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Pharmocology > Pain Part 2 (Non-Opioids).pptx > Flashcards

Pain Part 2 (Non-Opioids).pptx Flashcards

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1
Q

Injuries can release an ?

a. neuropathic pain
b. inflammatory soup

A

inflammatory soup

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2
Q

Inflammatory Soup includes ?

a. oxytocin
b. prostaglandins

A

b. prostaglandins

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3
Q

Which causes pain and inflammation?

a. oxytocin
b. prostaglandins

A

b. prostaglandins

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4
Q

Which help with inflammation.?
a. NSAIDS (ibuprofen)
B. OPIODS (morphine)

A

a. NSAIDS (ibuprofen)

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5
Q

Which treat MODERATE TO SEVERE pain
a. NSAIDS (ibuprofen)
B. OPIODS (morphine)

A

B. OPIODS (morphine)

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6
Q

Inflamation is considered

a. Mild
b. Moderate
c. Severe

A

a. Mild

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7
Q

protective prostaglandins in stomach

a. Cox 1 pathway
b. Cox 2 pathway

A

a. Cox 1 pathway

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8
Q

Inflammatory prostaglandins ;hyperalgesia

a. Cox 1 pathway
b. Cox 2 pathway

A

b. Cox 2 pathway

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9
Q

? are a group of lipids made at sites of tissue damage or infection that are involved in dealing with injury and illness.

a. hyperalgesia
b. prostaglandins
c. PGI2- Prostacyclin)
d. PGI1- Prostacyclin)

A

b. prostaglandins

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10
Q

Which is abnormally heightened sensitivity to pain?

a. hyperalgesia
b. prostaglandins

A

a. hyperalgesia

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11
Q

Vasodilation (blood vessels, kidneys)

a. hyperalgesia
b. prostaglandins
c. PGI2- Prostacyclin)
d. PGI1- Prostacyclin)

A

b. prostaglandins

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12
Q

Inflammation and pain

a. hyperalgesia
b. prostaglandins
c. PGI2- Prostacyclin)
d. PGI1- Prostacyclin)

A

b. prostaglandins

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13
Q

Stop platelet aggregation

a. hyperalgesia
b. prostaglandins
c. PGI2- Prostacyclin)
d. PGI1- Prostacyclin)

A

b. prostaglandins

c. PGI2- Prostacyclin)

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14
Q

Protect gastric mucosaa. hyperalgesia

a. hyperalgesia
b. prostaglandins
c. PGI2- Prostacyclin)
d. PGI1- Prostacyclin)

A

b. prostaglandins

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15
Q

Cyclooxygenase (COX-I, COX-II)

  1. Tissue Injury- ?- promote inflammation and sensitize receptors to pain
  2. Stomach- ?- help protect gastric mucosa
  3. Platelets-?- stimulates platelet aggregation
  4. Blood vessels- ? causes vasodilation, inhibits platelet aggregation
  5. Kidney-?- causes vasodilation- maintains renal blood flow
  6. Brain- ?- Fever and perception of pain
  7. Uterus- ?- Promote contractions at term
    a. PG- prostaglandins
    b. TXA2 thromboxane
A
  1. a. PG- prostaglandins
  2. a. PG- prostaglandins
  3. b. TXA2 thromboxane
  4. a. PG- prostaglandins
  5. a. PG- prostaglandins
  6. a. PG- prostaglandins
  7. a. PG- prostaglandins
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16
Q 
Location- Effect of COX INHIBITION (NSAID use)
Stomach- Gastric ulceration
a. Cox 1
b. Cox 2
c. Both
A

a. Cox 1

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17
Q

Location- Effect of COX INHIBITION (NSAID use)
Platelets- Bleeding; protection against MI* (ASA)
a. Cox 1
b. Cox 2
c. Both

A

a. Cox 1

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18
Q

Location- Effect of COX INHIBITION (NSAID use)
Blood vessels(endothelial cells)- Blood vessels(endothelial cells)
a. Cox 1
b. Cox 2
c. Both

A

b. Cox 2

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19
Q

Location- Effect of COX INHIBITION (NSAID use)
Kidney- Renal impairment; disrupted Na+ and H2O balance
a. Cox 1
b. Cox 2
c. Both

A

c. Both

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20
Q

Location- Effect of COX INHIBITION (NSAID use)
Injured tissue- Reduced inflammation and reduced pain
a. Cox 1
b. Cox 2
c. Both

A

b. Cox 2

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21
Q 
Location- Effect of COX INHIBITION (NSAID use)
Brain- Reduced fever and reduced pain
a. Cox 1
b. Cox 2
c. Both
A

b. Cox 2

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22
Q

Good?

a. Cox 1
b. Cox 2
c. Both

A

a. Cox 1

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23
Q

Bad?

