Structure of proteins III Flashcards Preview

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Flashcards in Structure of proteins III Deck (26):
1

What affect do carbamates have on Hb

stabilize T state, promote O2 release

2

what happens when you reduce pH

promote O2 relase

3

what is the most common form of hemoglobin in adults

alpha2beta2 hemoglobin

4

what other type of Hb does adult blood contain

alpha2delta2

5

what is the predominate form of Hb in fetus during second and third trimester

alpha2gamma2

6

what is unique about HbF

histidine residency is replaced by serine, has incrased oxygen affinity

7

what is Hbsaki/Hbgenova

proline is introduced into an alpha-helical section

8

what is Hbcowtown

amino acid substituion destrabilizes the T form of molecule

9

methemoglobin

Fe2+ is oxidized to Fe3+

10

what substituion takes place in sickle cell

glutamate by valine

11

protein domain

substructure produced by any part of a polypeptide chain that can fold independently into a compact, stable structure

12

what are individual domains often connected by

flexible linkkers

13

what is collagen made up of

glycine
alanine
proline
hydroxyproline

14

what are the most abundant proteins in the body

collagen

15

what is collagen

glycoproteins of CT

16

what is the structure of collagen

triple helical units

17

how does the collagen helix twist

twists to the left, one turn every 3 residues

18

what is the repeating sequency of colalgen

gly - proline - hydroxyproline

19

where are glycine residues in tropocollagen

in the center, allowing a tight fit

20

how is the triple helix stabilized

interchain hydrogen bonds

21

how is hydroxyproline residues important in collagen

form additional hydrogen bonds, vital for stability

22

formation of hydroxyproline an dhydroxylysine requires what

Fe2+. ascorbate, and alpha ketoglutarate

23

what catalyzes the formation of hydroxyproline

prolyl hydroxylase

24

what is happening in scury

lack of ascorbate precents formation of hydroproline and hydrozylysine, so collagen can't form stable helcies and CT is all fucked up

25

symptoms of scurby

leg pain, irritability, dry skin, bruising

26

osteogenesis imperfecta

brittle bone diseases
can be lethal, or the pt can barely notice it