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Flashcards in Leprosy Deck (24):
1

causative agent of leprosy

Mycobacterium leprae

2

another name for leprosy

Hansen's disease

3

true or false: Leprosy has no acute illness

true

4

Which is false about M.leprae?
a. Waxy coating
b. able to grow in vitro
c. transmission is by nasal/oral droplets & dermal
inoculations
d. mainly a granulomatous disease

B

lack of genes needed for independent growth; need nude mice and nine-banded armadillos for
animal models

5

Pick which cannot be done for diagnosis of M.leprae
A.serologic test
B.skin biopsy
C.look for clinical signs
D.test for peripheral nerve thickening and tenderness

A

6

identify: primary external sign of Hansen's disease

skin lesions

7

true or false: Leprosy can cause body parts to fall off

false

however:
Tissues are numb --> microbial invasion --> secondary infection --> weakens the body’s defenses

8

Explain M.leprae's nerve damage mechanism

entry through blood vessels-->inflammatory response -->demyelination

9

stain used for skin smear test (M.leprae)

Ziehl Neelsen Carbol Fuschin Stain

10

Which is the more severe skin lesion, tuberculoid or lepromatous?

lepromatous

11

Where are many erythematous macules found?
A. tuberculoid
B. lepromatous
C. both A and B

B

12

Where can nerve enlargement be found?
A. tuberculoid
B. lepromatous
C. both A and B

A

13

Where can Langerhans cells be found?
A. tuberculoid
B. lepromatous
C. both A and B

A

14

Where does one experience Hypergammaglobulinemia?
A. tuberculoid
B. lepromatous
C. both A and B

B

15

Where does one experience erythema nosodum?
A. tuberculoid
B. lepromatous
C. both A and B

B

16

Which classification system groups leprosy cases as paucibacillary and bacillary?
A. 2009 WHO Classification System
B. Ridley – Jopling System
C. both of the above
D. none of the above

A

17

Define "paucibacillary"

skin lesions with no bacilli seen in a skin smear

18

__= Key to Progression

Fill in the blank

late treatment

19

Dapsone, a drug used to treat leprosy, inhibits this substance. Identify.

dihydropteroate synthase

20

Dapsone inhibits ___ synthesis

nucleic acid

21

Rifampicin inhibits synthesis of
A. DNA
B. RNA
C. both A and B

B

22

False about Type 1/Borderline leprosy
A. Delayed hypersensitivity occurring at the site of
localized M. leprae antigens
B. Skin lesions appear and are erythematous
C. Peripheral nerves become tender and painful
D. Loss of nerve function is gradual

D

it can be sudden

23

In Type 2/Borderline Lepromatous and Lepromatous cases, What results from
immune complex deposition?

Erythema nodusum leprosum (ENL)

24

All of the ff are final 3 countries that have leprosy, except:
A.Brazil
B.Egypt
C.Nepal
D.Timor-Leste

b