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STEP 1 > SNS/PSNS effects > Flashcards

SNS/PSNS effects Flashcards

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1
Q

Beta 1 blocker effect on Kidneys

A

↓ Renin

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2
Q

Beta 1 blocker effect on heart (3)

A

↓ HR
↓ Contractility
↓ Oxygen consumption

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3
Q

Beta 2 blocker effect on muscle vasculature

A

Vasospasm

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4
Q

Beta 2 blocker effect on

Lungs

A

Bronchoconstriction

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5
Q

Beta 2 blocker effect on liver

A

↓ Glycogenolysis
↓ Gluconeogenesis
*may cause hypoglycemia in diabetics

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6
Q

Effect of M1 stimulation on the brain

A

↑ Memory formation

↑ Cognitive functioning

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7
Q

Effect of M2 stimulation on the heart

A

↓ HR

↓ atrial contraction

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8
Q

Effect of M3 stimulation on peripheral vasculature

A

Smooth muscle relaxes
Vasodilation
Hypotention

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9
Q

Effect of M3 stimulation on lungs

A

Bronchoconstriction

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10
Q

Effect of M3 stimulation on bladder

A

Detrusor contraction

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11
Q

Effect of M3 stimulation on Eyes

A

Miosis (Pupillary sphincter muscle contraction)

Accommodation (Ciliary muscle contraction)

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12
Q

Effect of M3 stimulation on GI tract

A

↑ Peristalsis
↑ Salivary secretion
↑ Gastric secretion

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13
Q

Effect of M3 stimulation on skin

A

↑ sweat production

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14
Q

Effect of M3 inhibition on GI tract

A

Constipation
Dry mouth
↓ Gastric acid secretion

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15
Q

Effect of M3 inhibition on

Eyes

A

Mydriasis
Cycloplegia
+/– Acute angle Glaucoma

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16
Q

Effect of M3 inhibition on

Bladder

A

Detrusor Relaxation
Urinary retention
(full as a flask)

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17
Q

Effect of M3 inhibition on lungs

A

Bronchodilation

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18
Q

Anticholinergic clinical use

Scopolamine

A

Motion sickness

Sedation

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19
Q

Anticholinergic clinical use

Benztropine

A

Drug induced Parkinson’s

Sedation

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20
Q

Anticholinergic clinical use

Atropine

A

Heart Block
Sinus Bradycardia
(tachycardia)

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21
Q

Anticholinergic effects of
Atropine, Scopolamine
on secretions

A

↓ lacrimation, sweating, salivation, bronchial, GI secretions

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22
Q

Anticholinergic clinical use

Oxybutynin

A

Neurogenic spastic bladder

relaxes detrusor

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23
Q

Anticholinergic clinical use

ipratropium

A

COPD/ asthma

bronchodilation

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24
Q

Parasympathetic Nervous System has
___ Pre-synaptic Neurons
&
___ Post- synaptic Neurons

A

Long

Short

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25
Sympathetic Nervous System has ___ Pre-synaptic Neurons & ___ Post- synaptic Neurons
Short (SNS) Long
26
Somatic Nervous system controls
voluntary movement
27
Autonomic Nervous system controls
involuntary actions
28
All Pre-synaptic neurons release Ach and bind ___ receptors
Nicotinic
29
Skeletal muscle contains what type of receptor
Nicotinic (ion channels)
30
Sweat glands are innervated by what Nervous system?
Sympathetic
31
The adrenal glands are innervated by what Nervous system?
Sympathetic
32
Sweat Glands contain what type of receptor?
Muscarinic
33
M3 receptors use what type of receptor
Gq coupled GPCR
34
Beta 2 adrenergic receptors __ insulin secretion
↑
35
Alpha 2 adrenergic receptors __ insulin secretion
↓
36
M3 & Glucagon __ Insulin secretion
↑
37
List the effects of Anticholinergic toxicity (aka Muscarinic or Ach antagonist)
``` ↑ Body temp (Hot as a Hare) ↓ secretions (Dry as a bone) Flushed skin (Red as a beet) Mydriasis/Cycloplegia (Blind as a bat) Altered mental status (Mad as a hatter) Constipation/Urinary retention (full as a flask) Tachycardia (Fast as a fiddle) ```
38
Why does anticholinergic toxicity cause Tachycardia?
↓ Vagal tone at the SA node
39
Alpha 1 stimulation primary effects (3)
Peripheral Vasoconstriction Internal Urethral Constriction Pupillary Dilation
40
Alpha 2 stimulation primary effects (2)
↓ Insulin release | ↓ Intestinal motility
41
Beta 1 stimulation primary effects (3)
↑ Cardiac Contractility ↑ HR ↑ Renin
42
Beta 2 stimulation primary effects (2)
Peripheral Vasodilation Bronchodilation *Uterus relaxation (tocolysis)
43
Muscarinic 2 stimulation primary effects (2)
↓ Cardiac Contractility | ↓ HR
44
Muscarinic 3 stimulation primary effects (6)
``` Bronchoconstriction ↑ Insulin release ↑ Intestinal motility Detrusor Contraction Pupillary constriction Peripheral Vasodilation (via NO) ```
45
Alpha 1 stimulation causes what change in second messenger?
↑IP3
46
Alpha 2 stimulation causes what change in second messenger?
↓cAMP
47
Beta 1 stimulation causes what change in second messenger?
↑cAMP
48
Beta 2 stimulation causes what change in second messenger?
↑cAMP
49
M2 stimulation causes what change in second messenger?
↓cAMP
50
M3 stimulation causes what change in second messenger?
↑IP3
51
MOA: Midodrine Phenylephrine
alpha 1 agonist
52
MOA: Clonidine
alpha 2 agonist
53
MOA: Doxazosin Terazosin Prazosin
alpha 1 antagonist
54
alpha 1 & 2 antagonist
Phenoxybenzamine
55
Beta agonist
Isoproterenol
56
Beta 1 antagonist
Metoprolol | Atenolol
57
Low dose Epinephrine favors what receptors
B1> B2>A1
58
High dose Epinephrine favors what receptors
A1> B1> B2
59
phenylephrine
alpha 1 agonist
60
List the Cholinergic toxicity muscarinic and nicotinic effects.
``` Diarrhea/ Diaphoresis Urination Miosis Bronchospasm/ Bradycardia Emesis Lacrimation Salivation Nicotinic effects: Muscle weakness paralysis fasciculations ```

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