Pharm2- CNS NT

Question 1

selective antagonist & potent convulsant of glycine

Answer 1

strychnine

Question 2

musc receptors

• bind to IP3/DAG?
• bind to Gi?

Answer 2

M1/3/5

M2/4

Question 3

D2 autoreceptor will ? and ?

Answer 3

inhibit dopa syn AND release

Question 4

in the locus ceruleus & lateral segmental system?

Answer 4

NE

Question 5

NE
excitatory?
inhibitory?

Answer 5

a1, b1

a2, b2, b3

Question 6

serotonin mostly inhibitory in the CNS by ?

Answer 6

increasing K conductance

Question 7

serotonin

all rec are GPCR’s except ? is a ?

Answer 7

5HT3, cation channel

Question 8

block 5HT transporter (4)

Answer 8

ecstasy
cocaine
SSRIs
TCAs

Question 9

MAO a/b degrades?

COMT?

Answer 9

NE, DA, 5HT

NE, DA

Question 10

histamine rec
excite?
inhibit?

Answer 10

H1/2

H3

Question 11

excitatory rec on ALL neurons?

Answer 11

AMPA

Question 12

ligand binding and channel closed is termed?

i.e. glutamate will not bind when present in body

Answer 12

desensitization

Question 13

coagonist receptor glutamate/glycine can’t open unless ?

Answer 13

Mg comes out/is pushed out of the way

Question 14

the Mg will only fly out if the cell is ? and will open the NMDA receptor channel completely

Answer 14

depolarized

Question 15

glutamate long term potentiation (LTP) involved in ? and ?

Answer 15

learning, memory

Question 16

inhibit glutamate release, treat seizures?

Answer 16

lamotrigine

Question 17

antagonist at glycine allosteric site of NMDA to treat seizures?

Answer 17

felbamate

Question 18

inhibit transmission in s.c. and brainstem

Answer 18

glycine

Question 19

rate limiting step in synthesis of dopa>NE>Epi?

Answer 19

tyrosine hydroxylase (converts l-tyrosine to l-dihydroxyphenylalanine

Question 20

2 substances not stored?

Answer 20

endocannabinoids

nitrous oxide

Question 21

synthesized from L-arginine; DIRECTLY interacts w/ 2nd messenger system?

Answer 21

nitrous oxide

Question 22

major excitatory?

Answer 22

glutamate

Question 23

major inhibitory? yeng to glutamate-ying?

Answer 23

GABA

Question 24

memory, sensory, motor, coordination, NMJ, ANS/PANS

Answer 24

Ach

Question 25

sleep, sedation, and TEMP REGULATION

Answer 25

histamine

Question 26

motor reg, reinforcement, OLFACTION*, mood, concentration, hormone control

Answer 26

dopamine

Question 27

CNS sensory processing, cerebellar fxn, sleep, mood, learning, memory, anxiety

Answer 27

NE

Question 28

emotional processing, mood, appetite, sleep, pain, hallucinations, reflex

Answer 28

serotonin

Question 29

ANY/ALL addictions: a ton of dopamine dumped into?

Answer 29

nucleus accumbens (also goes into neocortex into higher learning center)

Question 30

all serotonin receptors are ? except 5HT3, which is ?

Answer 30

modulatory, excitatory

Question 31

w/ nitric oxide, there is no?

Answer 31

receptor

Question 32

endocannabinoids are not ? and they move in a ? fashion

Answer 32

stored, retrograde (released from postsynaptic and bind to CB1 on presynaptic)