Neuromuscular Junction Flashcards Preview

Thought, Sense and Movement > Neuromuscular Junction > Flashcards

Flashcards in Neuromuscular Junction Deck (13):
1

Which transmitter do all neuromuscular junctions use?

Acetylcholine

2

Name the enzyme which synthesizes Ach?

Cholineacetyl Transferase

3

Name the protein which incorporates Ach into vesicles?

Vesicle Acetylcholine Transporter (VAchT)

4

Where are the SNARE proteins located?

At the 'Dense bars' (active zones)

5

Name the three SNARE proteins, and which one in found within the vesicle membrane?

Synaptobrevin (inside vesicle membrane)
Syntaxin
SNAP25

6

How many nicotinic receptors are there per motor end-plate?

15-40 x 10^6

7

How many vesicles are released from the alpha motor neurone per input?

60-200

8

How many Ach molecules are present per vesicle?

10,000

9

What is found in the base of the subjunctional folds within the skeletal muscles?

Voltage gated sodium channels

10

Describe Myasthena Gravis?

A degenerative autoimmune disorder which destroys the nictonic receptors

11

Describe Botulinum Toxin?

Protein made of a heavy chain which allows for protein to bind and enter a neurone, and a light chain which destroys the docking proteins

12

Describe Curare?

An alkaloid poison which acts as a Ach competitive antagonist

13

Ach binds to which sub-unit on the nicotinic receptor?

Alpha sub-unit