Flashcards in Bone Growth and Remodelling Deck (15):
1
Name the four types of bone cells?
Osteoprogenitor cells
Osteoblasts
Osteocytes
Osteoclasts
2
Where are osteoclasts found and what is their function?
Found on sites of bone resorption
Function is to erode and remodel the bone
3
What cells are osteoclasts derived from?
Blood monocytes
4
What regulates osteoclastic activity?
Hormones act on osteocytes which regulate osteoclasts
5
What substances to osteoclasts release?
H+ - acidic environment to solubilise the bone matrix
Cl-
Cathepsin K protease - degrades the protein and collagen
6
What condition arises from ossification deficits?
Osteogenesis imperfecta (short stature, fragile bones)
7
What condition arises from mineralisation defecits?
Osteomalacia (adults)
Ricketts (children)
8
In intermembranous ossification what is the template?
Mesenchymal membranous template
9
What type of bones is formed via intermembranous ossification and give an example?
Flat bones
Skull/clavicle/mandible
10
In endochondral ossification what is the template?
Hyaline cartilage
11
What forms the hyaline cartilage?
Mesenchymal cells
12
Define Wolf's law?
Bone of a healthy person will adapt to loads under which it is placed
13
What is the cause of giganticism and acromegly and what is the difference between the two?
Pituarty gland tumour resulting in exccessive production of growth hormone, difference is giaganticism is in children and acromegly is in adults
14
Name the hormone that stimulates osteoclastic activity?
RANKL
15