Malabsorption and Small Intestinal Disease Flashcards Preview

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Flashcards in Malabsorption and Small Intestinal Disease Deck (15):
1

What would pain after a fatty meal suggest?

Gallbladder problems

2

What effects gut length?

Size
Gender

3

Why does the gut breakdown food slowly?

Prevents vast osmotic shift

4

What are the symptoms of malabsorption?

Weight loss
Increased appetite
Steatorrhoea

5

What are the clinical signs of malabsorption?

Deficiencies:
Iron
B12, folate
Ca2+, Mg2+
Vitamin D,A

6

What is dermatitis herpetiformis?

Cutaneous manifestation od coeliac disease. Causes blistering, itching

7

What causes dermatitis herpetiformis?

IgA deposits in the skin

8

What tests are used to investigate the small bowel?

Small bowel biopsy
Small bowel study (barium meal)
CT
MRI/ capsule enterography
White cell scan
Bacterial overgrowth

9

In coeliac disease what is the particular sensitivity to gluten?

The gliadin fraction of gluten

10

Where is gluten found?

Wheat
Rye
Barley

11

What is the pathology of coeliac disease?

Inflammatory response
Villous atrophy
Increased intra-epithelial lymphocytes

12

How do you diagnose coeliac disease?

Distal duodenal biopsy
Serology (anti endomusial IgA, anti tissue transglutaminase)

13

What is the treatment for coeliac disease?

Withdraw gluten

14

What are the complications of coeliac disease?

Refractory coeliac disease
Small bowel lymphoma
Oesophageal carcinoma
Colon cancer
Small bowel adenocarcinoma

15

What are the causes of malabsorption?

Inflammation
Infection (HIV, tropical sprue, giardia lambda)
Whipple's disease
Cystic fibrosis
Iatrogenic
Impaired motility