Flashcards in Neurotransmitter Receptors Deck (20):
What is substance P associated with?
What inhibits substance P?
Give three facts about glutamate?
Over half the synapses in the brain release it, generates EPSP, too much glutamate is toxic
Give the major amino acid NT?
GABA, glutamate and glycine
What is the criteria required to be a NT?
Synthesised in the neurone, present in presynaptic cells(in a suitable amount available to be released), must be able to act equally as a drug and must be removable
Give the major amine NT?
Dopamine, noradrenaline, adrenaline, histamine and serotonin
What is the major inhibitory NT?
Give three facts about GABA?
Third of the synapses in the brains release it, it generates IPSP, potention of signalling can reduce anxiety and be intoxicating
What is the major excitatory NT?
Give and example of a biogenic amine which is involved in the reward system?
Describe Otto-Lowe's experiment?
Two hearts places in separate beakers in buffered solution connected by a tube. Heart one was stimulated and heart two also shower stimulation
What are the two forms of NT?
Small molecules (amino acids, acetylcholine, ATP and dopamine) and large molecules (peptides, substance P and opiods)
What form of NT lasts and travels furthest?
What are peptide hormones co released with?
Small molecule NT
When are peptide NT released?
Only by high-frequency stimulation
What happens to the synaptic vesicles after the NT is released?
It's taken up into the cell by endocytosis
What three categories are biogenic amines split into?
Catechloamines, indoleamine, imidazoleamine.
What NT are inactivated?
Acetylcholine by cholinesterase and other small molecule NT
What NT are retaken up?
Glutamate and GABA