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Pharmocology > Psych.pptx > Flashcards

Psych.pptx Flashcards

1
Q

Which are names of ANTIPSYCHOTIC

a. Antipsychotics
b. Neuroleptics
c. Dopamine Antagonists”
d. Dopamine/Serotonin Antagonists

A

All

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2
Q

Which isANTIPSYCHOTIC used for ?

a. Hallucinations
b. Delusions
c. Schizophrenia
d. Paranoia
e. Bipolar Disorder
g. Nausea/Vomiting

A

All

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3
Q

First Generation Antipsychotics:

a. low potency
b. Moderate Dopamine Antagonists
c. high potency
d. Atypical
e. FGA
f. Conventional
g. SGA
h. Added Serotonin Antagonist properties
i. Primary Mechanism: STRONG Dopamine Antagonists

A

a. low potency
c. high potency
e. FGA
f. Conventional
i. Primary Mechanism: STRONG Dopamine Antagonists

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4
Q

Second Generation Antipsychotics:

a. low potency
b. Moderate Dopamine Antagonists
c. high potency
d. Atypical
e. FGA
f. Conventional
g. SGA
h. Added Serotonin Antagonist properties
i. Primary Mechanism: STRONG Dopamine Antagonis

A

b. Moderate Dopamine Antagonists
d. Atypical
g. SGA
h. Added Serotonin Antagonist properties

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5
Q

Which drugs are First Generation Antipsychotics:

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

a Chlorpromazine

c haloperidol

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6
Q

Which is High Potency (FGA)

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

c. haloperidol

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7
Q

Which is Low Potency (FGA)

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

a. Chlorpromazine

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8
Q

Which drugs are Second Generation Antipsychotics:

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

d. clozapine

e. risperidone

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9
Q

Which are Mood Stabilizer

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

b. LITHIUM

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10
Q

Which has a STRONG Blockade of D2 receptors

a. Chlorpromazine - FGA
b. LITHIUM- Mood Stabilizer
c. haloperidol - FGA
d. clozapine SGA
e. risperidone - SGA

A

a. Chlorpromazine - FGA

c. haloperidol - FGA

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11
Q

FGA blocks which?

a. Histamine
b. NE (alpha-1)
c. Acetylcholine (muscarinic)
d. 5HT
e. METABOLIC

A

a. Histamine
b. NE (alpha-1)
c. Acetylcholine (muscarinic)
d. 5HT

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12
Q 
What is the common Adverse side effects for all FGA?
H-
O-
M-
E-
L-
E-
S-
S-
A 
Heart Problems
Orthostatic Hypotension
Muscarinic Blockade
Extrapyramidal Symptoms (Know all 4!)
Life threatening 
Neuroleptic Malignant Syndrome
Extremely Sedated
Sexual Dysfunction
Seizures/ Size Increase/Sunlight/ Skin!
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13
Q

Which are Dopamine Blockade?

a. Nigrostriatal- EPS
b. Mesocortical-associated with negative
c. Mesolimbic- treat positive symptoms
d. Tuberoinfundibular- Hyperprolactinemia

A

a. Nigrostriatal- EPS
b. Mesocortical-associated with negative
c. Mesolimbic- treat positive symptoms
d. Tuberoinfundibular- Hyperprolactinemia

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14
Q

Dopamine Blockade- treat positive symptoms

a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-

A

c. Mesolimbic-

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15
Q

Dopamine Blockade- treat positive symptoms

a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-

A

c. Mesolimbic-

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16
Q

Dopamine Blockade - Hyperprolactinemia

a. Nigrostriatal-
b. Mesocortical-
c. Mesolimbic-
d. Tuberoinfundibular-

A

d. Tuberoinfundibular-

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17
Q

What are the 4 EXTRAPYRAMIDAL SYMPTOMS (EPS)

a. Pseudoparkinsons
b. Nigrostriatal-
c. Akathisia
d. Mesocortical-
e. Mesolimbic-
f. Acute dystonia
g. Tuberoinfundibular-
h. Tardive Dyskinesia

A

a. Pseudoparkinsons
c. Akathisia
f. Acute dystonia
h. Tardive Dyskinesia

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18
Q

What are the 4 EXTRAPYRAMIDAL SYMPTOMS (EPS)

a. Pseudoparkinsons
b. Nigrostriatal-
c. Akathisia
d. Mesocortical-
e. Mesolimbic-
f. Acute dystonia
g. Tuberoinfundibular-
h. Tardive Dyskinesia

A

a. Pseudoparkinsons
c. Akathisia
f. Acute dystonia
h. Tardive Dyskinesia

19
Q 
What treats the 4  EXTRAPYRAMIDAL SYMPTOMS
anticholinergics
a. Benztropine (Cogentin®)
b. Trihexyphenidyl, 
c. Diphenhydramine
d. Haloperidol
e. DANTROLENE
A

a. Benztropine (Cogentin®)
b. Trihexyphenidyl,
c. Diphenhydramine

20
Q

What treats NEUROLEPTIC MALIGNANT SYNDROME:

a. Benztropine (Cogentin®)
b. Trihexyphenidyl,
c. Diphenhydramine
d. Haloperidol
e. DANTROLENE

A

e. DANTROLENE

21
Q 
NEUROLEPTIC MALIGNANT SYNDROME Halperadole
F
E
V
E
R
A 
Fever
Encephalopathy
Vitals Unstable
Elevated enzymes (CPK)
Rigidity
22
Q

Don’t touch the oral solution?

a. can not cause contact dermatitis!
b. can cause contact dermatitis!

A

b. can cause contact dermatitis!

