Pharm2Anti-Viral/Protozoa Flashcards Preview

Pharmacology > Pharm2Anti-Viral/Protozoa > Flashcards

Flashcards in Pharm2Anti-Viral/Protozoa Deck (38):
1

inhibit viral neuraminidase and block viral rep?

Oseltamivir- PO & Zanamivir- inhalation
both CI in neonates
zanmivir CI in COPD & asthma

2

inhibits viral mRNA syn/transcription
virazole given by inhalation for serious RSV infix
CI in ?

ribavirin
pregnancy

3

monoclonal ab against RSV- prophy in high risk peds pts for LRT Dz

palivizumab - IM

4

DOC for HSV encephalitis, zoster?
also tx HSV 1,2, labialis, CMV prophy

acyclovir- PO/IV!!

5

ORAL for genital herpes, herpes labialis, zoster

valacyclovir

6

HSV keratitis & keratoconjunctivitis

trifluridine aka virOPTIC

7

topical tx of herpes labialis

penciclovir

8

prodrug of pen; ORALLY for zoster

famciclovir

9

Docosanol?

OTC for herpes labialis

10

TREATS CMV retinitis and CMV prophy
s/e- myelosuppression

ganciclovir

11

IV for CMV retinitis?

cidofovir
foscarnet (only one not phosphorylated- pyrophosphate derivative)

12

foscarnet s/e?

electrolyte disturbances- hypoCa&K

13

NRTIs MOA similar to ?
-nucleosides phophorylated into ? by ? in the virus and then in the host
*only activated in cells infected with virus
-converted into ? in cells and inhibit ?
-s/e? (3)

acyclovir
nucleotides, protein kinases
triphosphate, RT
myelosuppression, peripheral neuropathies, hepatomegaly w/ steatosis

14

directly & non competitively inhibit RT by disrupting RT catalytic site? (aren't nucleosides so DONT need to be activated)

NNRTIs
neVIRapine, delaVIRdine, efaVIRenz, etraVIRine

15

w/ fusion inh (enfuviritide- sQ), increased risk of ?
bind to viral envelop glycoprotein and prevent HIV from entering ?

pneumonia
WBCs

16

for Hep B virus?
if resistant?

lamivudine (epivir, epivir-HBV)
adefovir, entacavir

17

NRTI that converts AZT to AZT triphosphate & inhibits DNA syn via inh RT
>>>crosses BBB***
>>>s/e worst ? of all NRTIs

zidovudine
bone marrow toxicity

18

didanosine & lamivudine s/e?

pancreatitis

19

zidovudine & lamivudine called ?

combivir

20

inhibit cleavage of polypeptide precursors that generate proteins/enzymes- block rep
-commonly used with ?

protease inh
zidovudine, lamivudine

21

interferes w/ parasites microtubule fxn, inhibiting glucose uptake; tx ALL 7 nematodes

albendazole

22

inh depolarization- activation of nicotinic receptors-paralysis; pinworm/roundworm/hookworm

pyrantel pamoate

23

activates GABA receptors (inhibitory)- paralysis
-DOC for ?
also treats? (2)

ivermectin
onchocerciasis
filariasis, head lice (SKLICE)

24

Trematodes & cestodes tx by?

praziquantel

25

treats blood and liver fluke by increasing ca permeability- paralysis of worm

trematodes- praziquantel

26

tx taenia saginata/solium, cysticercosis but ? is DOC and CANT tx ocular bc paralysis of worm in eye may lead to blindness!

cestodes- praziquantel
albendazole

27

mixed amebicide, accepts electrons leading to cytotoxic free radicals
-DOC for E histolytica, giardia, bac vaginosis; also tx anaerobic infx i.e. c diff, bacteroides

metronidazole (crosses BBB- meningitis)

28

luminal amebicides?
systemic?

parmomycin, iodoquinol
chloroquine- amebic liver abscess

29

radical cure for milaria, tissue schizonticide that eradicates 1 and 2 EXOerythrocytic form of P vivax and ovale

primaquine; s/e: hemolytic anemia

30

BLOOD schizonticide that only eradicates erythrocytic form; CLINICAL cure (alleviates Sx)
-s/e (2)?

chloroquine
in combo w/ metro and iodoquinol for prophy/tx of amebic liver abscess
visual disturbances, ototoxicity

31

used for chloroquine-resistant malarial strains?
s/e?

quinine
cinchonism

32

blood schizonticide for MDR P. falciparum malaria

mefloquine; s/e- hallucinations

33

blood schizonticide- folate antagonist
P falciparum, P malariae, Toxoplasma gondii

pyrimethamine

34

blood AND tissue schizonticide
Atovaquone & Proguanil
syn inn of pyrimidine biosynthesis in malaria
prophy and tx of MDR strains (chloroquine AND quinine)

MALarone

35

trypanosomiasis- brucei gambiense/rhodiense
-only to cross BBB?
-tx and prophy; also tx and prophy for PCP?
-cytotoxic radicals; only one for Chagas' (cruzi)?
-prophy and early tx; also tx onchocerciasis?

melarsoprol- IV
pentamidine isethionate- aerosol or IM
nifurtimox- PO
suramin- IV, a/e: shock

36

sodium stibogluconate for ?

leishmaniasis; s/e: cardiac arrhythmias

37

amebicide that induces cell membrane leakage?

paromomycin

38

s/e of blood schizonticide and sporontocide - megaloblastic anemia - reverse w/ leucovorin ?

pyrimethamine