Flashcards in Pharm NT II Deck (52)
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1
What does glycine do
ligant gated Cl Ch
2
what toxin inhibits glycine release
tatanus
3
what is antagonist for glycine
strychnine
4
glycine also acts as agonist where
NMDA R
5
synthesis Ach
presynaptic terminal from choline and acetyl CoA
6
what helps store Ach
vesicle associated transporter
7
inactivation Ach
ACHE
8
R activated by Ach
ionotropic (nicotinic)
metabotropic (muscarinic)
9
agonist for ionotropic Ach
nicotine
10
antagonist for ionotropic Ach
curare like drugs (nondepolarizing neuromuscular blockers)
11
M1 Ach R
excitatory
dec K increase IP3 and DAG
12
M2 type Ach R
increase K
dec cAMP
inhibitory
13
agonist to muscarininc Ach R
muscarine and pilocarpine
14
antagonist to muscarininc Ach R
atropine and glycopyrrolate
15
roles of Ach in CNA
midbrain reticular formation- wakefulness
basal ganglia-motor control
basal forebrain- connections to hippocampus and Cx
16
Ach in Alzheimers
reduced production choline acetyl transferase dec Ach synthesis and impaired cortical cholinergic function
17
used to treat alzhemiers to counter dec in Ach production
ACHE inhibitors
18
What NMJ diseases involve Ach dysregulation
myasthenia gravis
Eaton Lambert Syndrome
botulism
19
what occurs when CNA Ach R blocked
drowsiness, sedation and memory loss
20
dopamine synthesis
presynatpic terminal form tyrosine
21
storage dopamine
loaded by vesciular monoamine transporter
22
inactivaiton dopamine
reuptake into presynaptic cells mediated by dopamine transporter DAT(majoirty) and plasma membrane monoamine transpoters
23
dopamine R
D1-5
24
D1 R activation causes what
increase cAMP
stimulatory
25
D2 R activation
inhibitory
postsynaptic increase K decrease cAMP
presynaptic dec Ca
26
where are the cell bodies of dopaminergic neurons
midbrain with substantia nigra pars compacta and in hypothalamus
27
what do midbrain dopaminergic neurons influence
motor control, emotion, motivation and cognitive processes like memory
28
Parkinsons
DA neurons in striatum degenerate
29
shizophrenia/psychosis
increased dopaminergic activity
30
