Flashcards in Pharm1E1 Cholinergic Antagonists & NM Drugs Deck (57)
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1
atropine has high affinity for ? receptors and little to no affinity for ?
muscarinic- NONSELECTIVE for M1-M5
nicotine>> little to no effect at ganglia
2
tissues most sensitive to atropine? 3
salivary
bronchial
sweat
3
? is 5 times more selective for M1 over ? receptors
pirenzepine
M2
4
common s/e of musc. ant
dry mouth
5
sites with little cholinergic control i.e. ? wont respond significantly
blood vessels
6
antimuscarinics that enter the CNS can cause ? and ?
drowsiness
amnesia
7
treats motion sickness; s/e include dry mouth & ?
scopolamine
sedation
8
high doses of atropine results in?
tachycardia
9
low doses of atropine.. initially causes ? b/c
the ? receptors aka ? on the ? terminals are blocked; these receptors normally reduce synaptic release of ? so when they are blocked more Ach is released, resulting in bradycardia
bradycardia
presynaptic muscarinic
autoreceptors
vagal nerve
Ach
10
blockade of atrial muscle M2 receptors = no clinical significance except in ? or ?
atrial flutter, fibrillation
11
overall antimuscarinic effects on heart not dramatic: ? and little to no change in ?
tachycardia, blood pressure
12
atropine - respiratory - bronchodilation and reduction in?
bronchial secretions
13
in RS primary use is ? and ?
reduce secretions and prevent laryngospasm (inhalation anesthesia)
14
elevation of body temperature in infants aka?
atropine fever
15
antimuscarinics reduce ? but have little effect on ?
tremor, bradykinesia
16
drugs for PD? 3
cogentin
artane
norflex
aka CAN
17
topical app- eye
aids in measurement of ? and facilitates ?
refractive error
eye exam of retina
18
antimuscarinics for the eye? PACS TH
paremyd- combo of antimusc & sym-mimetic
atropine
cyclopentoate
scopolamine
tropicamide
homatropine
19
? is the longest acting on the eye
atropine
20
? is best for eye exams; shortest acting
tropicamide
21
respiratory- inhibit airway secretions & cause bronchodilation (5)
atropine
hyoscyamine
ipratropium
combivent
tiotropium
22
best for asthma?
combivent- activates B2!
23
1st line for COPD
ipratropium
24
GI- peptic ulcer 3
rarely used- PPIs more common
atropine
anaSPAZ
rubinol
25
Diarrhea drug- additive to ? to discourage abuse
lomotil, opioid
26
antispasmodics - 2
treats IBS & spastic colon
atropine
bentyl
27
only one for heart?
low dose =?
high dose=?
atropine
bradycardia (presynaptic inhibition)
tachycardia (may extend an infarct)
28
atropine can reverse ? in the heart and ? attacks aka ? can be blocked
bradycardia
vaso-vagal, syncope
29
GU- relieve urinary urgency/incontinence
s/e include ? and ?
name 6
ditropan XL
detrol LA
sanctura
toviaz
enablex
vesicare
**last two are M3 selective-detrusor muscle- overactive bladder
30
