Non-Hodkins Lymphomas Flashcards
(15 cards)
Teens and young adults
t(8,14)
EBV
Burkitt Lymphoma
(B cell)
(8, B, and Burkitt all look similar)
BCL2 and BCL6 mutation
Most common type
Diffuse Large B cell Lymphoma
t(14,18) Heavy Ig (14) increased BCL2 (18) Waxing, Waning, Indolent
Follicular (Four-teen is Four-llicular)
B cell
BCL2’s function
Inhibit apoptosis
t(11,14)
Cyclin D1 (11) Heavy Ig (14)
Very aggressive presents late
Mantle cell lymphoma
(B cell)
*Mantle te Mata (kills you)
t(11,18) Associated with: chronic inflammation Sjrogrens Gastritis
Marginal zone
B cell
Aids defining illness
EBV
one ring-enhancing lesion
CNS lymphoma
B cell
HTLV
IVDU
Cutaneous lesion
Lytic Bone –> Hypercalcemia
T-cell lymphoma
(Japan –> Tokyo T- cell lymphoma)
Retro drugs and boning in Tokyo
Skin patches/Plaques
atypical CD4+ T cells (cerebriform nuclei)
intraepidermal neoplastic cell aggregates
Mycosis Fungiodes –> Sezary
Low yield
t(8,14) translocates what to heavy Ig chain (14)
c-myc
Presents with Jaw lesions in African children or mass in the abdomen (US) and associated with EBV
Burkitt
Pautirier microabscess
Mycosis Fungiodes –> Sezary
Biopsy of the spleen reveals reveals a lymph node–like appearance with abnormal germinal centers and stains positively for CD20 and bcl-2. All these features point toward
follicular lymphoma, a type of non-Hodgkin lymphoma (NHL).
Men
Diagnostic features include CD5 positivity and a t(11;14) translocation. This translocation leads to over expression of cyclin D1, a known proto-oncogene.
Mantle cell lymphoma
Burkitt lymphoma is a rare cancer of young adults that is associated with Epstein-Barr virus infection, and patients present with an abdominal mass or jaw lesion. Classic overexpression of ___
c-myc
t(8,14)
Translocation between chromosome 8 and the heavy arm of the Ig gene is highly prevalent
