Flashcards in Pharm1E1 Cholinergic Antagonists & NM Drugs Deck (57)
atropine has high affinity for ? receptors and little to no affinity for ?
muscarinic- NONSELECTIVE for M1-M5
nicotine>> little to no effect at ganglia
tissues most sensitive to atropine? 3
? is 5 times more selective for M1 over ? receptors
common s/e of musc. ant
sites with little cholinergic control i.e. ? wont respond significantly
antimuscarinics that enter the CNS can cause ? and ?
treats motion sickness; s/e include dry mouth & ?
high doses of atropine results in?
low doses of atropine.. initially causes ? b/c
the ? receptors aka ? on the ? terminals are blocked; these receptors normally reduce synaptic release of ? so when they are blocked more Ach is released, resulting in bradycardia
blockade of atrial muscle M2 receptors = no clinical significance except in ? or ?
atrial flutter, fibrillation
overall antimuscarinic effects on heart not dramatic: ? and little to no change in ?
tachycardia, blood pressure
atropine - respiratory - bronchodilation and reduction in?
in RS primary use is ? and ?
reduce secretions and prevent laryngospasm (inhalation anesthesia)
elevation of body temperature in infants aka?
antimuscarinics reduce ? but have little effect on ?
drugs for PD? 3
topical app- eye
aids in measurement of ? and facilitates ?
eye exam of retina
antimuscarinics for the eye? PACS TH
paremyd- combo of antimusc & sym-mimetic
? is the longest acting on the eye
? is best for eye exams; shortest acting
respiratory- inhibit airway secretions & cause bronchodilation (5)
best for asthma?
combivent- activates B2!
1st line for COPD
GI- peptic ulcer 3
rarely used- PPIs more common
Diarrhea drug- additive to ? to discourage abuse
antispasmodics - 2
treats IBS & spastic colon
only one for heart?
low dose =?
bradycardia (presynaptic inhibition)
tachycardia (may extend an infarct)
atropine can reverse ? in the heart and ? attacks aka ? can be blocked
GU- relieve urinary urgency/incontinence
s/e include ? and ?
**last two are M3 selective-detrusor muscle- overactive bladder