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Flashcards in Pharm NT II Deck (52):
1

What does glycine do

ligant gated Cl Ch

2

what toxin inhibits glycine release

tatanus

3

what is antagonist for glycine

strychnine

4

glycine also acts as agonist where

NMDA R

5

synthesis Ach

presynaptic terminal from choline and acetyl CoA

6

what helps store Ach

vesicle associated transporter

7

inactivation Ach

ACHE

8

R activated by Ach

ionotropic (nicotinic)
metabotropic (muscarinic)

9

agonist for ionotropic Ach

nicotine

10

antagonist for ionotropic Ach

curare like drugs (nondepolarizing neuromuscular blockers)

11

M1 Ach R

excitatory
dec K increase IP3 and DAG

12

M2 type Ach R

increase K
dec cAMP
inhibitory

13

agonist to muscarininc Ach R

muscarine and pilocarpine

14

antagonist to muscarininc Ach R

atropine and glycopyrrolate

15

roles of Ach in CNA

midbrain reticular formation- wakefulness
basal ganglia-motor control
basal forebrain- connections to hippocampus and Cx

16

Ach in Alzheimers

reduced production choline acetyl transferase dec Ach synthesis and impaired cortical cholinergic function

17

used to treat alzhemiers to counter dec in Ach production

ACHE inhibitors

18

What NMJ diseases involve Ach dysregulation

myasthenia gravis
Eaton Lambert Syndrome
botulism

19

what occurs when CNA Ach R blocked

drowsiness, sedation and memory loss

20

dopamine synthesis

presynatpic terminal form tyrosine

21

storage dopamine

loaded by vesciular monoamine transporter

22

inactivaiton dopamine

reuptake into presynaptic cells mediated by dopamine transporter DAT(majoirty) and plasma membrane monoamine transpoters

23

dopamine R

D1-5

24

D1 R activation causes what

increase cAMP
stimulatory

25

D2 R activation

inhibitory
postsynaptic increase K decrease cAMP
presynaptic dec Ca

26

where are the cell bodies of dopaminergic neurons

midbrain with substantia nigra pars compacta and in hypothalamus

27

what do midbrain dopaminergic neurons influence

motor control, emotion, motivation and cognitive processes like memory

28

Parkinsons

DA neurons in striatum degenerate

29

shizophrenia/psychosis

increased dopaminergic activity

30

what is used to Tx shizophrenia

D2 R antagonists

31

how does cocaine effect dopamine

DA uptake blockate

32

amphetamines change dopamine how

increase dopamine release

33

reward pathway

ventral tegmental dopamine pathways that mediate subjective effects of drugs of abuse

34

norepi synthesis

NE granules from dopamine by dopamine beta hyroxylase

35

storage NE

in grnaules where made

36

inactivation NE

reuptake mediated by norepri transporter

37

what R noes norepi work on

metabotropic
alpha 1 2
beta 1,2,3

38

a1 stimulation by NE

excitatory
dec K, increase IP3 and DAG

39

agonist for alpha 1 R

phenyleprhine

40

antagonist for alpha 1 R

phentolamine, prasozin

41

activation alpha 2 R

inhibitory
postsynaptic inc K dec cAMP
pre: dec Ca

42

agonist alpha 2

clonidine

43

antagonist to alpha2

yohimbine

44

activation beta 1

exctitatory
dec K increase cAMP

45

agonist beta 1

isoproterenol

46

antagonist beta1

propranolol

47

activation beta 2

excitatory
increase cAMP

48

agonist beta 2

albtuerol

49

antaonist beta 2

butoxamine

50

where are cell bodies for noradrenergic neurons

locus ceruleus

51

what do NE neurons modulate

sleep, wakefulness, attention and feeding behaviors

52

NE has what role in mood disorders

depression