a. Cox 1
b. Cox 2
c. Both

A

b. Cox 2

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24
Q

Select all that applies to Cox 1

a. Colon – “colon cancer”
b. Gastric mucosa protection
c. Blood vessels- dilation
d. Platelet aggregation
e. stops platelet aggregation
f. Supports renal function
g. Sites of tissue injury “inflammation”
h. in brain- mediates fever and pain

A

b. Gastric mucosa protection
d. Platelet aggregation
f. Supports renal function

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25
Select all that applies to Cox 2 a. Colon – “colon cancer” b. Gastric mucosa protection c. Blood vessels- dilation d. Platelet aggregation e. stops platelet aggregation f. Supports renal function g. Sites of tissue injury “inflammation” h. in brain- mediates fever and pain
a. Colon – “colon cancer” c. Blood vessels- dilation e. stops platelet aggregation g. Sites of tissue injury “inflammation” h. in brain- mediates fever and pain
26
? stimulates platelet aggregation a. Prostacyclin, PGI2- b. TXA2
b. TXA2
27
Stop platelet aggregation a. Prostacyclin, PGI2- b. TXA2
a. Prostacyclin, PGI2-
28
Which is Prostaglandins? a. Generally cause VASODILATION b. PROTECT the GI Tract c. Cause PAIN and FEVER d. Causes platelets to form a platelet plug e. Precursor to a blood clot
a. Generally cause VASODILATION b. PROTECT the GI Tract c. Cause PAIN and FEVER
29
Which is TXA2 (Thromboxane) a. Generally cause VASODILATION b. PROTECT the GI Tract c. Cause PAIN and FEVER d. Causes platelets to form a platelet plug e. Precursor to a blood clot
d. Causes platelets to form a platelet plug | e. Precursor to a blood clot
30
Our 1. ( NSAIDS or OPIOIDS ) block prostaglandins. They reduce PAIN and FEVER, but you 2. (Lose or Keep) the protection of the GI Tract (these can cause stomach ulcers)
1. NSAIDS | 2. Lose
31
Salicylates= a. Reversible b. Irreversible
b. Irreversible
32
Non-Salicylates= a. Reversible b. Irreversible
a. Reversible
33
Aspirin= a. Non-Salicylates b. Salicylates
b. Salicylates
34
Aspirin are ? a. Reversible b. Irreversible
b. Irreversible
35
Which applies to aspirin? a. Rheumatoid Arthritis b. Osteoarthritis c. Joint pain, swelling, inflammation (arthritis, tendonitis, d. bursitis, etc.) e. Fever f. Mild – moderate pain g. Pain
a. Rheumatoid Arthritis b. Osteoarthritis c. Joint pain, swelling, inflammation (arthritis, tendonitis, d. bursitis, etc.) e. Fever
36
is an autoimmune disease that can cause joint pain and damage throughout your body. a. Osteoarthritis b. Rheumatoid Arthritis
b. Rheumatoid Arthritis
37
A type of arthritis that occurs when flexible tissue at the ends of bones wears down. a. Osteoarthritis b. Rheumatoid Arthritis
a. Osteoarthritis
38
you lose the cardio protective benefit a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
b. Aspirin
39
What is the half life of aspirin and what time period you should take them?
20 | 4-6 hours
40
Aspirin-WHY DO WE USE FOR STROKE/MYOCARDIAL INFARCTION PREVENTION? Select a. Irreversibly binds to COX enzymes (2) of platelets b. Irreversibly binds to COX enzymes (1&2) of platelets c. Inhibits the action of COX for entire life of platelet d. Promotes the action of COX for entire life of platelet
b. Irreversibly binds to COX enzymes (1&2) of platelets | c. Inhibits the action of COX for entire life of platelet
41
Should aspirin be taken with food? | Yes or No
Yes, to avoid nausea
42
1. Should aspirin be taken with food? 2. And does it irritate the stomach lining? Yes or No
Yes, Gastric distress, heartburn, nausea | Yes
43
Since aspirin causes Gastric bleeding / ulceration which patients are more at risk? a. smokers b. alcohol users c. PUD (peptic ulcer disease) patient d. All
d. All
44
Why do Reye syndrome develop in children with aspirin a. it doesn't b. Viral Infection c. Children <12 should not be taking Aspirin d. Children <12 can be taking Aspirin
b. Viral Infection | c. Children <12 should not be taking Aspirin
45
Do aspirin (promote or inhibit )platelets (thromboxane A2) resulting bleeding
inhibit
46
Which drug has Salicylism toxicity? a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
b. Aspirin
47
Which is side effects of Salicylism toxicity a. Tinnitus b. Sweating c. Headache d. Dizziness e. N/V/D f. N/V/C g. Respiratory Alkalosis (rapid breathing) h. Respiratory Acidosis (decrease breathing)
a. Tinnitus b. Sweating c. Headache d. Dizziness e. N/V/D g. Respiratory Alkalosis (rapid breathing)
48
Aspirin can only be given to children with which iliness a. Lupus b. Cancer c. Kawasaki
c. Kawasaki
49
What increases the risk of bleeding when taken with aspirin. a. Warfarin b. Steroids c. Smoking d. Alcohol e. Other NSAIDs f. Heparin.
