Laboratory diagnostics of liver disease Flashcards Preview

Alimentary > Laboratory diagnostics of liver disease > Flashcards

Flashcards in Laboratory diagnostics of liver disease Deck (9)
1

What are the enzymes that indicate liver damage?

-Alanine aminotransferase (ALT)
-Aspartate aminotransferase(AST)
-Sorbitol dehydrogenase (SDH)
-Glutamate dehydrogenase (GLDH)

2

Which liver enzymes are used in small and large animals?

ALT - dogs and cats

LA have low hepatic ALT so use SDH and GLDH instead

3

How can liver damage vs. muscle damage be distinguished when AST is high?

Check creatine kinase which will be increased 1-2 hours after muscle injury but will decrease over the next 24-48 hours so if it is persistently elevated then it indicates the increase ALT/AST are from muscle.

4

Which enzymes indicate cholestasis?

Alkaline phosphatase (ALP)
Gammaglutamyl transferase (GGT)

5

What is the significance of increase ALP in:
a) dogs
b) cats

a) may be due to iatrogenic steroids or stressed animal
b) always significant

6

If GGT is found in urine of LAs what does this indicate?

Renal tubular cell damage

7

What is the significance of bilirubinuria in a:
a) dog
b) cat

a) normal if low levels in dog
b) significant finding in cats

8

What does decreased urea + increased ammonia indicate?

Hepatic disease - as ammonia not being converted to urea

9

What is the significance of fluctuations in cholesterol for liver pathology?

It normally fits a pattern but is not diagnositic.

Increases - cholestasis as decreased excretion
Decreases - hepatic failure due to decreased synthesis