PharmExam4- composition/MOA Flashcards Preview

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Flashcards in PharmExam4- composition/MOA Deck (45):
1

active metabolite Nortriptiline

amtriptiline

2

most potent, selective inhibitor of NE reuptake

imipramine

3

most selective for inhibition of serotonin reuptake

clomipramine

4

unique: NO action on transporters; EXTREMELY strong affinity for histamine

trimipramine

5

D2 receptor antagonist; mixed antidepressant and neuroleptic

amoxapine

6

unique- binds NE but HIGHER affinity for dopa

buproprion

7

antagonist at 5HT2/3 and H1

mirtazepine

8

block sero and NE?

SNRIs

9

block 5HT2a and 5HT1a at high doses

trazadone

10

blocks 5HT2

nefazodone

11

serotonin reuptake blockade, potent inhibitor of P450

SSRIs

12

substitute for sodium

lithium

13

blocks turnover and release of dopa and NE but INCREASED SEROTONIN

lithium

14

depletes phosphatidylinositol-4,5 biphosphate (PIP2)

lithium

15

reversibly inhibits nerve conduction .. binds and inhibits opening of sodium channels on INTRACELLULAR side

local anesth.

16

prototype, competitive antagonist at nicotinic receptor

curarine

17

prevents depolarization by Ach (hypotension from histamine release)

d-Tubocurarine

18

laudanosine metabolite, histamine release

atracurium

19

NO laudanosine, no histamine release, more potent

CISatracurium

20

non depolarizing steroid that blocks muscarinic receptors (part of triple cocktail lethal injxn)

pancuronium

21

non depolarizing steroid that has slight antimusc effects, for ppl w/ CV probs

rocuronium

22

nicotinic agonist- fasiculations followed by desensitized

succinylcholine

23

alpha 2 agonist, spasmolytic

tizanidine

24

blocks ryanodine receptor in Ca release channels

dantrolene

25

blocks Ach in NMJ

botox

26

NET & SERT inhibitor, NMDA antagonist

methadone

27

quick onset, short DOA, faster than morphine but slower than heroine, many options?

fentanyl (i.e. transmucosal for cancer pain)

28

anticholinergic so NO BRADY or CONSTIPATION

meperidine

29

prodrug that undergoes demethylation to become activated

codeine

30

weak inhibitor of NET and SERT reuptake and u agonist

tramadol

31

kappa agonist, mu antagonist

nalbuphine

32

MU partial agonist, kappa antagonist

buprenorphine

33

at higher doses also zero order kinetics

aspirin

34

reduces prostaglandin formation, does NOT affect leukotrienes

aspirin

35

TNF alpha and NO synthesis inhibitor

flubiprofen

36

inhibits cyclooxygenase AND lipoxygenase activity

ketoprofen

37

extremely potent- ONLY to reach a narcotic analgesic level

ketoprofen

38

not good at inhibiting inflammation, mostly parenteral, almost as good as morphine

ketorolac

39

only NON ACID NSAID, ketone prodrug

nabumetone

40

pyrroleacetic acid

tolmetin

41

binds to 5HT1B and 1D- agonists; cause vasoconstriction

triptans

42

5HT1B and D agonists; antidote is nitroprusside

ergot alkaloids

43

NONpurine xanthine oxidase inhibitor

febuxostat

44

inhibits organic anion transporter so that you can't reabsorb uric acid

probenecid

45

inhibits nociceptor transmission in dorsal horn

tizanidine