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Flashcards in Lipids III Deck (41):
1

what is different about membrane lipiids

they carry electral charges

2

what is the rate limiting step of the synthesis of PC

rphosphocholine transferred to CTP by phosphocholine cytidyltransferase

3

how is PE syntheised

ethanolamine activated, transferred to CTP
transfer ethanolamine to diacylglyceral

4

what is PS made by

phosphatidyl serine synthase - changes polar head froup on PE with serine

5

what is unique about the synthesis of PI

the dicylglycerol (not the head group) is activated by binding to CTP.

6

cardiolipin

biologically important lipid of inner mitochondrial membrane

7

structure of cardiolipin

phospholipid dimer where 2 phosphatidic acid molecules are connected bia glycerol bridge

8

function of cardiolipin

helps with foldign of mitochondrial electron transport compoexes,
buffers electrons in membranes

9

when do you see cardiolipin insufficiency

normal ageing but also alzheimers and parkinsons

10

outer leaflet contains waht

choline containing lipids PC and sphingomylen

11

inner leaflet contains waht

PE and negatively charged lipid like PS

12

how is arachidonic acid introduced into phospholipids

exchange of FAs bia phospholipases

13

characteristics of freashly synthesized phospholipds

saturated FA or oleic acid in C1
unsaturated FA in C2

14

phospholipise C reaction

phospholipase C ---> IP3 + DAG

15

unpon stimulation what does phospholipiase A2 do

cleave arachidonic acid from the C2 of phospholipids

16

general function of phospholipiase A2

prodcues signalling molcules of prostaglandin and thromboxane classes.

17

what does arachidonic acid need to be synthesized from

linoleic acid (essential FA)

18

how is free arachidonic acid converted into PGH2

substrate for CO/PGH synthase complex

19

PGH2

precursor for wide viarety of signaling lipids

20

functions of PGs

vasoluation during inflammation
stimulate contractiosn of uterus
inhibit platelet aggrestion

21

where can prostaglandin synthesis be inhibited

level of phospholipiase A2 by corticosteroids
levle of COX1/2 and prostagland synthsie by NSAIDS

22

leukotrienes

family of bioactive liipds that function as messengers and hormones

23

how are leukotriens synthesized

from arachidonic acid follwoign stimulation of phospholipiase A

24

what is leukotriene syntheiss initated by

lipoxygenase reaction

25

what is the half life of keukotrines

4 hours

26

function of LTC4 and LTD4

smooth muscle contraction

27

how can you treat asthma

lipoxygenase inhibitors which slow production of leukotrines

28

plasmalogens

special category of membrane lipids that contain fatty alcohol in ether linkage

29

what parts of the body are rich in plasmalogens

immune system
brain heart

30

what is plasmalogen deficieny assocaited with

alzheimers and down syndrome

31

what is the critical step of plasmalogen syntehsis

induction of ether linkage

32

where does the critical step of plasmoglen synthesis take place

peroxiaomes

33

what do patients with zellweger have

plasmalogen defiency

34

what are sphingolipids derived from

teh alcholo spingosine

35

do sphingolipids contain glyceral

no

36

what is the lipid component of spingomyelin

ceramide

37

transfer of phosphocholine to ceramide leads to

spingomylein

38

transfer of glucose or galactose on cereamide leads to

cerbrosides

39

transfer of sulfate group to cerebrosides yeilds

sulfatide

40

transfer of 2-4 neutral sugars to ceramid lead to

globosides

41

transfer of several sugars to ceramide

gangliosides