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PH 152 > Leptospirosis > Flashcards

Leptospirosis Flashcards

0
Q

How is L.interrogans transferred?

A

Contact of mucous membranes or broken skin with water/soil that’s contaminated with urine of infected animal

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1
Q

Causative agent of leptospirosis

A

Leptospira interrogans

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2
Q

In viewing L.interrogans, darkfield microscopy is not required. T or F?

A

F

Darkfield- required

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3
Q

Philippines has __ incidence of leptospirosis
A. Low
B. Moderate
C. High

A

B

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4
Q

After it enters the body, it multiplies in blood and tissue. This may lead to __ aka inflammation of blood vessel

A

Vasculitis

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5
Q

Which is not a vital pathogenic property of leptospira?
A. Adhesion
B. Enterotoxin
C. Cellular toxicity

A

b

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6
Q

What is the major surface lipoprotein in Leptospira pathogenic serovars? It is involved in pathogenesis of tubulointerstitial nephritis

A

LipL32

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7
Q

Which is false?
A.Pulmonary involvement of leptospira is the result of inflammation
B.Many Leptospira-infected people are asymptomatic
C.Among symptomatics, 90% are mild
D.When L.interrogans affects liver, centrilobular necrosis may occur

A

F

Result of hemorrhage siya

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8
Q

Identify the lepto phase

Invasion or persistence of pathogenic bacteria in blood stream

A

Septicemic phase

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9
Q

Identify the lepto phase

Antibody prod + excretion of leptospires @ urine

A

Immune phase

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10
Q

the lepto patient is experiencing conjunctival suffusion; classify
A. Mild
B. Moderate
C. Severe

A

A

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11
Q

the lepto patient is experiencing oliguria; classify
A. Mild
B. Moderate
C. Severe

A

B

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12
Q

the lepto patient is experiencing hepatic necrosis; classify
A. Mild
B. Moderate
C. Severe

A

C

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13
Q 
Which lepto cases needs to be hospitalized?
A. Mild
B. Moderate
C. Severe
D. B and C
E. A,B & C
A

D

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14
Q

The ff are WHO lepto diag criteria except
A.positive leptospiral culture of the blood and/or urine
B.high positive single lepto Microagglutination Test (MAT) titer of 1:1600
C.Seroconversion from initial MAT negative to a positive antibody titer
D.twofold rise in antibody titers by MAT from acute to convalescent.

A

D

fourfold dapat

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15
Q

Gold standard of diagnosis for lepto

A

Culture isolation

16
Q 
Any of the ff media may be used for lepto culture except
A.EMJH
B.Fletcher's
C.Lowenstein Jensen
D.none of the 3
A

C

17
Q

Identify the detection method
Utilizes live antigens of leptospires (nonpathogenic) as reagent against patients’ serum and examined under dark field for agglutination

A

Microagglutination Antibody Test

18
Q

Genus specific MAT uses __ as live antigen

A

Leptospira biflexa

19
Q

Genus specific MAT positive cutoff in country

A

1:1600

20
Q

Criteria whose diagnosis is based on clinical, epid and lab data

A

Faine’s criteria

21
Q

Drug of choice for anicteric lepto

A

Doxycycline

22
Q

Postulated etiology of Jarrisch-Herxheimer reaction

A

this is an inflammatory process that results from activation of the cytokine cascade (increase IL-1 and IL-6)

23
Q

For pregnant patients, preexposure prophy is recommended to reduce their risk of getting infected. T or F?

A

F

24
Q

JL is a pedicab driver who has to feed 6 kids and a wife. During the rainy season, he has to wade through floodwater everyday to get his passengers through Taft Ave. what is his risk exposure assessment?
A.low
B.moderate
C.high

A

C

25
Q

RB is a student living in Alabang.It was raining hard & to get to the bus, she had to wade in flood water. She was wearing slippers but her feet had no wounds.what is her risk exposure assessment?
A.low
B.moderate
C.high

A

A

26
Q

T or F

Corticosteroids reduce mortality and change outcome significantly when used in early in management of pulmo lepto

A

T

27
Q

___ with non-invasive ventilation is life-saving in ARDS owing to leptospirosis

A

Methylprednisolone

28
Q

The ____of endemic leptospiral strains complicates the development of vaccine that can be used worldwide.

A

local variability in serovars

PH 152 (47 decks)

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