Path I Flashcards

1
Q

what is the timecourse for vascular neuro path

A

sec to minutes

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2
Q

what is timecourse for abscess in neuro

A

hours days

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3
Q

what is timecourse for neoplasms in neuro

A

weeks to months

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4
Q

what is timecourse for degenerative disease

A

months years decades

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5
Q

how does neuro MS present

A

relapse and remission over years

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6
Q

toxic causes for neuro path

A

drugs endocrine, electrolytes, nutritional, organ failure

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7
Q

acute diffuse symmetrical sx in neuro is usually what

A

viral, metabolic or toxic

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8
Q

pain in neuro are usually what srtuctures

A

meninges and vessels have pain fibers

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9
Q

gray matter pathophys characteristic

A

cognitive loss, movement disorders or seizures

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10
Q

white matter presentation

A

motor sensory visual or cerebellar

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11
Q

progressive symmetric loss is usually

A

metabolic or degenerative

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12
Q

head and limb defects on opposite sides is usually what location lesion

A

brainstem

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13
Q

what imaging is used in neuroradiology

A

CT MRI and angiography

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14
Q

What imaging is prefferedin emergencie neuro situations

A

CT because fast and can see fresh blood and skull fractures

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15
Q

what color will the subcut fat of scalp be

A

near black

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16
Q

what color is CSF on CT

A

black- hypodense

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17
Q

what is “isodense” on CT

A

fat from myelin

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18
Q

what is hyeprdense on CT

A

bone and fresh blood

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19
Q

what will isodense or hypodense blood show

A

isodense it has been 1 week

hypodense it has been 2-3 weeks

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20
Q

lens shaped bleed in cranium does not cross suture lines

A

epidural

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21
Q

crescent shaped, crosses suture lines is what type bleed

22
Q

common area and cause of intraparenchymal/intracerebral hemorrhage

A

basal ganglia

HTN

23
Q

pneumonic for how to read CT

A

Blood Can Be Very Bad

Blood, Cisterna, Brain, Ventricles, Bones

24
Q

what is a cistern

A

opening in subarachnoid space of brain from separation of arachnoid from pia mater

25
4 key cisterns
circummesencephalic, suprasellar, quadrigeminal, sylvian
26
2 main questions when evaluating cisterns
blood and if cisterns are open
27
when exammining brain on CT
symmetry grey white differentiation shift hyper/hypodensity
28
earlies sign of CVA on CT
loss of gey-white interface on CT | compare side to side
29
What is a shift in brain
falx is not on midline
30
areas of tumor ischemia appear what color on CT
black, hypodense
31
what implies open fracture
epidural bleed with pocket of air!!
32
if temporal horns dilated
hydrocephalus
33
what is ring enhancing lesion
mass with VESSEL proliferation
34
what can cause a ring enhancng lesion
abscess glioblastoma metastasis
35
What are types of neuroangiography
doppler US spiral CT angiography MRA
36
imaging of choice to detect vessel narrowing, thrombosis and dissection
MRA
37
what maye myelin in CNS
oligodendrocytes
38
What is neuropil
the pink area on H&E stain | it represents axons, dendrites and extracellular fluid
39
what stain can you see axons and dendrites
silver stain | "bielshowsky"
40
what are the layers of the neoCx
``` molecular external granular external pyramidal internal granular internal pyramidal multiform ```
41
what are the parts of the cerebral Cx
archiCx paleoCx neoCx
42
role of archiCx
connects limbic system to the Cx
43
role of paleoCx
linked to olfactory Sx
44
Nissl body
large granules of RER with rosettes of free ribosomes sites of protein synthesis foynd in neurons
45
what is central chromatolysis
when the nissl bodies all migrate to periphery | 1st change after an axon is severed
46
anoxic neurons
injured neurons that shrink and become eosinosphilic from dense mitochondria nuclei turn pyknotic
47
what conditions cause irreversible neuronal injury
hypoxia ischemia and hypoglycemia
48
GFAP + stain
astrocytes
49
what is the glia limitans
thick layer of interdigitatin astrocytes on surface of Cx
50
what forms scar tissue in CNS
astrocytes
51
What are alzheimer type II astrocytes
in acute metabolic disorders astrocytes enlarge nuclei large and clear(vacuoles) with H&E stain