Flashcards in Pharm2Sulf/FQ Deck (20):
1
sulf:
SOA:
s/e: ?uria, hypersensitivity, ? in newborns, drug potentiation from ?
G+&-
crystal, kernicterus, albumin displacement
2
aka pediazole; otitis media (H flu) in peds
erythro (ESP) & sulfasoxazole
3
UTIs, RTIs, gastroenteritis, PCP***
sulfamethoxazole-trimethroprim
4
toxoplasmosis; give w/
sulfadiazine & pyramethamine; folinic acid
5
broken down to 5-aminosalicylate; Tx IBD?
sulfasalazine (PO or suppository)
6
topical for eye and skin infx, acne
sulfacetamide
7
Tx burns, prevent sepsis
silver sulfadiazine
8
-much more potent than sulfa's, analog of dihydrofolic acid; UTIs & bacterial prostatitis?
-inhibits ? (second step in FA sun
-s/e?; reverse w/?
trimethroprim
dihydrofolate reductase
granulocytopenia, leukopenia, megaloblastic anemia; folinic acid
9
-1st line haem (otitis, sinusitis, pneumonia, chancroid), moraxella (same but not chancroid), enterobacter>>> think RTIS in ?
-Tx gastroenteritis (salmonella, shigella)
-DOC for ?
-OK in ???
SMX-TMP aka cotrimoxazole, PEDS
nocardiosis, PCP
CHILDREN
10
FQ will treat IC bc it accumulates in ? and ?
macrophages, PMNs
11
FQ resistance: (2)
altered target site
decreased accumulation
12
-Tx UTIs, prostatitis (E coli, enterobacter); FQ w/ most clinical apps;
primarily gram ned aerobes
-pseudomonas associated with ?
-also shigella, salmonella, campylobacter, vibrio
cipro
cystic fibrosis
13
best bioavailability, best FQ for chlamydia trachomatis urethritis?
ofloxacin
14
most commonly Rx'ed FQ?
G+ activity against? (4)
levo
staph a., s pneumo, strept pyo, MDRSP
15
FQ- Tx only bronchitis and pneum (aka RTIs)
gemifloxacin
16
G4 FQ advantage- active against?
Tx MDRSP, skin, RTIs?
Tx- eye drops ONLY in bad conj?
anaerobes
moxifloxacin- widest spectrum FQ
gatifloxacin
17
s/e FQ (4)
ruptured achilles tendon
prolonged QT
phototoxicity
nephrotoxicity
18
FQ CI in ? and ? bc of ?
pregnancy, under 18, articular cartilage erosion
19
urine a/b - turns urine brown?
CI in ?
active against E coli, staph saprophytic us
prevents recurrent ? from UTIs in females
nitrofurantoin
pregnancy
cystitis
20