Flashcards in Laboratory diagnostics of liver disease Deck (9)
What are the enzymes that indicate liver damage?
-Alanine aminotransferase (ALT)
-Sorbitol dehydrogenase (SDH)
-Glutamate dehydrogenase (GLDH)
Which liver enzymes are used in small and large animals?
ALT - dogs and cats
LA have low hepatic ALT so use SDH and GLDH instead
How can liver damage vs. muscle damage be distinguished when AST is high?
Check creatine kinase which will be increased 1-2 hours after muscle injury but will decrease over the next 24-48 hours so if it is persistently elevated then it indicates the increase ALT/AST are from muscle.
Which enzymes indicate cholestasis?
Alkaline phosphatase (ALP)
Gammaglutamyl transferase (GGT)
What is the significance of increase ALP in:
a) may be due to iatrogenic steroids or stressed animal
b) always significant
If GGT is found in urine of LAs what does this indicate?
Renal tubular cell damage
What is the significance of bilirubinuria in a:
a) normal if low levels in dog
b) significant finding in cats
What does decreased urea + increased ammonia indicate?
Hepatic disease - as ammonia not being converted to urea