Nutritional Anemia Flashcards Preview

PH 162 > Nutritional Anemia > Flashcards

Flashcards in Nutritional Anemia Deck (46)
1

Enum two mechanisms of anemia

Low reticulocyte count
Decreased red cell survival

2

Micronutrient that is deficient in microcytic anemia

Iron

3

Condition of microcytic anemia that is secondary to globin chains

Thalassemia

4

Condition of macrocytic anemia that is secondary to bone marrow disorders

Myelodysplasia

5

Micronutrients that are deficient in macrocytic anemia

VitB12
Folate

6

Anemia depicting decrease in all blood cell lines. Including RBC.

Normocytic

7

What supplement do doctors give aside fr vitamins, when anemia cause is unk?

Ferrosulfate

8

Transport form of iron going to peripheral tissues

Blood transferrin

9

Stored forms of iron at body. Enumerate.

Ferritin
Hemosiderin

10

Iron store at blood:how many grams?

2.5

11

Circulating heme store at blood:how many grams? Give range.

2-2.5

12

Myoglobin, heme in cytochrome, ferrosome for complexes- store at blood:how many grams?

~ 0.3 grams

13

Lab tests done to test anemia: enumerate

CBC with differential
Peripheral smears
Reticulocyte count

14

80% of body's iron is fr what system?

Reticulocyte endothelial system

15

Most readily absorbed form of iron

Heme iron

16

Vegetarians have 50% reduced Fe absorbe due to these two substances in certain vegetables

Phytate and phosphate

17

Vitamin that increases absorbed iron fr plants

Vit C

18

Which is not a sign of iron deficiency?
A.spooning of nails
B.conjunctival pallor
C.cheilosis
D.lack of clotting factors

D

19

Extremely high hemoglobin and hematocrit.usually seen in high altitude areas

Polycythemia vera

20

Anemia that is Due to impaired DNA synthesis + lower cell div. leading to larger RBC

Megaloblastic anemia

21

Receptor for attachment in salivary fluid; for VitB12 absorption

R-binder

22

What splits R-B12 to form IF-B12

Protease

23

IF factor receptor is in the __, and it is for attachment

Ileum

24

Which cells in the stomach produce intrinsic factor?

Gastric parietal cells

25

Which is not a consequence of Cobalamin Deficiency?
A. Too much IF
B. Mucosal cells problem
C. Autoinmune disease vs parietal cells

A

Too little dapat

26

Test measuring B12 deficiency, detect abnormal results in patients with genetic defect

Schilling test

27

Which has more severe GI manif?
A. Folate deficiency
B. Vit B12 deficiency
C. Equal

A

28

Which does not happen due to folate deficiency?
A. Severe neuro abnormalities
B. Hyposegmented neutrophils
C. Increase in mean cell volume
D. Decrease in hemoglobin

B

Hyper dapat

29

Folate draws away B12 from neurologic system for RBC Prod. T or F?

T

30

Diagnostic test for folate deficiency

Detect via RBC Folate

31

Number of RBC/oxygen-carrying capacity is insuff for physio needs. What is this?

Anemia

32

how much can females lose in terms of Fe @ menstrual period? give range

4-37mg/menstrual
cycle

33

Fe absorption takes place in the mucosa of the __

proximal small intestine

34

3 CAUSES OF IRON DEFICIENCY - ENUM

1. Increased demand for iron and/or hematopoiesis
2. Increased iron losses
3. Decreased iron intake or absorption

35

Treatment of Iron Deficiency: enum 3 methods

RBC transfusion (for blood loss)
Oral Iron Therapy
Parenteral Iron

36

Enumerate three substances used for oral iron therapy

ferrous sulfate
ferrous fumarate
ferrous gluconate

37

this parasite is involved in competition for cobalamin

Diphyllobothrium latum

38

false about pernicious anemia
A.most common cause of cobalamin deficiency
B.caused by the absence of IF
C.atrophy of mucosa
D.autoimmune destruction of chief cells

D

parietal dapat

39

False about Stage 1 of Schilling test
A.oral dose of radiolabeled cobalamin given
simultaneously with an IM injection unlabeled
cobalamin
B.amount of radiolabeled activity is measured in feces
C.normal: > 7%

B

urine dapat

40

false about Schilling test, Stage 2
A. if Stage 1 is abnormal, then test is repeated following
60 mg of oral IF
B. if the level of urinary radiolabeled B12 normalizes,
then this indicates microcytic anemia

B

41

False about Schilling test, Stage 3
A. large intestine bacterial overgrowth may cause B12
malabsorption
B. small intestine bacterial overgrowth may be due to abnormal result in Stage 1 that
is not corrected with IF administration in Stage 2
C. broad spectrum antibiotics are given for one week to
eliminate intestinal bacteria

A

small dapat

42

False about Schilling test,Stage 4
A. if pancreatic insufficiency exists, B12 malabsorption
may occur
B. normalization after pancreatic enzyme therapy
suggests pancreatic origin
C. Both are true

C

43

sprue - medical condition that causes __ malabsorption
A.folate
B.vit B12
C.iron
D.Vit A

A

44

phenytoin, barbiturates, ethanol cause __ malabsorption
A.folate
B.vit B12
C.iron
D.Vit A

A

45

in folate deficiency, what is formed first?
A.macroovalocytes
B.hypersegmented neutrophils
C.they are formed at the same time

B

46

@ FOLATE DEFICIENCY: peripheral blood and bone marrow biopsy look exactly like B12 deficiency. What is usually seen?

PMN, large RBC