Flashcards in Lymph Nodes Deck (343)
Kaposi's sarcoma vs. vascular transformation of lymph node (2).
Vascular transformation of lymph node:
- Sparing of capsule.
- No hyaline globules.
Extramedullary hematopoiesis: Locations in the lymph node (2).
Extramedullary hematopoiesis: Immunohistochemical markers of megakaryocytes (2).
Myeloid sarcoma: Clinical settings (4).
Established diagnosis of AML.
Harbinger of AML.
Sign of impending blast crisis in CML.
Sign of leukemic transformation of MDS.
Extramedullary hematopoiesis: Sites (4).
Bones (lytic lesions).
Extramedullary hematopoiesis: Histology.
Sheets of myeloblasts with or without maturation.
Myeloid sarcoma: Aberrantly expressed antigens.
CD43, CD4, or CD7 may be expressed.
Myeloid sarcoma: Clue to diagnosis.
High-grade neoplasm in the lymph node that does not express CD3, CD20, CD138, or cytokeratin.
Mast-cell disease: Location in the lymph node.
May involve any compartment, but especially the paracortex.
Mast-cell disease: Histology (3).
Sheets or small clusters of mast cells.
Eosinophils (sometime enough to obscure the infiltrate).
Mast-cell disease: Aberrantly expressed markers (3).
CD2, CD25, CD30.
Mast-cell disease: Mutation.
Activating point mutation in codon 816 of KIT.