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PH 152 > Herpesviridae > Flashcards

Herpesviridae Flashcards

0
Q

Enumerate the members of Alphaherpesvirinae.Where does their latency happen?

A

HSV1,HSV2,VSV/HSV3

Neurons

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1
Q 
Which is not a property of Herpesviridae?
A)Capsid with helical symmetry 
B)Enveloped
C)Double stranded DNA viruses 
D)Only viruses assembled in the nucleus
A

A

Icosahedral dapat

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2
Q

Enumerate the members of Betaherpesvirinae. What is their common feature?

A

CMV, HHV6/HHV7

long periods of growth

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3
Q 
Where does CMV produce latent infection?
A.glands
B.kidneys
C.neurons
D. A and B
E. B and C
A

D

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4
Q 
Where do HHV6 & HHV7 produce latent infection?
A.glands
B.lymphoid tissue
C.neurons
D. A and B
E. B and C
A

B

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5
Q

Enumerate members of Gammaherpesvirinae. Where do they commence their latency?

A

Epstein-Barr Virus & Kaposi sarcoma- associated herpesvirus

Lymphoid tissue

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6
Q

False about Herpes Simplex Virus
A. HSV1 & HSV2 have same characteristics (50-70%)
B. They antigenically cross-react with VZV
C. They are zoonotic

A

C

Humans only: natural host

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7
Q

How is herpes simplex virus transmitted?

A

Spread by contact; virus is shed in saliva, tears, genital and other secretions

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8
Q

Is this an accurate initial pathogenesis of HSV?

spreads locally –>short-lived viraemia (spread in the bloodstream) occurs –> dissemination in the body

A

Yes

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9
Q

Where does latency of HSV exactly occur?

A

Craniospinal ganglia

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10
Q 
Encephalitis, conjunctivitis, esophagitis,  Herpes gladiatorum & Tracheobronchitis - in what HSV can these be found?
A. HSV1
B. HSV2
C. HSV3
D. All 3
A

A

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11
Q

Meningitis, perianal herpes may be found in
A. HSV1
B. HSV2
C. Both

A

B

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12
Q

Gingivostomatitis, tonsillitis, labialis, pharyngitis, genital herpes, Herpes whitlow may be found in
A. HSV1
B. HSV2
C. Both

A

C

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13
Q

• Most common manifestation of primary herpes infection

A

Acute Gingivostomatitis (‘singaw’)

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14
Q

Identify
• Recurrence of oral HSV
• A prodrome of tingling, warmth or itching at the site usually heralds the recurrence
• About 12 hours later, redness appears followed by papules and then vesicles

A

Herpes labialis/cold sore

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15
Q 
Herpes simplex virus does not manifest in the:
A. eye
B. ear
C. genitals
D. brain
A

B

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16
Q

IV acyclovir is given in all cases
of suspected HSE before lab results are available.
True or False?

A

True

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17
Q

identify the HSV manifestation
arises from implantation of the virus
into the skin, typically affects the fingers

A

herpes whitlow

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18
Q 
Which diagnostic method can distinguish between HSV and VSV?
A. Electron microscopy of vesicle fluid 
B. Immunofluorescence of skin scrapings 
C. Both
D. Neither
A

B

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19
Q 
Method used used routinely for diagnosis of herpes simplex encephalitis
A. Electron microscopy of vesicle fluid 
B. Immunofluorescence of skin scrapings 
C. PCR
D. All 3
A

C

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20
Q

identify CPE of herpes virus

A

typical ballooning of cells

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21
Q 
Acyclovir & Valacyclovir directly inhibit synthesis of \_\_
A. DNA
B. RNA
C. Protein
D. Peplomers
A

A

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22
Q

recurrence of chickenpox is called __

A

Shingles

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23
Q

How does VZV enter the body? Where does it go after?

A

respiratory system then lymphoid tissue

24
Q

Latency of VSV is in __

A

cerebral of posterior root ganglia

25
Q
  • Incubation period: 14-21 days
  • self-limiting
  • Fever, lymphadenopathy, widespread of vesicular rash

identify the VSV clinical manif

A

varicella

26
Q

false about Shingles
A. Mainly affect a single dermatome of the skin
B. Any age but mostly in patients more than 50 year old
C. Latent virus reactivates in a motor ganglion and tracks
motor the sensory nerve to the appropriate segment
D. Characteristic eruption of vesicles in the dermatome;
often accompanied by intensive pain which may last for
months

A

C

sensory, not motor

27
Q

In serology, presence of __ confirms past infection and immunity

A

VZV IgG

28
Q

in serology, presence of __ confirms recent primary infection

A

IgM

29
Q

What is used to prevent development of the illness in patients exposed to varicella?

A

ϒ-globulin of high varicella-zoster virus antibody titer

30
Q 
false about Acyclovir in VSV treatment
A. Prevent development of systemic disease in varicellainfected
immunosuppressed patients
B. Halt progression of zoster in adults
C. Prevents postherpic neuralgia
A

C

31
Q 
Vaccine of VSV is \_\_
A. live attenuated
B. conjugated
C. killed
D. pure polysaccharide
A

A

32
Q

Reactivation of CMV can lead to vertical transmission. T or F?

