ocular pharmacology 2 Flashcards Preview

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Flashcards in ocular pharmacology 2 Deck (21):
1

Latanoprost class

Prostaglandin analog

2

Latanoprost MOA

Lowers IOP by facilitating aqueous humor outflow through accessory uveoscleral pathway.

3

Latanoprost role in glaucoma treatment

First-line therapy in open-angle glaucoma as part of stepped approach.

4

Latanoprost SE

1. Brown discoloration of iris
2. eyelash lengthening
3. ocular irritation

5

Brimonidine Class

Alpha 2 adrenergic agonist

6

Brimonidine MOA

1. Increases uveoscleral outflow pathway
2. inhibits aqueous humor production.

7

Brimonidine Role in glaucoma treatment

Add-on 2nd or 3rd line therapy in open-angle glaucoma.

8

Brimonidine SE

1. Red eye
2. ocular irritation
3. CNS depression
4. apnea in neonates

9

Timolol class

Beta-adrenergic antagonist

10

Timolol MOA

Reduces aqueous humor production.

11

Timolol role in glaucoma treatment

Next most common drug used for open-angle glaucoma after prostaglandin analog.

12

Timolol SE

Systemic absorption leads to decreased HR, broncho-constriction.

13

Timolol contraindications

1. bradycardia
2. heart block
3. CHF
4. asthma
5. COPD

14

Dorzolamide Class

Carbonic anhydrase inhibitor

15

Dorzolamide MOA

Inhibiting CA in ciliary body epithelium reduces bicarb ion formation, leading to reduced fluid transport and IOP.

16

Dorzolamide role in glaucoma treatment

Add-on 2nd or 3rd line in open-angle glaucoma.

17

Dorzolamide SE

Few is applied topically

18

Pilocarpine class

Muscarinic receptor agonist

19

Pilocarpine MOA

Lowers IOP through contraction of ciliary muscle

(increases aqueous outflow)

20

Pilocarpine role in glaucoma

1. Used in treatment of closed-angle glaucoma
2. Not commonly used today for open-angle glaucoma

21

Pilocarpine SE

Ciliary spasm leading to HA, myopia, dim vision.