ocular pharmacology 2 Flashcards Preview

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Flashcards in ocular pharmacology 2 Deck (21)
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1
Q

Latanoprost class

A

Prostaglandin analog

2
Q

Latanoprost MOA

A

Lowers IOP by facilitating aqueous humor outflow through accessory uveoscleral pathway.

3
Q

Latanoprost role in glaucoma treatment

A

First-line therapy in open-angle glaucoma as part of stepped approach.

4
Q

Latanoprost SE

A
  1. Brown discoloration of iris
  2. eyelash lengthening
  3. ocular irritation
5
Q

Brimonidine Class

A

Alpha 2 adrenergic agonist

6
Q

Brimonidine MOA

A
  1. Increases uveoscleral outflow pathway

2. inhibits aqueous humor production.

7
Q

Brimonidine Role in glaucoma treatment

A

Add-on 2nd or 3rd line therapy in open-angle glaucoma.

8
Q

Brimonidine SE

A
  1. Red eye
  2. ocular irritation
  3. CNS depression
  4. apnea in neonates
9
Q

Timolol class

A

Beta-adrenergic antagonist

10
Q

Timolol MOA

A

Reduces aqueous humor production.

11
Q

Timolol role in glaucoma treatment

A

Next most common drug used for open-angle glaucoma after prostaglandin analog.

12
Q

Timolol SE

A

Systemic absorption leads to decreased HR, broncho-constriction.

13
Q

Timolol contraindications

A
  1. bradycardia
  2. heart block
  3. CHF
  4. asthma
  5. COPD
14
Q

Dorzolamide Class

A

Carbonic anhydrase inhibitor

15
Q

Dorzolamide MOA

A

Inhibiting CA in ciliary body epithelium reduces bicarb ion formation, leading to reduced fluid transport and IOP.

16
Q

Dorzolamide role in glaucoma treatment

A

Add-on 2nd or 3rd line in open-angle glaucoma.

17
Q

Dorzolamide SE

A

Few is applied topically

18
Q

Pilocarpine class

A

Muscarinic receptor agonist

19
Q

Pilocarpine MOA

A

Lowers IOP through contraction of ciliary muscle

increases aqueous outflow

20
Q

Pilocarpine role in glaucoma

A
  1. Used in treatment of closed-angle glaucoma

2. Not commonly used today for open-angle glaucoma

21
Q

Pilocarpine SE

A

Ciliary spasm leading to HA, myopia, dim vision.