a. Warfarin c. Smoking d. Alcohol f. Heparin.
50
Which increases the risk of GI tract complications (risk for ulcer/bleed) with aspirin a. Warfarin b. Steroids c. Smoking d. Alcohol e. Other NSAIDs f. Heparin.
b. Steroids
51
Which cause more adverse side effect while taken with aspirin? a. Warfarin b. Steroids c. Smoking d. Alcohol e. Other NSAIDs f. Heparin.
e. Other NSAIDs
52
Which are First generation NSAIDS a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
a. ibuprofen e. naproxen c. Ketorolac g. indomethacin h. diclofenac
53
What do First generation NSAIDS:ibuprofen, naproxen, ketorolac, indomethacin, diclofenac treat? a. Rheumatoid Arthritis b. Osteoarthritis c. Joint pain, swelling, inflammation (arthritis, tendonitis, d. bursitis, etc.) e. Fever f. Mild – moderate pain g. Pain
c. Joint pain, swelling, inflammation (arthritis, tendonitis, d. bursitis, etc.) e. Fever f. Mild – moderate pain
54
Is First generation NSAIDS:ibuprofen, naproxen, ketorolac, indomethacin, diclofenac similar to aspirin? Yes or No
No
55
Where does this suffix go? profen a. first generation b. second generation c. Herbals
a. first generation
56
Where does this suffix go? fenac a. first generation b. second generation c. Herbals
a. first generation
57
Which reversibly inhibits Cox 1 and 2 pathways a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
first generation a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac
58
Which stop prostaglandin in both Cox 1 and Cox 2 a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac
59
Which first generation NSAIDs should be used only 5 days max due to GI Bleeding a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
c. Ketorolac
60
Which causes Increased blood pressure (MI/Stroke) a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac j. celecoxib
61
Which cause renal impairment (potential for AKI) a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac j. celecoxib
62
Which can Not to be used in heart failure (sodium/fluid retention) a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac j. celecoxib
63
Which reduces (MI and Strokes) a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
b. Aspirin
64
``` Which treats Joint pain, swelling, inflammation (arthritis, tendinitis, bursitis, etc.) Fever Mild – moderate pain a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib ```
a. ibuprofen c. Ketorolac e. naproxen g. indomethacin h. diclofenac j. celecoxib
65
Which Selectively inhibits COX-2 enzyme a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
j. celecoxib
66
Which NSAIDS should avoid with SULFA Allergy? a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
j. celecoxib
67
Which is a non Nsaids a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
68
Which just treats Pain or Fever a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
69
Works on hypothalamus (heat regulating center)= treats fevers a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
70
Works on hypothalamus (heat regulating center)= treats fevers a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
71
Which NSAIDS or NON NSAIDS do NOT help with Inflammation a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
72
Which have NO gastric ulceration, renal impairment, bleeding! a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
73
Which has LIVER TOXIcity a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
74
High doses of Acetaminophen result in large levels of toxic metabolite and rapidly deplete ? a. fluoxetine b. glutathione
b. glutathione
75
``` Do not exceed Acetaminophen ? mg/dose FDA says do not exceed ? mg/day A. 2000 b. 1000 c. 4000 ```
1000 | 4000
76
If you drink more than 3 alcoholic beverages day- MAX is Acetaminophen ? mg/day A. 2000 b. 1000 c. 4000
2000
77
Which is tylenol, paracetamol, APAP a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
78
Which is safe for children and is weight based? a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen
79
Which of the following are signs of an over dose a. ASYMPTOMATIC b. Diaphoresis, c. N/V/D d. This damages Liver- LFTS will rise
All
80
This an antidote for Acetylcysteine (Acetadote®) a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib k. Acetylcysteine
i. Acetaminophen
81
``` Mucolytic is the Inhaled version to thin secretions What os used for Acetaminophen overdose a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib k. Acetylcysteine ```
k. Acetylcysteine
82
Which Oral Version- Smells like rotten eggs a. ibuprofen b. Aspirin c. Ketorolac d. Glucosamine + Chondroitin e. naproxen f. Feverfew g. indomethacin h. diclofenac i. Acetaminophen j. celecoxib
i. Acetaminophen

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