23
Q

Which inhibit D2 (moderate) and 5HT (strong)

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

b. 2nd Generation Anti-psychotics

24
Q

Which is LESS likely to cause EPS

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

b. 2nd Generation Anti-psychotics

25
Q

Which has Metabolic Syndrome!

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

b. 2nd Generation Anti-psychotics

26
Q

so naturally, Cost $$$ More

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

b. 2nd Generation Anti-psychotics

27
Q

Which can cause dysrhythmias and DEATHBOXED WARNING: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

both

28
Q

Which mixed serotonin-dopamine antagonist activity that binds to 5-HT2-receptors in the CNS and in the periphery with a very high affinity; binds to dopamine-D2 receptors with less affinity

a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics

A

b. 2nd Generation Anti-psychotics

29
Q

What is associated with Monitor for Metabolic Syndrome

a. Glucose
b. cholesterol
c. weight gain

A

All

30
Q

Which drug deals with

  1. Increased mortality in elderly patients with dementia-related psychosis
  2. 2)Orthostatic hypotension, bradycardia, syncope
  3. Seizures
    4) Myocarditis and cardiomyopathy:
  4. 5) Severe neutropenia (1% patients):
    a. Chlorpromazine
    b. LITHIUM
    c. haloperidol
    d. clozapine
    e. risperidone
A

d. clozapine

31
Q 
Which deal with
elevated prolactin (hyperprolactinemia)
General Sexual dysfunction
Gynecomastia
Galactorrhea
Menstrual irregularities
a. 1st Generation Anti-psychotics
b. 2nd Generation Anti-psychotics
A

Both

32
Q

Which drug uses REM

a. Chlorpromazine
b. LITHIUM
c. haloperidol
d. clozapine
e. risperidone

A

d. clozapine

33
Q

1st Generation

a. ADDED METABOLIC SYNDROME
b. HIGH RISK FOR EPS
c. higher dopamine blockade (D2)
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms

A

b. HIGH RISK FOR EPS

c. higher dopamine blockade (D2)

34
Q

2nd Generation

a. ADDED METABOLIC SYNDROME
b. HIGH RISK FOR EPS
c. higher dopamine blockade (D2)
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms

A

a. ADDED METABOLIC SYNDROME
d. less dopamine blockade (D2), more 5HT
e. LESS EPS symptoms

35
Q 
1st Generation adverse side effects
H
O
M
E
L
E
S
S
Size Increase/Sunlight/Skin
Extrapyramidal Symptoms
Muscarinic Blockade
Orthostatic Hypotension 
Sexual DysfunctionSeizures
Extremely Sedated
Life threatening Neuroleptic Malignant Syndrome
Heart Problems
METABOLIC SYNDROME!
A 
Heart Problems
Orthostatic Hypotension 
Muscarinic Blockade
Extrapyramidal Symptoms
Life threatening Neuroleptic Malignant Syndrome
Extremely Sedated
Sexual DysfunctionSeizures
Size Increase/Sunlight/Skin
36
Q 
2nd Generation adverse side effects
H
O
M
E
L
E
S
S
Size Increase/Sunlight/Skin
Extrapyramidal Symptoms
Muscarinic Blockade
Orthostatic Hypotension 
Sexual DysfunctionSeizures
Extremely Sedated
Life threatening Neuroleptic Malignant Syndrome
Heart Problems
METABOLIC SYNDROME!
A 
Heart Problems
Orthostatic Hypotension 
Muscarinic Blockade: METABOLIC SYNDROME!
Extrapyramidal Symptoms
Life threatening Neuroleptic Malignant Syndrome
Extremely Sedated
Sexual DysfunctionSeizures
Size Increase/Sunlight
37
Q

Which is true about lithium

a. if high sodium, body reabsorbs sodium, and also lithium
b. if low sodium, body reabsorbs sodium, and also lithium

A

b. if low sodium, body reabsorbs sodium, and also lithium

38
Q

Which is true about lithium

a. if high sodium, body reabsorbs sodium, and also lithium
b. if low sodium, body reabsorbs sodium, and also lithium
c. normal sodium and fluid levels aren’t essential
d. normal sodium and fluid levels are essential
e. risks- dehydration, diarrhea,

A

b. if low sodium, body reabsorbs sodium, and also lithium
d. normal sodium and fluid levels are essential
e. risks- dehydration, diarrhea,

39
Q

Which of the following can lower sodium and increase lithium toxicity

a. Diuretics
b. OPIOIDs
c. NSAIDs
d. ACE-I ◦
e. Any drying out drug- Anticholinergics, Tricyclic Anti-depressants

A

a. Diuretics
c. NSAIDs
d. ACE-I ◦
e. Any drying out drug- Anticholinergics, Tricyclic Anti-depressants

40
Q

What are this seizures, ataxia, blurred vision, involuntary muscle movements, renal failure, coma, EKG changes, severe hypotension, death

a. Opiod overdose
b. lithium overdose

A

b. lithium overdose

41
Q

This can treat Gastric lavage, potentially hemodialysis

a. Opiod overdose
b. lithium overdose

A

b. lithium overdose

42
Q

Does lithium have muttiple have lives and should be given with food
Yes or No

A

yes

43
Q

Lithium- .? to ? mEq/L

A

.6

1.2

44
Q 
L
I
T
H
I
U
M
A

L evels (0.6-1.2 mEq/L)
Increased urination (polyuria)Insipidus
TremorsThirst
Hypothyroidism
Interactions (NSAIDS,ACE-Is,Diuretic, etc.)
Upset stomach
Muscle weakness/ Miscellaneous- EKG changes)

Pharmocology (36 decks)

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