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Flashcards in Borrelia Deck (25):
1

endemic relapsing fever is caused by?

Borrelia recurrentis

2

vector of endemic relapsing fever

genus Ornithodorus (ticks)

3

False abt Borrelia recurrentis
A. can be cultured in fluid media
B. slow multip in chick embryos
C. passed from gen to gen in some ticks
D. stain readily with bacteriological dyes

B

rapid dapat

4

false about antigenic structure of B.recurrentis
A. remain the same throughout course of single infection
B. permit survival of only antigenically distinct variants
C. act as selective factor
D. none of the 3

A

pabago-bago throughout

5

Which is not a fatal manifestation of the presence of B.recurrentis?
A. hemorrhagic lesions in kidney and GIT
B. spirochetes in liver and spleen
C. over heating of the heart
D. spirochetes in brain and spinal fluid

C

6

Before B.recurrentis enters the bloodstream, what part of the body does it infect?

mucous membrane

7

false about febrile stage of B.recurrentis pathogenesis:
A. organism is absent
B. antibodies vs spirochetes are present
C. attack is terminated by agglutinating and lytic effects
D. relapse may still occur

A

organism is present; sa afebrile stage siya wala.

8

in thick/thin blood smears, what smear is used?
A. Wright
B. Giemsa
C. both A& B
D. none of the choices

C

9

Animal inoculation (white mice): used for diagnosis of relapsing fever. How is the bacteria inoculated?

intraperitoneally

10

Which is not a way for a tick to transmit B.recurrentis?
A. biting
B. being crushed
C. both are ways
D. both are not ways

C

11

infected humans with lice --> lice becomes infected by ___

sucking blood

12

Vaccination is a method commonly used to prevent relapsing fever. T or F

F
no vaccine is available

13

What disease is caused by Borrelia bugdorferi?

lyme disease

14

Lyme disease's causative agent is transmitted by bite of a small __ tick

Ixodes

15

T or F: B.burgdorferi stains readily with acid dye but not with aniline dye

F

it can readily be stained by both dyes

16

What structure makes B.burgdorferi highly motile?

endoflagella

17

complex liquid medium used to culture B.burgdorferi

Barbour-Stoenner-Kelly medium

18

What helps B.burgdorferi live in very diff ticks and mammalian hosts?

large number of sequences of lipoproteins

19

In the course of pathogenesis, B.burgdorferi adheres to ___ on host cells. c/o ___

proteoglycans
borrelial GAG receptor

20

In what stage does erythema chronicum migrans happen?
A. stage 1
B. stage 2
C. stage 3
D. all 3 stages

A

21

Which is false about B.burgdorferi diagnosis?
A. blood is used for seroloical tests
B. CSF is the best sample
C. culture takes 6-8 weeks
D. molecular probes(PCR) have 85% sensitivity, but lower sensitivity @ synovial fluid samples

B

22

Western blot is a technique used to confirm results by other tests. It usually utilizes the ____ with the bacteria's proteins

size of the antibody reactions

23

In electrophoresis, the antigens of B.burgdorferi are separated and transferred to a ___ + reacted with patient serum

nitrocellulose membrane

24

Which is false?
A. immunologic response develops slowly
B. early antimicrobial treatment increases antibody response
C. both are true
D. both are false

B

Decreases dapat

25

Which is false?
A. nymphal stage is where least exposures occur, since ticks are least active. May-July
B. larval stage: Aug to Sept
C. adult stage: feed on humans, transmit B.burgdorferi, spring to fall

A

change least to most