L9: Chronic Hepatitis Flashcards by Ahmed Farag

Q

Def of Chronic Hepatitis

A

Continuous inflammatory lesion of the liver for 6 months.

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Q

Liver biopsy is essential in the assessment of patients

A

…..

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Q

Fate of Chronic Hepatitis

A

Progress to more severe disease
Continue unchanged.
Subside spontaneously or with treatment

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Q

Etiology of Chronic Hepatitis

A

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Q

Etiology of Chronic Hepatitis

Infectious Agents

A

HBV
HCV
CMV
EBV

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Q

Etiology of Chronic Hepatitis

Autoimmune

A

…..

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Q

Etiology of Chronic Hepatitis

Metabolic/Genetic

A

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Q

Etiology of Chronic Hepatitis

Drugs

A

Paracetamol
Nitrofurantoin
Methotrexate
Depakin

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Q

Etiology of Chronic Hepatitis

Toxins

A

Pollution
Aflatoxin

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Q

CP of Chronic Hepatitis

A

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Q

Dx of Chronic Hepatitis

A

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Q

Clinical features suggesting chronicity

A

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Q

Clinical features suggesting chronicity

Features of chronic liver disease at presentation

A

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Q

investigations suggesting chronicity

A

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Q

investigations suggesting chronicity

Labs

A

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Q

investigations suggesting chronicity

Abdominal US

A

impaired portal flow

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Q

investigations suggesting chronicity

Liver Bx

A

Corner stone - not pathognomonic

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Q

Signs of Chronic Liver Disease

A

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Q

CP of HBV

A

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Q

CP of HBV

Aysmptomatic Carrier

A

Act as a reservoir for infection

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Q

CP of HBV

Symptomatic “Hepatic”

A

Fatigue
Anorexia
Vague Upper Abdominal Pain

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Q

CP of HBV

Extra-Hepatic

A

Glomerulonephritis “membranoproliferative”
Polyarthritis nodosa
Cryoglobulinemia “essential mixed”
Aplastic anemia
Vasculitis

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Q

CP of HBV

Cirrhosis

Study These Flashcards

A

…..

Q

INVx for HBV

Study These Flashcards

A

INVx for **HBV** - Scheme

INVx for **HBV** - Serology

INVx for **HBV** - Virology

HBV DNA

INVx for **HBV** - Liver Enzymes

Transaminases: Normal or increased "Mild to moderate"

Phases of **HBV** Infection ----> Comment on ALT, HBV DNA, Anti-HBc, HBsAg, Anti HBs, HBeAg, Anti HBe

Phases of **HBV** Infection ----> Comment on ALT, HBV DNA, Anti-HBc, HBsAg, Anti HBs, HBeAg, Anti HBe - Acute Infection

Phases of **HBV** Infection ----> Comment on ALT, HBV DNA, Anti-HBc, HBsAg, Anti HBs, HBeAg, Anti HBe - Chronic Infection

Phases of **HBV** Infection ----> Comment on ALT, HBV DNA, Anti-HBc, HBsAg, Anti HBs, HBeAg, Anti HBe - Resolved Infection

TTT of **HBV**

TTT of **HBV** - Interferon Alpha

MOA of Interferon Alpha in HBV

Dose of **Interferon Alpha in HBV**

Duration of **Interferon Alpha in HBV**

Factors Associated with Increased Response to **Interferon Alpha in HBV**

SE of **Interferon Alpha in HBV**

CI of **Interferon Alpha in HBV**

TTT of **HBV** - Lamivudine "Zeffi"

Monitoring of **Interferon Alpha in HBV**

Indications for TTT of **HBV**

TTT of **HBV** - Theray is not Indicated Into.....

TTT of **HBV** - Sequence of biochemical & serological events in responders

TTT of **HBV** - Factors affecting the clinical course of HBV infection

CP of **HCV**

As HBV

Pathology in **HCV**

INVx for **HCV**

INVx for **HCV** - Scheme

INVx for **HCV** - Labs

TTT of **HCV**

TTT of **HCV** - Drugs

TTT of **HCV** - Indications

TTT of **HCV** - Goals

Prognosis of **HCV**