Pain Mechanisms Flashcards Preview

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Flashcards in Pain Mechanisms Deck (15)
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1
Q

What two types of fibres make up nocioceptors?

A

A-delta fibres

C-fibres

2
Q

Describe A-delta fibres and what do they respond to?

A

Myelinated, fast fibres which respond to sharp objects and painful extremities to temperature

3
Q

Describe C-fibres and what do they respond to?

A

NON-myelinated, slow fibres which present with dull pain and aches, they respond to sharp objects and extremities to temperature and chemicals released from damaged tissue substances

4
Q

Name Rexed’s laminae layer 1?

A

Marginal zone

5
Q

Name Rexed’s laminae layers 2/3?

A

Substantia gelitanosia

6
Q

Name Rexed’s laminae layers 4/5?

A

Nucleus propius

7
Q

A-delta fibres from the periphery synapse with which dorsal horn laminae?

A

Laminae 1 and 5

8
Q

C-fibres from the periphery synapse with which dorsal horn laminae?

A

Laminae 1 and 2 - have inter-neurones

9
Q

In peripheral sensitisation what is Allodynia?

A

Nocioreceptors that have been sensitised to non-noxious stimuli via a decrease in threshold activation

10
Q

In peripheral sensitisation what is Hyperalgesia?

A

Nnocioreceptors that have been sensitised to noxious stimuli via an increase in responsiveness

11
Q

Name the post-synaptic receptors found in central components?

A

NMDA

AMPA

12
Q

Which intracellular pathways are activated by the NMDA and AMPA receptors?

A

PKC

CamKII

13
Q

Which intracellular pathways are activated by PKC and CamKII?

A

ERK

MAPK

14
Q

Which two fibres co-ordinate the gated theory of pain?

A

A-alpha (type 1a and 1b)

A-beta (type 2)

15
Q

Which dorsal horn laminae do the A-alpha and A-beta inhibitory neurones synapse onto?

A

Laminae 3