Flashcards in Neuromuscular Junction Deck (13)
Which transmitter do all neuromuscular junctions use?
Name the enzyme which synthesizes Ach?
Name the protein which incorporates Ach into vesicles?
Vesicle Acetylcholine Transporter (VAchT)
Where are the SNARE proteins located?
At the 'Dense bars' (active zones)
Name the three SNARE proteins, and which one in found within the vesicle membrane?
Synaptobrevin (inside vesicle membrane)
How many nicotinic receptors are there per motor end-plate?
15-40 x 10^6
How many vesicles are released from the alpha motor neurone per input?
How many Ach molecules are present per vesicle?
What is found in the base of the subjunctional folds within the skeletal muscles?
Voltage gated sodium channels
Describe Myasthena Gravis?
A degenerative autoimmune disorder which destroys the nictonic receptors
Describe Botulinum Toxin?
Protein made of a heavy chain which allows for protein to bind and enter a neurone, and a light chain which destroys the docking proteins
An alkaloid poison which acts as a Ach competitive antagonist