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Flashcards in Enteric Viruses Deck (46):
1

Rotavirus is a Reovirus. What does REO mean?

REOVirus : - Respiratory Enteric Orphan Virus

2

genome of Reovirus

double stranded RNA

3

False about Reovirus virion
A.Two concentric helical capsid with capsomeres
B. contains several enzymes for transcription
and capping of viral RNA
C. both

A

icosahedral dapat

4

False about Reovirus
A. no envelope
B. replication is at nucleus & virions not completely coated
C. stable to heat, 3-9pH & lipid solvents
D. inactivated by 95% ethanol, phenol, chlorine

B

cytoplasm dapat

5

Reovirus is stable in all except
A)heat
B)95% ethanol
C)3-9 pH
D)lipid solvents

B

6

Rotavirus group __ : primary human pathogens
(A, B, C, D)

A

7

For Rotavirus: outer capsid proteins used for serotyping

VP4, VP7

8

protein in intermediate capsid (rota virus)

VP6

9

protein in inner capsid (rotavirus)

VP2

10

Mature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

A

11

Immature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

B

12

viral protein in Rotavirus for binding & defining P serotype

VP4

13

viral protein in Rotavirus for defining G serotype

VP7

14

Rotavirus attaches via VP4 to what host cell receptor?

sialic acid

15

in rotavirus
what cleaves VP4 to VP8 and VP5?

Trypsin enzyme

16

reduction in __ of outercapsid leads to removal of VP7. releasing double shelled virus

Ca

17

What do VP1 and VP3 facilitate? for rotavirus
A. significant parts of central dogma
B. attachment
C. virus assembly

A

transcription, translation, protein syn

18

Rotavirus lyses the cell. T or F?

T

19

Most common G serotype all over the world for rotavirus

G1

20

Most common G serotype in country for rotavirus

G3

21

viral enterotoxin c/o rotavirus that induces diarrhea

non-structural protein 4

22

which parts of GIT are most affected by rotavirus?

proximal duodenum to proximal jejunum

23

which is false?
A. rotavirus only takes small inoculum to develop disease
B. rotavirus affects gastric and colonic mucosa
C. rotavirus may also cause lack of sugar degradation
D. more common during cold months

B

24

clinical triad of rotavirus

fever, vomiting, diarrhea

25

rotavirus has respiratory symptoms, t or f?

t

REOvirus!! symptoms: cough, coryza

26

most sensitive method of diagnosis for rotavirus

PCR

27

Rotavirus can be cultured in media with __

trypsin

28

vaccine for rotavirus is
A.combination
B.pure polysaccharide
C.live attenuated

C

given orally, too :)

29

official name of norovirus

norwalk-like viruses

30

family of norovirus

Caliciviridae

31

false about norovirus
A. 6 =number of genogroups @ norovirus
B. genome is (+)ssRNA
C. virion is icosahedral
D. enveloped virus

D

naked say

32

defining char of norovirus surface

cup like depression

33

non-structural protein from RNA involved in RNA transcription

VPg

34

norovirus affects what part of GIT?

Proximal duodenum
proximal jejunum

35

enumerate what is/are malabsorbed due to norovirus

fat, lactose and D-xylose

36

most common clinical manifestation of norovirus

stomach flu

37

Once you have been infected with Norovirus, you are forever immune. true or false?

false;no lifelong immunity

38

most widely used technique to detect Caliciviruses

PCR

39

Vaccine is available for people who wish to not get Norovirus. T or F?

F

40

Genus of Astrovirus

Mamastovirus

41

false about Astrovirus
A. icosahedral virion
B. single strand negative sense RNA
C. no envelope
D. stable in acid and resistant to heat

B

positive!!

42

most important capsid proteins of astrovirus

VP26 and VP29

43

symptomatic duration for astrovirus

3-4 days

44

most useful way of diagnosing astrovirus

electron microscopy

45

A. orofecal transmission
B. highest infection rates in summer months
C. low infective dose
D. symptomatic treatment

False about astrovirus

B

rainy dapat

46

body's mechanism of immunity vs rotavirus

local intestinal IgA