Flashcards in Pharm NT II Deck (52):
1
What does glycine do
ligant gated Cl Ch
2
what toxin inhibits glycine release
tatanus
3
what is antagonist for glycine
strychnine
4
glycine also acts as agonist where
NMDA R
5
synthesis Ach
presynaptic terminal from choline and acetyl CoA
6
what helps store Ach
vesicle associated transporter
7
inactivation Ach
ACHE
8
R activated by Ach
ionotropic (nicotinic)
metabotropic (muscarinic)
9
agonist for ionotropic Ach
nicotine
10
antagonist for ionotropic Ach
curare like drugs (nondepolarizing neuromuscular blockers)
11
M1 Ach R
excitatory
dec K increase IP3 and DAG
12
M2 type Ach R
increase K
dec cAMP
inhibitory
13
agonist to muscarininc Ach R
muscarine and pilocarpine
14
antagonist to muscarininc Ach R
atropine and glycopyrrolate
15
roles of Ach in CNA
midbrain reticular formation- wakefulness
basal ganglia-motor control
basal forebrain- connections to hippocampus and Cx
16
Ach in Alzheimers
reduced production choline acetyl transferase dec Ach synthesis and impaired cortical cholinergic function
17
used to treat alzhemiers to counter dec in Ach production
ACHE inhibitors
18
What NMJ diseases involve Ach dysregulation
myasthenia gravis
Eaton Lambert Syndrome
botulism
19
what occurs when CNA Ach R blocked
drowsiness, sedation and memory loss
20
dopamine synthesis
presynatpic terminal form tyrosine
21
storage dopamine
loaded by vesciular monoamine transporter
22
inactivaiton dopamine
reuptake into presynaptic cells mediated by dopamine transporter DAT(majoirty) and plasma membrane monoamine transpoters
23
dopamine R
D1-5
24
D1 R activation causes what
increase cAMP
stimulatory
25
D2 R activation
inhibitory
postsynaptic increase K decrease cAMP
presynaptic dec Ca
26
where are the cell bodies of dopaminergic neurons
midbrain with substantia nigra pars compacta and in hypothalamus
27
what do midbrain dopaminergic neurons influence
motor control, emotion, motivation and cognitive processes like memory
28
Parkinsons
DA neurons in striatum degenerate
29
shizophrenia/psychosis
increased dopaminergic activity
30
what is used to Tx shizophrenia
D2 R antagonists
31
how does cocaine effect dopamine
DA uptake blockate
32
amphetamines change dopamine how
increase dopamine release
33
reward pathway
ventral tegmental dopamine pathways that mediate subjective effects of drugs of abuse
34
norepi synthesis
NE granules from dopamine by dopamine beta hyroxylase
35
storage NE
in grnaules where made
36
inactivation NE
reuptake mediated by norepri transporter
37
what R noes norepi work on
metabotropic
alpha 1 2
beta 1,2,3
38
a1 stimulation by NE
excitatory
dec K, increase IP3 and DAG
39
agonist for alpha 1 R
phenyleprhine
40
antagonist for alpha 1 R
phentolamine, prasozin
41
activation alpha 2 R
inhibitory
postsynaptic inc K dec cAMP
pre: dec Ca
42
agonist alpha 2
clonidine
43
antagonist to alpha2
yohimbine
44
activation beta 1
exctitatory
dec K increase cAMP
45
agonist beta 1
isoproterenol
46
antagonist beta1
propranolol
47
activation beta 2
excitatory
increase cAMP
48
agonist beta 2
albtuerol
49
antaonist beta 2
butoxamine
50
where are cell bodies for noradrenergic neurons
locus ceruleus
51
what do NE neurons modulate
sleep, wakefulness, attention and feeding behaviors
52