What two types of fibres make up nocioceptors?
Describe A-delta fibres and what do they respond to?
Myelinated, fast fibres which respond to sharp objects and painful extremities to temperature
Describe C-fibres and what do they respond to?
NON-myelinated, slow fibres which present with dull pain and aches, they respond to sharp objects and extremities to temperature and chemicals released from damaged tissue substances
Name Rexed’s laminae layer 1?
Name Rexed’s laminae layers 2/3?
Name Rexed’s laminae layers 4/5?
A-delta fibres from the periphery synapse with which dorsal horn laminae?
Laminae 1 and 5
C-fibres from the periphery synapse with which dorsal horn laminae?
Laminae 1 and 2 - have inter-neurones
In peripheral sensitisation what is Allodynia?
Nocioreceptors that have been sensitised to non-noxious stimuli via a decrease in threshold activation
In peripheral sensitisation what is Hyperalgesia?
Nnocioreceptors that have been sensitised to noxious stimuli via an increase in responsiveness
Name the post-synaptic receptors found in central components?
Which intracellular pathways are activated by the NMDA and AMPA receptors?
Which intracellular pathways are activated by PKC and CamKII?
Which two fibres co-ordinate the gated theory of pain?
A-alpha (type 1a and 1b)
A-beta (type 2)
Which dorsal horn laminae do the A-alpha and A-beta inhibitory neurones synapse onto?