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Dental Biochemistry > Block 3 - Lec 36 - Hemoglobin / Globin Genes > Flashcards

Block 3 - Lec 36 - Hemoglobin / Globin Genes Flashcards

1
Q

functional human hemoglobins all contain blank of two dissimilar blank chains

A

tetramers, globin

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2
Q

adult and fetal hemoglobin have blank alpha subunits

A

alpha

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3
Q

embryonic hemoglobin have blank beta subunits

A

epsilon

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4
Q

there are multiple blank for hemoglobin…. kind of like collagen

A

gene families

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5
Q

at birth there is no blank hemoglobin

A

embryonic

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6
Q

fetal hemoglobin goes away after about blank of life

A

1 year

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7
Q

alpha globin family is on this chromosome

A

16

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8
Q

beta gloin family is on this chromosome

A

11

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9
Q

sickle cell anemia is caused by a blank mutation from a blank base change

A

missense, single

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10
Q

Hb S is blank

A

sickle cell

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11
Q

sickle cell is from blank replacing blank codon and a blank residue replacing a blank residue in the protein

A

GUG, GAG, valine, glutamate

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12
Q

local anesthesia is blank for sickle cell patients

A

safe

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13
Q

general anesthesia is blank for sickle cell patients

A

dangerous

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14
Q

most hemoglobin variants are due to blank

A

single aa subsitutions (structural changes)

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15
Q

another alteration in hemoglobin that has changed quantitative expression

A

thalassemias

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16
Q

thalasemia is most common in blank population

A

mediterranean (greek, italian)

17
Q

individuals who carry a thalassemia gene fail to produce the normal quantity of one or more blank

A

globin chains

18
Q

most of the hemoglobin in adults (95%) is blank

A

Hb A

19
Q

two types of thalassemia and are insufficient produciton of these globins

A

alpha, beta

20
Q

more levels of thalassemia

A

1,2,3,4

21
Q

mild anemia no big deal

A

1

22
Q

anemia that can still live a normal life

A

2

23
Q

anemia that has excess beta globin and thus Hb H disease with a shorter lifespan

A

3

24
Q

anemia that is incompatible with life and results in dead fetus

A

4

Dental Biochemistry (43 decks)

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