Pharm2Sulf/FQ

Question 1

sulf:
SOA:
s/e: ?uria, hypersensitivity, ? in newborns, drug potentiation from ?

Answer 1

G+&-

crystal, kernicterus, albumin displacement

Question 2

aka pediazole; otitis media (H flu) in peds

Answer 2

erythro (ESP) & sulfasoxazole

Question 3

UTIs, RTIs, gastroenteritis, PCP***

Answer 3

sulfamethoxazole-trimethroprim

Question 4

toxoplasmosis; give w/

Answer 4

sulfadiazine & pyramethamine; folinic acid

Question 5

broken down to 5-aminosalicylate; Tx IBD?

Answer 5

sulfasalazine (PO or suppository)

Question 6

topical for eye and skin infx, acne

Answer 6

sulfacetamide

Question 7

Tx burns, prevent sepsis

Answer 7

silver sulfadiazine

Question 8

• much more potent than sulfa’s, analog of dihydrofolic acid; UTIs & bacterial prostatitis?
• inhibits ? (second step in FA sun
• s/e?; reverse w/?

Answer 8

trimethroprim
dihydrofolate reductase
granulocytopenia, leukopenia, megaloblastic anemia; folinic acid

Question 9

• 1st line haem (otitis, sinusitis, pneumonia, chancroid), moraxella (same but not chancroid), enterobacter»> think RTIS in ?
• Tx gastroenteritis (salmonella, shigella)
• DOC for ?
• OK in ???

Answer 9

SMX-TMP aka cotrimoxazole, PEDS
nocardiosis, PCP
CHILDREN

Question 10

FQ will treat IC bc it accumulates in ? and ?

Answer 10

macrophages, PMNs

Question 11

FQ resistance: (2)

Answer 11

altered target site

decreased accumulation

Question 12

-Tx UTIs, prostatitis (E coli, enterobacter); FQ w/ most clinical apps;
primarily gram ned aerobes
-pseudomonas associated with ?
-also shigella, salmonella, campylobacter, vibrio

Answer 12

cipro

cystic fibrosis

Question 13

best bioavailability, best FQ for chlamydia trachomatis urethritis?

Answer 13

ofloxacin

Question 14

most commonly Rx’ed FQ?

G+ activity against? (4)

Answer 14

levo

staph a., s pneumo, strept pyo, MDRSP

Question 15

FQ- Tx only bronchitis and pneum (aka RTIs)

Answer 15

gemifloxacin

Question 16

G4 FQ advantage- active against?
Tx MDRSP, skin, RTIs?
Tx- eye drops ONLY in bad conj?

Answer 16

anaerobes
moxifloxacin- widest spectrum FQ
gatifloxacin

Question 17

s/e FQ (4)

Answer 17

ruptured achilles tendon
prolonged QT
phototoxicity
nephrotoxicity

Question 18

FQ CI in ? and ? bc of ?

Answer 18

pregnancy, under 18, articular cartilage erosion

Question 19

urine a/b - turns urine brown?
CI in ?
active against E coli, staph saprophytic us
prevents recurrent ? from UTIs in females

Answer 19

nitrofurantoin
pregnancy
cystitis

Question 20

methenamine mandelate/hippurate:

• decomposed at acidic pH into ? and provides ? effect
• in combo w/?

Answer 20

formaldehyde
antiseptic
sulfonamide