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Flashcards in Lymph Nodes Deck (343)
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331

Kaposi's sarcoma vs. vascular transformation of lymph node (2).

Vascular transformation of lymph node:

- Sparing of capsule.
- No hyaline globules.

332

Extramedullary hematopoiesis: Locations in the lymph node (2).

Paracortex.

Sinuses.

333

Extramedullary hematopoiesis: Immunohistochemical markers of megakaryocytes (2).

CD42b, CD61.

334

Myeloid sarcoma: Clinical settings (4).

Established diagnosis of AML.

Harbinger of AML.

Sign of impending blast crisis in CML.

Sign of leukemic transformation of MDS.

335

Extramedullary hematopoiesis: Sites (4).

Soft tissues.

Lymph nodes.

Skin.

Bones (lytic lesions).

336

Extramedullary hematopoiesis: Histology.

Sheets of myeloblasts with or without maturation.

337

Myeloid sarcoma: Aberrantly expressed antigens.

CD43, CD4, or CD7 may be expressed.

338

Myeloid sarcoma: Clue to diagnosis.

High-grade neoplasm in the lymph node that does not express CD3, CD20, CD138, or cytokeratin.

339

Mast-cell disease: Location in the lymph node.

May involve any compartment, but especially the paracortex.

340

Mast-cell disease: Histology (3).

Sheets or small clusters of mast cells.

Fibrosis.

Eosinophils (sometime enough to obscure the infiltrate).

341

Mast-cell disease: Aberrantly expressed markers (3).

CD2, CD25, CD30.

342

Mast-cell disease: Mutation.

Activating point mutation in codon 816 of KIT.

343

Mast-cell disease: Appearance in lymph node on routine stain.

Because their granules are inconspicuous without special stains, mast cells may be confused with

- Fibrotic foci.
- Histiocytes.
- Lymphoid follicles.