Protein and Amino Acid Metabolism V Flashcards
(36 cards)
what do you need for the synthesis of cretine
glycine, arginine, SAM
when is the phosphorylation of creatine favored
when ATP conc in muscle is high
is the phophate group transfer potential of creatine phosphater higher or lower than that of ATP
higher
what happens allows for continued muscle contraction during an intense burst o faerobic activity
regen of ATP from creatine phospahte and ADP
what releases creatinine
muscel cells
how is creatinine excreted
urine
amount of creatinine excreted each day is propertion to waht
muscle mass
creatinine is an indicator of what
kidney function
symptoms of children suffering from defect of enzyme of creatine synthesis/uptake
hypotonia, neurlogical symtoms
little skeletal/cardiac muscle pathology
how do you treat children with creatine synthesis problem
dietary supplementation of creatine
what catecholamine signaling molcules are derived from tyroosine
dopamine
norepinephrine
epinephrine
how do you get from tyrosin to epinephrine
tyrosine –> DOPA —> dopamine —> NE —-> epinerphee
what are tyrosines contained in
thryoglubulin
what is thyrglobin degreated in
lysosomes
where does synthesis of melanin take place
melanocytes
how do you get synthesis melanin
tyrosine —-> DOPA —–> dopaquinone —–>melanin
what is required for the conversion of NO to epinephrine
SAM
what casues oculocuaneous albinism type 1
loss of function of tyrosinase due to mutation in TYR gene
what is serotonin derived from
tryptophan
where is serotonin most abudant
platelets and GI tract
where is serotonin produced
pineal gland
what does the melatonin synthesis reaction require
SAM
what does tryptophan convert to by the liver
niacin
what converts tryptophan to niacin
IDO
