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Flashcards in Adrenergic Agonists Deck (45):
1

? is the parent compound from which all catecholamines and sympathomimetic drugs are derived

phenylethylamine

2

increased size of alkyl substitutions increase ? activity

B-receptor

3

removal of one or both of the ? on the benzene ring reduces the activity of the enzyme and increases the bioavailability and DOA of the drug

hydroxyl groups

4

alpha adrenergic increase arterial resistance in ? and ?

skin
splanchnic vessels

5

catecholamine are excluded and enter only with ?

high rates of infusion

6

non-catecholamines i.e. ? or ? readily enter the CNS

amphetamine, methylphenidate

7

activation of alpha 2 receptors in the ? decreases sympathetic outflow and causes ?

brainstem
hypotension

8

epinephrine acts on ? receptors

both alpha, both beta

9

epi treats ? by increaseing aqueous humor ? and decreasing its ?

OPEN angle GLC, outflow, production

10

hypovolemia, cardiac insufficiency, altered vascular resistance?

three major mechanisms responsible for shock

11

? is preferred for NON-anaphylactic shock- dilates renal vasculature

dopamine

12

only use of NE is to ? in an ? state
-metabolized rapidly by ? and ?- very short 1/2 life

increase BP, acute hypotensive
MAO, COMT

13

NE has no effect on ?

B2

14

Isoproterenol only acts on ?

beta receptors

15

potent vasoconstrictor and rapid IV can lead to reverse HR due to reflex effect?

Epi

16

use isoproterenol for acute ? and emergency ?; also heart block, torsades pointes

asthma
bradycardia

17

dopamine only give ?

IV

18

dopamine treatment of severe ?

CHF
*also beneficial in septic or cardiogenic shock

19

D1 dopamine receptor- lowers BP in ?
-moderate affinity for ? receptors

severe hypertension
alpha 2

20

full B1 agonist
-short term treatment of ? that may occur after surgery, in CHF, in acute myocardial infarction

dobutamine- LUB DOB ;)
cardiac decompensation

21

alpha one selective agonists? (3)

phenylephrine
ArAmine- off market
proAmAtine

22

resistant to COMT metabolism?
-causes ? and an increase in BP with associated sinus ?
-IV- can be used as a potent ? w/ no direct inotropic or chronotropic effects on the heart
-due to reflex bradycardia- useful in treating ?
-commonly used as a ?
-in eye- effective ? in solutions

phenylephrine
vasoconstriction, bradycardia (reflex)
vasopressor
TACHYcardia
decongestant**
mydriatic

23

treats postural hypotension?

proAmAtine

24

alpha 2 agonists (5)

clonidine
guanafacine
guanabenz
iopidine
alphagan

25

primarily used for hypertension?
also used to Dx phaeochromocytoma

clonidine
*also useful in treating Ca patients, ADHD, nicotine/alcohol withdrawal, vascular HA, diabetic diarrhea, GLC, ulcerative colitis, Tourette's, etc.

26

alpha 2 that decreases IOP by decreasing aqueous humor production?

IOPidine

27

alpha 2 decreases IOP and is used for open angle GLC or ocular htn

alphagan

28

alBUTEROL
terBUTaline
metaprotERenOL
salmeTEROL
formoTEROL

B2 selective agonists (some action at B1 receptors)

29

B2 selective useful for bronchospasm & ? as well as ? due to the uterus relaxation

asthma
preterm labor

30

50 fold more selective than albuterol?

salmeterol

31

used for asthma, bronchospasm, & COPD?

salmeterol

32

B3 agonist- relaxes the detrusor muscle during storage phase increasing ?

mirabegron
bladder capacity

33

indirect acting sympathomimetics main action is to increase synaptic conc of ? and ?

dopamine, NE

34

amphetamin & dextroamphetamine:
1. increased ? release of NT
2. ? transport

vesicular
reverse

35

d-isomer is 3-4 times more potent at stim the CNS than the ? and is available as ? (ADHD)

1-isomer
dexedrine

36

indirect agonists-addiction
CNS- increased ? activity
PNS- increase ? release which can lead to?

dopaminergic
NE
increased systolic&diastolic pressure

37

only CNS effects and no peripheral effects?

ritalin
*this is why it is preferred for ADHD

38

Tx for obesity- decrease food intake but doesn't increase metabolism

amphetamine, dextroamphetamine

39

do NOT give indirect agonists with ? >> massive increases of peripheral NE that could cause a ? and death

MAOI inhibitors
hypertensive crisis

40

all indirect work by stim NE release by ? blocks reuptake of ?

ritalin
dopamine

41

? is more potent than ritalin; d-isomer of ritalin

focalin

42

first orally active sympathomimetic?

ephedrine

43

relief of nasal congestion?
combats fall in BP during epidural anesthesia?
raises Bp/CO/peripheral vasoconstriction?

ephedrine

44

decongestant, stereoisomer of ephedrine, less potent

pseudoephedrine

45

found in high conc in fermented foods like ? and ?
CI in pts takings MAOIs- hypertensive crisis

tyramine