Lec 19 Ketone Metabolism

Question 1

liver maintains blood glucose homestasis in the fasted state by blank and blank

Answer 1

glycogenolysis, gluconeogenesis

Question 2

important glucose precursor that can be used by liver

Answer 2

oxaloacetate

Question 3

fasted state causes oxaloacetate to leave the blank cycle and get involved in blank

Answer 3

tca, gluconeogenesis

Question 4

triglycerides are broken down by blank in the fasted state which is activated by pka

Answer 4

hsl

Question 5

increased epinephrine and glucagon are required for the triggered increase in blank in the fasted state

Answer 5

PKA

Question 6

lipolysis results in this products

Answer 6

three fatty acid, 1 glycerol

Question 7

HMG coA synthetase is induced in the blank state and is the rate limiting step of blank

Answer 7

fed, ketogenesis

Question 8

acetoacetate goes through a redox reaction to create blank which is metabolizable

Answer 8

beta hydroxybutyrate

Question 9

state of starvation starts blank

Answer 9

ketogenesis

Question 10

acetone breath is due to blank

Answer 10

starvation/diabetes/hypoglycemia

Question 11

hydrogen and methane breath is due to blank

Answer 11

carb intolerance

Question 12

what organ does most ketogenesis

Answer 12

liver (90%)

Question 13

hormone sensitive lipase (HSL) triggers breakdown of blank

Answer 13

triglyceride

Question 14

HSL is activated by blank

Answer 14

PKA

Question 15

HSL is used in this state

Answer 15

fasted

Question 16

four causes of acidosis

Answer 16

starvation ketosis(low insulin), diabetic ketosis(low insulin), alcoholism(epinephrine), low carb diet ketosis (low oaa)

Question 17

glut 1 deficiency is treated by ketogenic diet and is called blank

Answer 17

de vivo disease

Question 18

ketone body is beta hydroxybutyrate… evil twin is

Answer 18

GHB (gamma hydroxybutyrate)