What two types of fibres make up nocioceptors?
A-delta fibres
C-fibres
Describe A-delta fibres and what do they respond to?
Myelinated, fast fibres which respond to sharp objects and painful extremities to temperature
Describe C-fibres and what do they respond to?
NON-myelinated, slow fibres which present with dull pain and aches, they respond to sharp objects and extremities to temperature and chemicals released from damaged tissue substances
Name Rexed’s laminae layer 1?
Marginal zone
Name Rexed’s laminae layers 2/3?
Substantia gelitanosia
Name Rexed’s laminae layers 4/5?
Nucleus propius
A-delta fibres from the periphery synapse with which dorsal horn laminae?
Laminae 1 and 5
C-fibres from the periphery synapse with which dorsal horn laminae?
Laminae 1 and 2 - have inter-neurones
In peripheral sensitisation what is Allodynia?
Nocioreceptors that have been sensitised to non-noxious stimuli via a decrease in threshold activation
In peripheral sensitisation what is Hyperalgesia?
Nnocioreceptors that have been sensitised to noxious stimuli via an increase in responsiveness
Name the post-synaptic receptors found in central components?
NMDA
AMPA
Which intracellular pathways are activated by the NMDA and AMPA receptors?
PKC
CamKII
Which intracellular pathways are activated by PKC and CamKII?
ERK
MAPK
Which two fibres co-ordinate the gated theory of pain?
A-alpha (type 1a and 1b)
A-beta (type 2)
Which dorsal horn laminae do the A-alpha and A-beta inhibitory neurones synapse onto?
Laminae 3
