L3: Bronchial Asthma

Question 1

Cells Responsible for acute asthma

Answer 1

Mast Cells

Question 2

Cells Responsible for Chronic asthma

Answer 2

Eosinophils

Question 3

Cells Responsible for Exacerbation iof Asthma

Answer 3

Mast Cells

Question 4

Cells Responsible for Airway Remodiling

Answer 4

Eosinophils

Question 5

Clinical clues in diagnosis of asthma

Answer 5

Question 6

Management of Bronchial Asthma

Answer 6

• Determine type of patient (naïve or on controller)
• Determine level of control.
• 5 steps of treatment according to level of control.

Question 7

Management of Bronchial Asthma

• Determine Type of Patient

Answer 7

Question 8

Determine Type of Patient in Bronchial Asthma

• Naive

Answer 8

Question 9

Determine Type of Patient in Bronchial Asthma

• On Controller

Answer 9

Question 10

Determine Level of Control in Bronchial Asthma

Answer 10

Question 11

Determine Level of Control in Bronchial Asthma

• Controlled

Answer 11

Question 12

Determine Level of Control in Bronchial Asthma

• Partially Controlled

Answer 12

Question 13

Determine Level of Control in Bronchial Asthma

• Uncontrolled

Answer 13

Question 14

Duration of treatment in acute attack of Bronchial asthma

Answer 14

Question 15

Pharmacologic TTT of Bronchial Asthma

Answer 15

Question 16

Pharmacologic TTT of Bronchial Asthma

• Reliever (Rescue) Medications

Answer 16

Question 17

Pharmacologic TTT of Bronchial Asthma

• Controller Medications

Answer 17

Question 18

MOA of ICS in Bronchial Asthma

Answer 18

• Block late asthmatic response to allergens
• ⇣⇣ airway hyper responsiveness
• ⇣⇣ cytokine production
• ⇣⇣ adhesion protein activation
• ⇣⇣inflammatory cell migration & activation.
• Reverse β2 receptor down regulation and sub sensitivity

Question 19

MOA of Leukotriene Modifiers in Bronchial Asthma

Answer 19

Either 5-lipoxygenase inhibitors / leukotriene-receptor antagonists

Question 20

Indications of Leukotriene Modifiers in Bronchial Asthma

Answer 20

They are add on therapy or alternative to steroids

Question 21

MOA of Monoclonal anti-IgE Ab in Bronchial Asthma

Answer 21

Binds selectively to human IgE on surface of mast cells and basophils.

Question 22

Indications of Monoclonal anti-IgE Ab in Bronchial Asthma

Answer 22

• Indicated for moderate – severe persistent asthma in whom symptoms are not controlled by ICS

Question 23

Indications of Inhaled corticosteroid in Bronchial Asthma

Answer 23

◈ long-term control of symptoms

◈ Suppression, control, and reversal of inflammation

Question 24

Indications of Systemic corticosteroid in Bronchial Asthma

Answer 24

◈ Short courses (3 – 10 d) —-> Control of acute asthmatic episodes

◈ Long-term prevention of symptoms in severe persistent asthma

Question 25

TTT of **Bronchial Asthma** - Step 1

Answer 25

Question 26

TTT of **Bronchial Asthma** - Step 2

Answer 26

Question 27

TTT of **Bronchial Asthma** - Step 3

Answer 27

Question 28

TTT of **Bronchial Asthma** - Step 4

Answer 28

Question 29

TTT of **Bronchial Asthma** - Step 5

Answer 29

Question 30

Allergen-specific Immunotherapy

Answer 30

Question 31

Def of **Asthma Exacerbation**

Answer 31

Question 32

Def of **Status asthmaticus**

Answer 32

Question 33

CP of **Asthma Exacerbation**

Answer 33

Question 34

CP of **Asthma Exacerbation** - Common Symptoms

Answer 34

Question 35

CP of **Asthma Exacerbation** - Vitals

Answer 35

Question 36

CP of **Asthma Exacerbation** - Signs of Bronchoconstriction

Answer 36

Question 37

CP of **Asthma Exacerbation** - Increased WOB

Answer 37

Question 38

TTT of **Asthma Exacerbation**

Answer 38

Question 39

TTT of **Asthma Exacerbation** - If no response

Answer 39

Question 40

Read the rest of the lecture well

Answer 40

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