Flashcards in Nutritional Anemia Deck (46)
Enum two mechanisms of anemia
Low reticulocyte count
Decreased red cell survival
Micronutrient that is deficient in microcytic anemia
Condition of microcytic anemia that is secondary to globin chains
Condition of macrocytic anemia that is secondary to bone marrow disorders
Micronutrients that are deficient in macrocytic anemia
Anemia depicting decrease in all blood cell lines. Including RBC.
What supplement do doctors give aside fr vitamins, when anemia cause is unk?
Transport form of iron going to peripheral tissues
Stored forms of iron at body. Enumerate.
Iron store at blood:how many grams?
Circulating heme store at blood:how many grams? Give range.
Myoglobin, heme in cytochrome, ferrosome for complexes- store at blood:how many grams?
~ 0.3 grams
Lab tests done to test anemia: enumerate
CBC with differential
80% of body's iron is fr what system?
Reticulocyte endothelial system
Most readily absorbed form of iron
Vegetarians have 50% reduced Fe absorbe due to these two substances in certain vegetables
Phytate and phosphate
Vitamin that increases absorbed iron fr plants
Which is not a sign of iron deficiency?
A.spooning of nails
D.lack of clotting factors
Extremely high hemoglobin and hematocrit.usually seen in high altitude areas
Anemia that is Due to impaired DNA synthesis + lower cell div. leading to larger RBC
Receptor for attachment in salivary fluid; for VitB12 absorption
What splits R-B12 to form IF-B12
IF factor receptor is in the __, and it is for attachment
Which cells in the stomach produce intrinsic factor?
Gastric parietal cells
Which is not a consequence of Cobalamin Deficiency?
A. Too much IF
B. Mucosal cells problem
C. Autoinmune disease vs parietal cells
Too little dapat
Test measuring B12 deficiency, detect abnormal results in patients with genetic defect
Which has more severe GI manif?
A. Folate deficiency
B. Vit B12 deficiency
Which does not happen due to folate deficiency?
A. Severe neuro abnormalities
B. Hyposegmented neutrophils
C. Increase in mean cell volume
D. Decrease in hemoglobin
Folate draws away B12 from neurologic system for RBC Prod. T or F?
Diagnostic test for folate deficiency
Detect via RBC Folate
Number of RBC/oxygen-carrying capacity is insuff for physio needs. What is this?
how much can females lose in terms of Fe @ menstrual period? give range
Fe absorption takes place in the mucosa of the __
proximal small intestine
3 CAUSES OF IRON DEFICIENCY - ENUM
1. Increased demand for iron and/or hematopoiesis
2. Increased iron losses
3. Decreased iron intake or absorption
Treatment of Iron Deficiency: enum 3 methods
RBC transfusion (for blood loss)
Oral Iron Therapy
Enumerate three substances used for oral iron therapy
this parasite is involved in competition for cobalamin
false about pernicious anemia
A.most common cause of cobalamin deficiency
B.caused by the absence of IF
C.atrophy of mucosa
D.autoimmune destruction of chief cells
False about Stage 1 of Schilling test
A.oral dose of radiolabeled cobalamin given
simultaneously with an IM injection unlabeled
B.amount of radiolabeled activity is measured in feces
C.normal: > 7%
false about Schilling test, Stage 2
A. if Stage 1 is abnormal, then test is repeated following
60 mg of oral IF
B. if the level of urinary radiolabeled B12 normalizes,
then this indicates microcytic anemia
False about Schilling test, Stage 3
A. large intestine bacterial overgrowth may cause B12
B. small intestine bacterial overgrowth may be due to abnormal result in Stage 1 that
is not corrected with IF administration in Stage 2
C. broad spectrum antibiotics are given for one week to
eliminate intestinal bacteria
False about Schilling test,Stage 4
A. if pancreatic insufficiency exists, B12 malabsorption
B. normalization after pancreatic enzyme therapy
suggests pancreatic origin
C. Both are true
sprue - medical condition that causes __ malabsorption
phenytoin, barbiturates, ethanol cause __ malabsorption
in folate deficiency, what is formed first?
C.they are formed at the same time