expressed.

98

Renal-cell carcinoma, chromophobe type: Prognosis.

Significantly better than that of clear-cell RCC.

99

Multilocular cystic renal-cell carcinoma: Gross pathology.

Concysts entirely of sists filled with serous or hemorrhagic fluid.

100

Multilocular cystic renal-cell carcinoma: Histopathology.

Cysts are lined by one layer of epithelium.

Fibrous septa contain small clusters of clear cells.

101

Multilocular cystic renal-cell carcinoma vs. renal-cell carcinoma with cystic change.

The former contains no solid, expansile tumor nodules of any size.

102

Multilocular cystic renal-cell carcinoma: Prognosis.

Excellent.

103

Carcinoma of the collecting ducts: Location.

Medulla.

104

Carcinoma of the collecting ducts: Histopathologic architecture (2).

Tubular or tubulopapillary structures with tapered ends.

Inflamed desmoplastic stroma.

105

Carcinoma of the collecting ducts: Cytology (4).

High-grade nuclei.

Hobnail appearance of cells that line glands.

Many mitotic figures.

Cytoplasm may contain mucin.

106

Carcinoma of the collecting ducts: Adjacent renal tissue.

Shows epithelial dysplasia.

107

Carcinoma of the collecting ducts: Immunohistochemistry (5,1).

Positive: HMWCK, CK7, CEA, peanut agglutinin, Ulex europaeus agglutinin.

Negative: CD10.

108

Carcinoma of the collecting ducts vs. papillary renal-cell carcinoma: Immunohistochemistry.

Papillary renal-cell carcinoma does not express HWMCK or Ulex europaeus agglutinin.

109

Carcinoma of the collecting ducts vs. urothelial carcinoma with glandular differentiation.

Urothelial carcinoma with glandular differentiation is more likely if the tumor arises in the calyces or the renal pelvis.

110

Carcinoma of the collecting ducts: Prognosis.

Poor; one third of patients present with metastases.

111

Renal medullary carcinoma: Epidemiology.

Near all patients have sickle-cell trait or the disease.

Patients are typically under 40 years old.

112

Renal medullary carcinoma: Gross pathology.

Arises in the medulla but tends to extend into the calyces and often into the perinephric fat.

113

Renal medullary carcinoma: Histopathologic patterns (3).

Areas that resemble yolk-sac tumor at low power.

Areas that resemble adenoid-cystic carcinoma.

Solid sheets.

114

Renal medullary carcinoma: Cytology.

Poorly differentiated cells with vesicular nuclei and a large nucleolus.

115

Renal medullary carcinoma: Stroma.

Desmoplastic and inflamed and may contain mucin or edema.

116

Renal medullary carcinoma: Blood vessels.

Contain sickle cells.

Usually invaded by the tumor.

117

Renal medullary carcinoma: Immunohistochemistry (1,2).

Positive: Cytokeratins.

Negative: HMWCK, INI-1.

118

Renal medullary carcinoma: Prognosis.

Most patients are dead within 1 year.

119

Mucinous tubular and spindle-cell carcinoma:

A. Presentation.
B. Behavior.

A. Usually asymptomatic.

B. Low-grade carcinoma with a good prognosis.