Flashcards in Pituitary Disease Deck (42)
List the hormones secreted from the anterior pituitary
List the hormones secreted from the posterior pituitary
Production of which peripheral hormone is stimulated by ACTH?
Production of which peripheral hormone is stimulated by LH and FSH?
Production of which peripheral hormone is stimulated by TSH?
Production of which peripheral hormone is stimulated by GH?
If too much hormone is produced, what kind of test is done?
If too little hormone is produced, what kind of test is done?
Give examples of pituitary stimulation tests
Insulin stress test
Prolonged glucagon test
Water deprivation test
Synthetic ACTH injection
A pituitary tumour less than 1cm is called a macroadenoma. True/False?
What is the most common visual defect caused by pituitary adenoma?
Dopamine inhibits production of prolactin. True/False?
Which drug is a dopamine antagonist that can cause excess prolactin?
List the main physiological causes of elevated prolactin
Hypothyroidism causes elevated prolactin. True/False?
List some early clinical features of elevated prolactin
List some late clinical features of elevated prolactin
What is acromegaly?
Excess production of growth hormone
List clinical features of acromegaly
Thickened soft tissues
What is the main treatment for acromegaly?
Trans-sphenoidal surgery to excise tumour/pituitary
What dopamine agonist can be used if surgery for acromegaly fails?
Somatostatin analogues are useful for acromegaly. True/False?
What causes Cushing's syndrome?
What are the clinical effects of cortisol on protein in the body?
Protein loss, causing:
(proximal) Muscle waisting
Cushing's can cause frontal balding in women. True/False?
What is the effect of exogenous high-dose steroid (dexamethasone) on cortisol?
Lowers serum cortisol by inhibiting hypothalamic-pituitary-adrenal axis
What is the main screening test for Cushing's syndrome?
Low-dose (1mg) dexamethasone test overnight
Cortisol should be less than 50 nmol/L next morning
What is the definitive test for diagnosing Cushing's syndrome?
2 day 2mg/day dexamethasone test
Cortisol should be less than 50 nmol/L after last dose
What are the 3 origins of Cushing's?