Flashcards in Pharm2Spectrum/PCN Deck (37):
1
probenecid blocks tubular secretion/prolongs activity of ?
PCN, cephs
2
? and ? are resistant to cephs
listeria, c. diff
3
used synergistically with a/g (gentamicin)?
PCN, cephs
4
ceph- G1?
G + cocci, PEcK
5
ceph- G2?
subclass?
G + cocci, PEcK HiM
anaerobes (B. fragilis, C. perfringens)
6
ceph- G3?
G + cocci, PEcK HiM &
Neisseria g., Serratia, Citrobacter, Providencia
7
ceph- G4?
similar to G3 but better for Enterobacter
P. aeroginosa
8
ceph- G5?
similar to G2 plus Enterobacter&Citrobacter
MRSA, VRSA, VISA, VREF (enterococcus faecalis)
9
carbapenems
most ? beta lactams
resistant to most?
broad
beta lactamases
10
bacitracin spectrum of activity?
G + cocci and bacilli
11
vancomycin?
G + only
12
aztreonam (monobactam)
esp?
NO?
G - bacilli
G + *****
13
polymixin B bacteriocidal for ?
gram - bacilli (no G + activity)
14
sulfonamides bacteriostatic against ?
G + & -
15
FQ- G2?
G - activity
16
FQ- G3 & 4?
G - AND + (b/c of iso IV)
17
TCN- broadest spectrum Abx! ....
aerobic AND anaerobic G- and G+
18
A/G ?
severe infix from G- bacilli
19
FQ - resistance?
Beta lactamases
20
macrolides do not ? aka can't tx?
BBB, meningitis
21
macrocodes are ?/? in low concentrations BUT ?/? in high !
bacteriostatic/P.O.
bacteriocidal/IV
22
? is resistant to all macrolides
Tx with?
strep pneumo
telithromycin
23
drug interactions (4)
erythro
clarithro
chloramphenicol
all of the -azoles
24
amino glycosides are synergistic with all ? and ?
beta lactams, vancomycin
25
amphotericin b w/ ? for ?
fluconazole, coccidiodomycosis meningitis
26
Pen G activity
gram pos: cocci, meningococci, bacilli, anaerobes
spirochetes (DOC chlam, lymes)
little gram neg activity
27
Pen V activity
more stable than ?
Tx ? infx, streptococci, ? pneumococci
Pen G
oropharyngeal, pcn-SENSITIVE
28
extended spectrum PCNs
pen G & gram neg (HEMP) H flu, E coli, Morax, Proteus
29
Ticercillin & piperacillin- only pcn?
(otherwise same as amos)
active against pseudomonas, klebsiella, bacteroides
30
MRSA develops from resistance via?
so does ? and ?
modification of PBPs
pen-resistant pneumococci, enterococci
31
beta lacatamase inhibitors are added to drugs to be able to treat ?
penicillinase producing organisms
32
food decreases absorption in all PCN except?
amox
33
Weil's Dz (?) and Actinomycosis are tx by?
(leptospira) Pen G
34
? also treat salmonella, shigella, campylobacter
ampicillin (gastroenteritis)
35
Amox good for ? but bad for ? bc 90% gets absorbed
Ampicillin 1st line for ? and good for ? b/c 50% gets absorbed
H pylori, GI tract infxn
Listeria meningitis (G+ meningitis!), Gastroenteritis
36
make beta lactamase (2)
staphylococcus
enterobacter
37