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Flashcards in Life Cycles Path Deck (128)
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1

What is the premalignant lesion for Cervical Squamous Cell Carcinoma?

Cervical Intraepithelial Neoplasia (CIN)

2

Female - vulvar skin is pale gray and parchment-like

Lichen Sclerosus/Chronic Atrophic Vulvulitis

3

What is the premalignant lesion for Vulular Carcinoma?

Vulvular Intraepithelial Neoplasia (VIN)

4

What is the premalignant lesion for Squamous Cell Carcinoma of the Vagina?

Vaginal Intraepithelial Neoplasia (VAIN)

5

Location of Squamous Cell Carcinoma of the Vagina?

Upper posterior vagina

6

Location of Clear Cell Adenocarcinoma of the Vagina?

Upper anterior vagina

7

What is the premalignant lesion for Clear Cell Adenocarcinoma of the Vagina?

Atypical vaginal adenosis

8

Amenorrhea definition

Absence of bleeding for at least 3 cycles

9

Oligomenorrhea definition

Bleeding that occurs at an interval of >35 days

10

Polymenorrhea definition

Bleeding that occurs at an interval of

11

Menorrhagia definition

Excessive, prolonged, heavy bleeding

12

Metorrhagia definition

Bleeding at irregular intervals

13

Menometorrhagia definition

Heavy bleeding at irregular intervals

14

Dysmenorrhea

Painful menstruation with abdominal cramps

15

Difference between ectopic endometrium and eutopic endometrium?

Ectopic has aromatase P450 enzyme.
Eutopic does not have that enzyme.

16

What is the premalignant lesion for Endometrial Adenocarcinoma?

Endometrial Intraepithlial Neoplasm (EIN)/ Complex endometrial hyperplasia with atypia

17

Adenocarcinoma of the Fallopian Tube mutation?

p53 mutation -> dysplaisa

18

Invasive Ductal Carcinoma mets locally and distant

local = axillary LN
distant = lung, brain

19

Invasive Lobular Carcinoma mets locally and distant

local = axillary LN
distant = bone, GI, uterus, ovary, serosa

20

Origin of ovarian epithelial tumors?

Fallopian tube fimbrae

21

Endodermal sinus/Yolk sac tumors (female and male) stain for?

Alpha-fetoprotein positive (AFP +)

22

Which ovarian tumors are hormonally active?

Sex cord stromal tumors

23

Area of the prostate involved in BPH?

transitional zone, periurethral

24

Area of the prostate involved in prostatic neoplasms?

peripheral zone

25

What is the premalignant lesion for Prostate Adenocarcinoma?

Prostatic Intraepithelial Neoplasia (PIN) - still has outer basal cell layer

26

Prostate Adenocarcinoma mets - local and distant

local = early - obturator; late - para-aortic
distant = bone, brain, lungs

27

Bell Clapper Deformity?

cause of testicular torsion in adolescents. lack of posterior attachment of the scrotum and testicle due to tunica vaginalis wrapping all the way around the testicle.

28

Male germ cell tumor mutation

Isochromosome of Chr 12 - loss of long arm with duplication of the short arm

29

Characteristics of Seminomatous type germ cell tumors in males (5)

-older patients
-low tumor marker expression
-late mets
-met via lymphatics
-radiosensitive

30

Characteristics of Non-seminomatous type germ cell tumors in males (5)

-younger patients
-elevated tumor marker expression
-early met
-met via hematogenous and lymphatics
-radioresistant