Flashcards in Lymph Nodes Deck (343)
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331
Kaposi's sarcoma vs. vascular transformation of lymph node (2).
Vascular transformation of lymph node:
- Sparing of capsule.
- No hyaline globules.
332
Extramedullary hematopoiesis: Locations in the lymph node (2).
Paracortex.
Sinuses.
333
Extramedullary hematopoiesis: Immunohistochemical markers of megakaryocytes (2).
CD42b, CD61.
334
Myeloid sarcoma: Clinical settings (4).
Established diagnosis of AML.
Harbinger of AML.
Sign of impending blast crisis in CML.
Sign of leukemic transformation of MDS.
335
Extramedullary hematopoiesis: Sites (4).
Soft tissues.
Lymph nodes.
Skin.
Bones (lytic lesions).
336
Extramedullary hematopoiesis: Histology.
Sheets of myeloblasts with or without maturation.
337
Myeloid sarcoma: Aberrantly expressed antigens.
CD43, CD4, or CD7 may be expressed.
338
Myeloid sarcoma: Clue to diagnosis.
High-grade neoplasm in the lymph node that does not express CD3, CD20, CD138, or cytokeratin.
339
Mast-cell disease: Location in the lymph node.
May involve any compartment, but especially the paracortex.
340
Mast-cell disease: Histology (3).
Sheets or small clusters of mast cells.
Fibrosis.
Eosinophils (sometime enough to obscure the infiltrate).
341
Mast-cell disease: Aberrantly expressed markers (3).
CD2, CD25, CD30.
342
Mast-cell disease: Mutation.
Activating point mutation in codon 816 of KIT.
343
