Flashcards in Life Cycles Path Deck (128)
What is the premalignant lesion for Cervical Squamous Cell Carcinoma?
Cervical Intraepithelial Neoplasia (CIN)
Female - vulvar skin is pale gray and parchment-like
Lichen Sclerosus/Chronic Atrophic Vulvulitis
What is the premalignant lesion for Vulular Carcinoma?
Vulvular Intraepithelial Neoplasia (VIN)
What is the premalignant lesion for Squamous Cell Carcinoma of the Vagina?
Vaginal Intraepithelial Neoplasia (VAIN)
Location of Squamous Cell Carcinoma of the Vagina?
Upper posterior vagina
Location of Clear Cell Adenocarcinoma of the Vagina?
Upper anterior vagina
What is the premalignant lesion for Clear Cell Adenocarcinoma of the Vagina?
Atypical vaginal adenosis
Absence of bleeding for at least 3 cycles
Bleeding that occurs at an interval of >35 days
Bleeding that occurs at an interval of
Excessive, prolonged, heavy bleeding
Bleeding at irregular intervals
Heavy bleeding at irregular intervals
Painful menstruation with abdominal cramps
Difference between ectopic endometrium and eutopic endometrium?
Ectopic has aromatase P450 enzyme.
Eutopic does not have that enzyme.
What is the premalignant lesion for Endometrial Adenocarcinoma?
Endometrial Intraepithlial Neoplasm (EIN)/ Complex endometrial hyperplasia with atypia
Adenocarcinoma of the Fallopian Tube mutation?
p53 mutation -> dysplaisa
Invasive Ductal Carcinoma mets locally and distant
local = axillary LN
distant = lung, brain
Invasive Lobular Carcinoma mets locally and distant
local = axillary LN
distant = bone, GI, uterus, ovary, serosa
Origin of ovarian epithelial tumors?
Fallopian tube fimbrae
Endodermal sinus/Yolk sac tumors (female and male) stain for?
Alpha-fetoprotein positive (AFP +)
Which ovarian tumors are hormonally active?
Sex cord stromal tumors
Area of the prostate involved in BPH?
transitional zone, periurethral
Area of the prostate involved in prostatic neoplasms?
What is the premalignant lesion for Prostate Adenocarcinoma?
Prostatic Intraepithelial Neoplasia (PIN) - still has outer basal cell layer
Prostate Adenocarcinoma mets - local and distant
local = early - obturator; late - para-aortic
distant = bone, brain, lungs
Bell Clapper Deformity?
cause of testicular torsion in adolescents. lack of posterior attachment of the scrotum and testicle due to tunica vaginalis wrapping all the way around the testicle.
Male germ cell tumor mutation
Isochromosome of Chr 12 - loss of long arm with duplication of the short arm
Characteristics of Seminomatous type germ cell tumors in males (5)
-low tumor marker expression
-met via lymphatics