Pain Mechanisms Flashcards Preview

Thought, Sense and Movement > Pain Mechanisms > Flashcards

Flashcards in Pain Mechanisms Deck (15):
1

What two types of fibres make up nocioceptors?

A-delta fibres
C-fibres

2

Describe A-delta fibres and what do they respond to?

Myelinated, fast fibres which respond to sharp objects and painful extremities to temperature

3

Describe C-fibres and what do they respond to?

NON-myelinated, slow fibres which present with dull pain and aches, they respond to sharp objects and extremities to temperature and chemicals released from damaged tissue substances

4

Name Rexed's laminae layer 1?

Marginal zone

5

Name Rexed's laminae layers 2/3?

Substantia gelitanosia

6

Name Rexed's laminae layers 4/5?

Nucleus propius

7

A-delta fibres from the periphery synapse with which dorsal horn laminae?

Laminae 1 and 5

8

C-fibres from the periphery synapse with which dorsal horn laminae?

Laminae 1 and 2 - have inter-neurones

9

In peripheral sensitisation what is Allodynia?

Nocioreceptors that have been sensitised to non-noxious stimuli via a decrease in threshold activation

10

In peripheral sensitisation what is Hyperalgesia?

Nnocioreceptors that have been sensitised to noxious stimuli via an increase in responsiveness

11

Name the post-synaptic receptors found in central components?

NMDA
AMPA

12

Which intracellular pathways are activated by the NMDA and AMPA receptors?

PKC
CamKII

13

Which intracellular pathways are activated by PKC and CamKII?

ERK
MAPK

14

Which two fibres co-ordinate the gated theory of pain?

A-alpha (type 1a and 1b)
A-beta (type 2)

15

Which dorsal horn laminae do the A-alpha and A-beta inhibitory neurones synapse onto?

Laminae 3