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Flashcards in Systemic Mycoses Deck (40):
1

Etiologic agents of systemic mycoses are ___ fungi
A. unimorphic
B. dimorphic
C. multimorphic

B

2

reproductive pattern of molds

sporulation

3

possible causative agents of Valley Fever

Coccidioides immitis and Coccidioides posadasii

4

gross morphology of Coccidioides at Saboraud's Dextrose Agar

White to tan cotton colony

5

microscopic morphology of Coccidioides at Lactophenol Cotton Blue

thick walled barrel shaped arthrospores

6

microscopic morphology of Coccidioides @ Gomori’s methanamine silver

spherules with
endospores (pathognomonic of coccidioidomycosis)

7

A.Thrives in Dry Soil w/ High carbon and salt content
B.Semi-Arid Relatively Hot Regions
C.Seen in the Philippines

False about Coccidioides

C

8

Pathogenesis of Coccidioides
digging of soil --> aerosol of arthrospores --> inhaled --> become (A) --> (A) produces (B) --> (B) released in lungs

What are (A) and (B), respectively?

(A)spherules
(B)endospores

9

victims of Coccidioides are either asymptomatic or with __ infection at primary stage
A. cardiac
B. pulmonary
C. gastrointestinal
D. cutaneous

B

10

For pulmonary coccidiomycosis, what is the best specimen to collect?

Sputum

11

microscopic morphology of Coccidioides at KOH/Calcofluor white

spherules with endospores

12

Skin test can be used to diagnose Coccidiomycosis. T or F?

T. exact positive result: redness and swelling

13

Ohio Valley Fever
Darling’s Disease
Reticuloendotheliosis
Cave Disease

These all refer to ___

Histoplasmosis

14

main difference in mycelial & yeast colonies of Histoplasma

mycelial: cottony
yeast: waxy

15

Histoplasma capsulatum , which is of ___ shape, usually inhabits these cells.

fish-eye
alveolar macrophages

16

habitat of Histoplasma capsulatum

Moist soil due to high nitrogen content supplemented
with bird/bat guano

17

infective stage of Histoplasma capsulatum

microconidia

18

Primary Acute Pulmonary Disease of Histoplasma produces a lesion quite similar to ___ of primary TB

Ghon's complex

19

hematogenous spread of Histoplasma produces a lesion quite similar to ___ of progressive TB

Miliary TB

20

lesions present in African Histoplasmosis: enumerate

Mucocutaneous lesions (abscess formation and
ulceration)
Insidious osteolytic lesions in ribs, long bones, and
cranium

21

microscopic exam of Histoplasmosis

Broadly attached buds on thick walled yeast cells: broad
base

22

Differentiate Coccidioides fr Histoplasma, in terms of culture.

Histoplasma uses Glucose-Cysteine Blood Agar
Coccidioides uses Blood Agar Slants

23

Gilchrist’s disease
Chicago Disease

also known as __

Blastomycosis

24

etiologic agent of Blastomycosis

Blastomyces dermatitidis

25

Blastomyces microscopic morphology @ LPCB

lollipop (very tiny conidia)

26

Blastomyces microscopic morphology @ Gomori's methanamine silver stain

thick walled,
multinucleated, spherical yeast

27

A. Dormant: warm, dry season
B. Growth and sporulation: cold, wet season
C. Dwells in soil with low organic matter

Which is false about Blastomyces?

C

high dapat

28

When airborne Blastomyces spores are inhaled by a human, s/he can have what lesions?

granulomatous, suppurated lesions

29

clin manif of Cutaneous Blastomycosis

painless, raised, verrucous lesions

30

microscopic exam of Blastomyces will show

Broadly attached buds on thick walled yeast cells: broad
base

31

Which is not a valid source of Blastomyces?
A.Sputum
B.Pus
C.Exudates
D.Feces

D

32

Serologic tests used to diagnose most, if not all, systemic mycoses - enumerate

Immunodiffusion
Complement Fixation Test

33

South American Blastomycosis is also known as ___ / ___

Paracoccidioides
Paracoccidioidal Granuloma

34

Etiologic agent of South American Blastomycosis

Paracoccidiodes brasilienses

35

microscopic exam of Paracoccidioides brasilienses in Methenamine silver stain

appears like a Mariner’s steering wheel

36

P.brasilienses prefers cool, humid soil. ___ therefore have occupational risk in acquiring it.
A. Agricultural Workers
B. Nurses
C. Fishermen
D. All of the above

A

37

There is no latency period for primary pulmonary infection of P.brasilienses;
granulomatous lesions manifest immediately.

T or F?

F


Long latency period: may last for 10-20 years

38

mucocutaneous clinical manifestation of Paracoccidioides brasilienses

Painful ulcerated lesion may appear on the tongue,
gums, or palate

39

culture media used in diagnosis of P.brasilienses that is not usually used for diagnosis of Coccidioides, Histoplasma and Blastomycoses

Yeast Extract Agar

40

Systemic mycoses are contagious. T or F?

F

not contagious