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Flashcards in Molecular Bioogy of Receptors Deck (12)
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What are three tetrameric ionotropic receptors for glutamate?

AMPA, NMDA and kainate


Describe the structure of a metabotropic receptor?

Monomeric, 7-TM domains, extra cellular for NT binding and intracellular for G-proteins


What inhibits GABAa receptors?

Picrotoxin inhibits by blocking chloride ions and changing the membrane potential to be further from threshold.


How many subunits can ionotropic receptors have?

3,4 or 5


How many helices do the ionotropic receptors have?

4 or 3 with a pore loop


What lines the channel of an ionotropic receptor?

Either the second helice or the pore loop. They control the flow


What the ways can ion channels be opened by?

Chemicals (ligand-gated), voltage, and mechanosensory


Describe the structure of a nicotinic acetylcholine receptor and what is it permeable to?

5 subunits, 4 helices in each. Acetylcholine binds to the alpha subunits. Permeable to sodium and potassium and sometimes calcium


What are the two types of receptors?.

1. Ligand-gated ion channels or ionotropic
2. G-protein coupled receptors or metabotropic.


How do ionotropic receptors work?

Several proteins form a channel when NT binds the channel opens, either cationic or anionic, rapid.


Explain how NMDA receptors work?

At resting potential the channel is blocked by magnesium, it's only active drying high frequency stimulation. Magnesium is exposed post-depolarisation as driving force is removed, glycine is a co-agonists and D-Serine.


How many classes of different G-protein coupled receptors are there?

8- glutamate, GABAb, dopamine, noradrenaline, adrenaline, histamine, serotonin, purines and muscarinic.