A

T

33
Q 
Which is not a way to transmit CMV?
A.sexual
B.perinatal
C.postnatal
D.arthropod-borne
A

D

34
Q

Congenital infection of CMV may result in __

A

cytomegalic inclusion disease

35
Q

False about Congenital CMV
A)2nd most common cause of mental handicap after
Down’s syndrome
B) Transmission to the fetus may occur following primary
or recurrent CMV infection (40% chance)
C) May be transmitted to the fetus during primary stage of pregnancy only
D) No evidence of teratogenicity

A

C

all stages possible

36
Q

For CMV, __ is regarded as gold standard but requires up to 4 weeks for result

A

Conventional cell culture

37
Q 
Which body fluids manifest (+) for neonates with CMV?
A. urine and saliva
B. blood and saliva
C. urine and blood
D. urine,blood and saliva
A

A

38
Q 
Which body fluids manifest (+) for adults with CMV?
A. urine and saliva
B. blood and saliva
C. urine and blood
D. urine,blood and saliva
A

C

39
Q 
Which body fluids manifest (+) for pregnant women with CMV?
A. urine and saliva
B. blood and saliva
C. urine and blood
D. none of the 3
A

D

serology only: igM and igG

40
Q

diagnostic test routinely used for the
rapid diagnosis of CMV infection in
immunocompromised patients

A

pp65 CMV antigenaemia test

41
Q

in detecting CMV, DEAFF test can provide a result in 24-48 hours. what does DEAFF mean?

A

(Detection of Early Antigen Fluorescent

Foci)

42
Q

Pure polysaccharide vaccine is available in CMV prevention. T or F

A

F

no vaccine available

43
Q

False about Epstein-Barr virus
A.Membrane is derived by budding of immature particles
through cell membrane and is required for infectivity
B.Viral genome integrates into the cellular DNA
C.Viral genome forms circular episomes which reside in the nucleus
D.All are false.

A

B

44
Q

Epstein-Barr virus cannot be transmitted through kissing. True or False?

A

False

45
Q

False about EBV pathogenesis
A. Once infected, a lifelong carrier state ensues.
B. EBV is able to immortalize T-lymphocytes in vitro and in
vivo
C. EBV is associated with several very different diseases
where it may act directly or one of several co-factors
D. The disease is kept at bay by immune defenses.

A

B

B-lymphocytes dapat

46
Q 
Epstein-Barr virus is associated with the ff except
A. infectious mononucleosis
B. Burkitt's lymphoma
C. genital warts
D. nasopharyngeal carcinoma
A

C

47
Q

False about EBV infectious mononucleosis
A. Usually self-limited
B. consists of fever, lymphadenopathy, and splenomegaly
C. Diagnosis of IM – heterophil antibody test, detection of
EBV IgG
D. No specific treatment

A

C

IgM, not IgG

48
Q

False about Burkitt’s lymphoma
A.Does not respond favorably to chemotherapy
B.Multiple copies of EBV genome and some EBV antigens
are found in BL cells
C.Patients with BV have high titers of antibodies against
various EBV antigens

A

A

49
Q

False about nasopharygeal carcinoma
A.Malignant tumor of the ciliated columnar epithelium of the
nasopharynx
B.There is a number of environmental and genetic cofactors
C.Usually presents late and thus prognosis is poor

A

A

squamous

50
Q

occurs exclusively in males who inherited a defective gene in the X-chromosome (XY chromosome for men); accounts for half of the fatal cases of EBV IM

A

Ducan X-linked lymphoproliferative syndrome

51
Q

False about diagnosis of Burkitt’s lymphoma
A.Tumor can be stained with antigens to lambda light
chains
B.Reveals a monoclonal tumor of B-cell origin
C.Cells express IgM at the cell surface
D.None of the above

A

A

antibodies dapat

52
Q

False about EBV vaccination
A.Vaccine against EBV prevents primary EBV infection;
should be able to control BL and NPC
B. Must be given early in life
C. Useful in seronegative organ transplant recipients & those
developing severe IM
D. Vaccine should preferably be a live vaccine

A

D

subunit vaccine dapat; live vaccine - tumorigenic

53
Q

main target of HHV6 and HHV7
A. NK cell
B. B cell
C. T cell

A

C

54
Q

Which is false?
A. HHV-6 & HHV-7 infection are acquired rapidly after when the effect of maternal antibody wears off
B. HHV-6 & HHV-7 remain latent in the body after primary
infection and reactivates from time to time
C. HHV-6/HHV-7 are transmitted sexually

A

C

Transmitted mainly through contact with saliva and breastfeeding

55
Q

Identify the HHV6 clinical manifestation

o Most cases occur in infants 4 months old – 2 years
o Spiking fever over a period of 2 days followed by a mild
rash; fever is high enough to cause febrile convulsions

A

Roseola Infantum

56
Q

main diagnostic method for HHV-6 & HHV-7

A

Serology

57
Q

HHV-8 DNA is found in almost 100% of __cases

A

Kaposi’s sarcoma

KS

PH 152 (47 decks)

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