Flashcards in Pharm2CWI Deck (12):
1
carbapenems
empiric tx - 2
imipenem
meropenem
2
carbapenems resistant to most?
beta lactamases
3
penem that tx various nosocomial infx from serrate, actinobacter?
imipenem (w/ cilastatin b/c it is hydrolyzed by renal dehydropeptidase to nephrotoxic metabolite)
4
penem that may cause seizures?
imipenem (broadest b lactam on market)
5
monobactam name?
resistant to?
no ? activity, only ?
UTIs, RTIs, nosocomial
Aztreonam
b-lactamases
G + activity, G - aerobic
6
Bacitracin - CWI
SOA?
topical ONLY, systemic can lead to ?
skin, ocular w/ ?
gram pos
nephrotoxicity
neomycin, polymixin B
7
vancomycin
SOA?
w/ ? for synergism
DOC/1st line for ? (3)
*only oral for c diff; rest are slow IV b/c of flushing, shock, etc.; can also have ??
Gram pos
a/g
tetanus, pen-resistant s. pneumo, MRSA
ototoxicity
8
gramcidin- membrane disruptor
only TOPICAL
SOA?
s/e?
replaces bacitracin in combo with ? and ? for ocular infix?
G + cocci, bacilli
hemolysis
polymixin B, neosporin
9
daptomycin- depolarizes membrane potential
SOA?
is considered a cyclic ?
MDRSP VRSA MRSA VRE endocarditis bacteremia
only G+
lipopeptide
10
fosfomycin- PO
SINGLE dose to treat?
safe & used in ?
resistance from?
commonly UTI in female
acute cystitis
PREGNANCY***
decreased permeability
11
2nd line TB; bacterioSTATIC
s/e: ? toxicity, ? neuropathies
Cycloserine
CNS- CROSSES BBB, peripheral
12