Pharm2Anti-Myco/Fung Flashcards Preview

Pharmacology > Pharm2Anti-Myco/Fung > Flashcards

Flashcards in Pharm2Anti-Myco/Fung Deck (28):
1

inhibits syn and assembly of mycolic acids into outer layer of mycobac by inhibiting?
toxicity? correct w/?
most serious s/e?

isoniazid (syn derivative of B6)
fatty synthetase II
peripheral neuritis, B6
fatal hepatitis

2

inhibits RNA synthesis (TRANSCRIPTION!)
effect on P450?
if pt taking protease inh, give ?

rifampin
induces!- increased metabolism
rifabutin
*can stain contacts!!

3

1st line TB, (RIPE), enters csf- TB meningitis?

pyrazinamide- bacteriocidal

4

1st line; Tx MAI complex?
s/e ?

ethambutol- bacteriostatic
optic neuritis- decreased VA & color vision disturbances

5

2nd line tb that enters CSF, similar to isoniazid?

ethionamide

6

2nd line tb like a/g, inhibits protein syn, nephro/ototoxicity

capreomycin

7

2nd line tb that inhibits bacterial cw sun & enters CSF

cycloserine (CNS s/e)

8

RDC for leprosy
-inhibits folate biosyn? (sulf. derivative); also Tx PCP
-inhibits DNA fxn & rep, also Tx ?
-bacteriocidal?
-static?

dapsone
clofazimine, MAI complex
cidal- rifampin, dapsone
static- clofzimine

9

s/e methemoglobinemia, erythema nodosum?

dapsone

10

s/e red-brown skin discoloration, eosinophilic enteritis

clofazimine

11

amphotericin B
-SOA?
-given ? only
-can only enter csf w/ ? for cryptoococcus men.
-give ? by itself for ? do to coccidiodes

tx all 7 fungal infx, 1st line for life-threatening
IV
flucytosine
intrathecally**, fungal meningitis

12

tx chromoblastomycosis?

flucytosine

13

give PO & inhibits DNA & RNA sun by blocking thymidylate synthase?

flucytosine

14

1st line for candidemia, mucosal candidiasis, coccidiomycosis
*given ORALLY for ??*
prophy ? in AIDS pts

fluconazole
fungal meningitis***
cryptococcal meningitis

15

DOC/1st line for paracoccidiodomycoses, histoplasmosis, blastomycosis; NO CSF
s/e ??

itraconazole
minerlcorticoid-like s/e

16

first line for aspergillosis, PO or IV

voriconazole; s/e V for visual disturbances

17

first line for prophy aspergillus and candida in I/C

posaconazole

18

echinocandins - 'fungin-
MOA?
MUST be given ?
prophy candida in BM transplant?
aspergillus salvage tx?
main s/e?
toxicity?

inhibit cell wall by inh B-glucan synthase
IV
micafungin
caspofungin
myelosuppression
vancomycin-like

19

inhibits microtubule assembly?
effective against dermatophytes, PO
distributes to ?
? diet promotes absorption

griseofulvin
hair, skin, nails
high-fat

20

also effective against tine, PO and topical, inhibits erg synthesis?

terbinafine

21

same MOA as amp B? (2)

nystatin, natamycin

22

like amph B, nystatin not ? when given orally

absorbed

23

ophthalmic antifungal suspension for fungal keratitis, blepharitis, conjunctivitis?

natamycin

24

all azoles (INCLUDE TOLNAFTATE) inhibit ? and have ?

erg syn, drug int

25

s/e in all anti-fungals?

hepatic dysfxn

26

don't use keto w/ ?

amph B- will inn its effects like a static antagonizing a cidal

27

for candida use ? w/ keto

flucytosine

28

remaining -azoles are only ?

topical (bc of toxicity)