Flashcards in ocular pharmacology 2 Deck (21):
Lowers IOP by facilitating aqueous humor outflow through accessory uveoscleral pathway.
Latanoprost role in glaucoma treatment
First-line therapy in open-angle glaucoma as part of stepped approach.
1. Brown discoloration of iris
2. eyelash lengthening
3. ocular irritation
Alpha 2 adrenergic agonist
1. Increases uveoscleral outflow pathway
2. inhibits aqueous humor production.
Brimonidine Role in glaucoma treatment
Add-on 2nd or 3rd line therapy in open-angle glaucoma.
1. Red eye
2. ocular irritation
3. CNS depression
4. apnea in neonates
Reduces aqueous humor production.
Timolol role in glaucoma treatment
Next most common drug used for open-angle glaucoma after prostaglandin analog.
Systemic absorption leads to decreased HR, broncho-constriction.
2. heart block
Carbonic anhydrase inhibitor
Inhibiting CA in ciliary body epithelium reduces bicarb ion formation, leading to reduced fluid transport and IOP.
Dorzolamide role in glaucoma treatment
Add-on 2nd or 3rd line in open-angle glaucoma.
Few is applied topically
Muscarinic receptor agonist
Lowers IOP through contraction of ciliary muscle
(increases aqueous outflow)
Pilocarpine role in glaucoma
1. Used in treatment of closed-angle glaucoma
2. Not commonly used today for open-angle glaucoma