Flashcards in Pharm2Anti-Myco/Fung Deck (28):
1
inhibits syn and assembly of mycolic acids into outer layer of mycobac by inhibiting?
toxicity? correct w/?
most serious s/e?
isoniazid (syn derivative of B6)
fatty synthetase II
peripheral neuritis, B6
fatal hepatitis
2
inhibits RNA synthesis (TRANSCRIPTION!)
effect on P450?
if pt taking protease inh, give ?
rifampin
induces!- increased metabolism
rifabutin
*can stain contacts!!
3
1st line TB, (RIPE), enters csf- TB meningitis?
pyrazinamide- bacteriocidal
4
1st line; Tx MAI complex?
s/e ?
ethambutol- bacteriostatic
optic neuritis- decreased VA & color vision disturbances
5
2nd line tb that enters CSF, similar to isoniazid?
ethionamide
6
2nd line tb like a/g, inhibits protein syn, nephro/ototoxicity
capreomycin
7
2nd line tb that inhibits bacterial cw sun & enters CSF
cycloserine (CNS s/e)
8
RDC for leprosy
-inhibits folate biosyn? (sulf. derivative); also Tx PCP
-inhibits DNA fxn & rep, also Tx ?
-bacteriocidal?
-static?
dapsone
clofazimine, MAI complex
cidal- rifampin, dapsone
static- clofzimine
9
s/e methemoglobinemia, erythema nodosum?
dapsone
10
s/e red-brown skin discoloration, eosinophilic enteritis
clofazimine
11
amphotericin B
-SOA?
-given ? only
-can only enter csf w/ ? for cryptoococcus men.
-give ? by itself for ? do to coccidiodes
tx all 7 fungal infx, 1st line for life-threatening
IV
flucytosine
intrathecally**, fungal meningitis
12
tx chromoblastomycosis?
flucytosine
13
give PO & inhibits DNA & RNA sun by blocking thymidylate synthase?
flucytosine
14
1st line for candidemia, mucosal candidiasis, coccidiomycosis
*given ORALLY for ??*
prophy ? in AIDS pts
fluconazole
fungal meningitis***
cryptococcal meningitis
15
DOC/1st line for paracoccidiodomycoses, histoplasmosis, blastomycosis; NO CSF
s/e ??
itraconazole
minerlcorticoid-like s/e
16
first line for aspergillosis, PO or IV
voriconazole; s/e V for visual disturbances
17
first line for prophy aspergillus and candida in I/C
posaconazole
18
echinocandins - 'fungin-
MOA?
MUST be given ?
prophy candida in BM transplant?
aspergillus salvage tx?
main s/e?
toxicity?
inhibit cell wall by inh B-glucan synthase
IV
micafungin
caspofungin
myelosuppression
vancomycin-like
19
inhibits microtubule assembly?
effective against dermatophytes, PO
distributes to ?
? diet promotes absorption
griseofulvin
hair, skin, nails
high-fat
20
also effective against tine, PO and topical, inhibits erg synthesis?
terbinafine
21
same MOA as amp B? (2)
nystatin, natamycin
22
like amph B, nystatin not ? when given orally
absorbed
23
ophthalmic antifungal suspension for fungal keratitis, blepharitis, conjunctivitis?
natamycin
24
all azoles (INCLUDE TOLNAFTATE) inhibit ? and have ?
erg syn, drug int
25
s/e in all anti-fungals?
hepatic dysfxn
26
don't use keto w/ ?
amph B- will inn its effects like a static antagonizing a cidal
27
for candida use ? w/ keto
flucytosine
28