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Flashcards in Pharm2CWI Deck (12):
1

carbapenems
empiric tx - 2

imipenem
meropenem

2

carbapenems resistant to most?

beta lactamases

3

penem that tx various nosocomial infx from serrate, actinobacter?

imipenem (w/ cilastatin b/c it is hydrolyzed by renal dehydropeptidase to nephrotoxic metabolite)

4

penem that may cause seizures?

imipenem (broadest b lactam on market)

5

monobactam name?
resistant to?
no ? activity, only ?
UTIs, RTIs, nosocomial

Aztreonam
b-lactamases
G + activity, G - aerobic

6

Bacitracin - CWI
SOA?
topical ONLY, systemic can lead to ?
skin, ocular w/ ?

gram pos
nephrotoxicity
neomycin, polymixin B

7

vancomycin
SOA?
w/ ? for synergism
DOC/1st line for ? (3)
*only oral for c diff; rest are slow IV b/c of flushing, shock, etc.; can also have ??

Gram pos
a/g
tetanus, pen-resistant s. pneumo, MRSA
ototoxicity

8

gramcidin- membrane disruptor
only TOPICAL
SOA?
s/e?
replaces bacitracin in combo with ? and ? for ocular infix?

G + cocci, bacilli
hemolysis
polymixin B, neosporin

9

daptomycin- depolarizes membrane potential
SOA?
is considered a cyclic ?
MDRSP VRSA MRSA VRE endocarditis bacteremia

only G+
lipopeptide

10

fosfomycin- PO
SINGLE dose to treat?
safe & used in ?
resistance from?
commonly UTI in female

acute cystitis
PREGNANCY***
decreased permeability

11

2nd line TB; bacterioSTATIC
s/e: ? toxicity, ? neuropathies

Cycloserine
CNS- CROSSES BBB, peripheral

12

Polymixin B- bacteriocidal for ?
usually topical, opthalmic
? ? and ? are resistant
s/e- nephro/neurotoxicity
Tx ? corneal ulcers and external otitis media
cationic detergents

G neg rods only!
G+, proteus, neisseria
pseudomonal