Pharm2Spectrum/PCN Flashcards Preview

Pharmacology > Pharm2Spectrum/PCN > Flashcards

Flashcards in Pharm2Spectrum/PCN Deck (37):
1

probenecid blocks tubular secretion/prolongs activity of ?

PCN, cephs

2

? and ? are resistant to cephs

listeria, c. diff

3

used synergistically with a/g (gentamicin)?

PCN, cephs

4

ceph- G1?

G + cocci, PEcK

5

ceph- G2?
subclass?

G + cocci, PEcK HiM
anaerobes (B. fragilis, C. perfringens)

6

ceph- G3?

G + cocci, PEcK HiM &
Neisseria g., Serratia, Citrobacter, Providencia

7

ceph- G4?

similar to G3 but better for Enterobacter
P. aeroginosa

8

ceph- G5?

similar to G2 plus Enterobacter&Citrobacter
MRSA, VRSA, VISA, VREF (enterococcus faecalis)

9

carbapenems
most ? beta lactams
resistant to most?

broad
beta lactamases

10

bacitracin spectrum of activity?

G + cocci and bacilli

11

vancomycin?

G + only

12

aztreonam (monobactam)
esp?
NO?

G - bacilli
G + *****

13

polymixin B bacteriocidal for ?

gram - bacilli (no G + activity)

14

sulfonamides bacteriostatic against ?

G + & -

15

FQ- G2?

G - activity

16

FQ- G3 & 4?

G - AND + (b/c of iso IV)

17

TCN- broadest spectrum Abx! ....

aerobic AND anaerobic G- and G+

18

A/G ?

severe infix from G- bacilli

19

FQ - resistance?

Beta lactamases

20

macrolides do not ? aka can't tx?

BBB, meningitis

21

macrocodes are ?/? in low concentrations BUT ?/? in high !

bacteriostatic/P.O.
bacteriocidal/IV

22

? is resistant to all macrolides
Tx with?

strep pneumo
telithromycin

23

drug interactions (4)

erythro
clarithro
chloramphenicol
all of the -azoles

24

amino glycosides are synergistic with all ? and ?

beta lactams, vancomycin

25

amphotericin b w/ ? for ?

fluconazole, coccidiodomycosis meningitis

26

Pen G activity

gram pos: cocci, meningococci, bacilli, anaerobes
spirochetes (DOC chlam, lymes)
little gram neg activity

27

Pen V activity
more stable than ?
Tx ? infx, streptococci, ? pneumococci

Pen G
oropharyngeal, pcn-SENSITIVE

28

extended spectrum PCNs

pen G & gram neg (HEMP) H flu, E coli, Morax, Proteus

29

Ticercillin & piperacillin- only pcn?
(otherwise same as amos)

active against pseudomonas, klebsiella, bacteroides

30

MRSA develops from resistance via?
so does ? and ?

modification of PBPs
pen-resistant pneumococci, enterococci

31

beta lacatamase inhibitors are added to drugs to be able to treat ?

penicillinase producing organisms

32

food decreases absorption in all PCN except?

amox

33

Weil's Dz (?) and Actinomycosis are tx by?

(leptospira) Pen G

34

? also treat salmonella, shigella, campylobacter

ampicillin (gastroenteritis)

35

Amox good for ? but bad for ? bc 90% gets absorbed
Ampicillin 1st line for ? and good for ? b/c 50% gets absorbed

H pylori, GI tract infxn

Listeria meningitis (G+ meningitis!), Gastroenteritis

36

make beta lactamase (2)

staphylococcus
enterobacter

37

make penicillinase (6)
steph klub makes HEMP!
(formerly

staph
kleb
haemophilus
e coli
moraxella
pasteurella