Block 3 - Lec 36 - Hemoglobin / Globin Genes Flashcards Preview

Dental Biochemistry > Block 3 - Lec 36 - Hemoglobin / Globin Genes > Flashcards

Flashcards in Block 3 - Lec 36 - Hemoglobin / Globin Genes Deck (24):
1

functional human hemoglobins all contain blank of two dissimilar blank chains

tetramers, globin

2

adult and fetal hemoglobin have blank alpha subunits

alpha

3

embryonic hemoglobin have blank beta subunits

epsilon

4

there are multiple blank for hemoglobin.... kind of like collagen

gene families

5

at birth there is no blank hemoglobin

embryonic

6

fetal hemoglobin goes away after about blank of life

1 year

7

alpha globin family is on this chromosome

16

8

beta gloin family is on this chromosome

11

9

sickle cell anemia is caused by a blank mutation from a blank base change

missense, single

10

Hb S is blank

sickle cell

11

sickle cell is from blank replacing blank codon and a blank residue replacing a blank residue in the protein

GUG, GAG, valine, glutamate

12

local anesthesia is blank for sickle cell patients

safe

13

general anesthesia is blank for sickle cell patients

dangerous

14

most hemoglobin variants are due to blank

single aa subsitutions (structural changes)

15

another alteration in hemoglobin that has changed quantitative expression

thalassemias

16

thalasemia is most common in blank population

mediterranean (greek, italian)

17

individuals who carry a thalassemia gene fail to produce the normal quantity of one or more blank

globin chains

18

most of the hemoglobin in adults (95%) is blank

Hb A

19

two types of thalassemia and are insufficient produciton of these globins

alpha, beta

20

more levels of thalassemia

1,2,3,4

21

mild anemia no big deal

1

22

anemia that can still live a normal life

2

23

anemia that has excess beta globin and thus Hb H disease with a shorter lifespan

3

24

anemia that is incompatible with life and results in dead fetus

4